光可逆的タンパク質ラベル化技術の開発

1-5. References (chapter 1)

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9. Karginov, A. V.; Zou, Y.; Shirvanyants, D.; Kota, P.; Dokholyan, N. V.; Young, D. D.; Hahn, K. M.; Deiters, A., Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP. J. Am. Chem. Soc. 2011, 133 (3), 420–423.

10. Miyamoto, T.; DeRose, R.; Suarez, A.; Ueno, T.; Chen, M.; Sun, T.-p.; Wolfgang, M. J.; Mukherjee, C.; Meyers, D. J.; Inoue, T., Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat. Chem. Biol. 2012, 8 (5), 465–470.

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12.Brown, K. A.; Zou, Y.; Shirvanyants, D.; Zhang, J.; Samanta, S.; Mantravadi, P. K.; Dokholyan, N. V.; Deiters, A., Light-cleavable rapamycin dimer as an optical trigger for protein dimerization. Chem. Commun. 2015, 51 (26), 5702–5705.

13. Zhang, H.; Aonbangkhen, C.; Tarasovetc, E. V.; Ballister, E. R.; Chenoweth, D. M.; Lampson, M. A., Optogenetic control of kinetochore function. Nat. Chem. Biol. 2017, 13 (10), 1096–1101.

14. Akera, T.; Chmátal, L.; Trimm, E.; Yang, K.; Aonbangkhen, C.; Chenoweth, D. M.; Janke, C.; Schultz, R. M.; Lampson, M. A., Spindle asymmetry drives non-Mendelian chromosome segregation. Science 2017, 358 (6363), 668–672.

15. Kawano, F.; Suzuki, H.; Furuya, A.; Sato, M., Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat. Commun. 2015, 6 (1), 6256.

16. Guntas, G.; Hallett, R. A.; Zimmerman, S. P.; Williams, T.; Yumerefendi, H.; Bear, J. E.; Kuhlman, B., Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. Proc. Natl. Acad. Sci. USA 2015, 112 (1), 112–117.

17. Kennedy, M. J.; Hughes, R. M.; Peteya, L. A.; Schwartz, J. W.; Ehlers, M. D.; Tucker, C. L., Rapid blue-light–mediated induction of protein interactions in living cells. Nat. Methods 2010, 7 (12), 973-975.

18. Levskaya, A.; Weiner, O. D.; Lim, W. A.; Voigt, C. A., Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 2009, 461 (7266), 997–1001.

19.Bugaj, L. J.; Sabnis, A. J.; Mitchell, A.; Garbarino, J. E.; Toettcher, J. E.; Bivona, T. G.; Lim, W. A., Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science 2018, 361 (6405), eaao3048.

20. Toettcher, Jared E.; Weiner, Orion D.; Lim, Wendell A., Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module. Cell 2013, 155 (6), 1422–1434.

21. Toettcher, J. E.; Gong, D.; Lim, W. A.; Weiner, O. D., Light-based feedback for controlling intracellular signaling dynamics. Nat. Methods 2011, 8 (10), 837–839.

22.Benedetti, L.; Marvin, J. S.; Falahati, H.; Guillén-Samander, A.; Looger, L. L.; De Camilli, P., Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. eLife 2020, 9, e63230.

23. Hoelzel, C. A.; Zhang, X., Visualizing and Manipulating Biological Processes by Using HaloTag and SNAP-Tag Technologies. ChemBioChem 2020, 21 (14), 1935–1946.

24. Miller, L. W.; Cai, Y.; Sheetz, M. P.; Cornish, V. W., In vivo protein labeling with trimethoprim conjugates: a flexible chemical tag. Nat. Methods 2005, 2 (4), 255–257.

25. Los, G. V.; Encell, L. P.; McDougall, M. G.; Hartzell, D. D.; Karassina, N.; Zimprich, C.; Wood, M. G.; Learish, R.; Ohana, R. F.; Urh, M.; Simpson, D.; Mendez, J.; Zimmerman, K.; Otto, P.; Vidugiris, G.; Zhu, J.; Darzins, A.; Klaubert, D. H.; Bulleit, R. F.; Wood, K. V., HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis. ACS Chem. Biol. 2008, 3 (6), 373–382.

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27. Voß, S.; Klewer, L.; Wu, Y.-W., Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells. Curr. Opin. Chem. Biol. 2015, 28, 194–201.

28. Kowada, T.; Arai, K.; Yoshimura, A.; Matsui, T.; Kikuchi, K.; Mizukami, S., Optical Manipulation of Subcellular Protein Translocation Using a Photoactivatable Covalent Labeling System. Angew. Chem. Int. Ed. 2021, 60 (20), 11378–11383.

29.Chen, X.; Venkatachalapathy, M.; Kamps, D.; Weigel, S.; Kumar, R.; Orlich, M.; Garrecht, R.; Hirtz, M.; Niemeyer, C. M.; Wu, Y.-W.; Dehmelt, L., “Molecular Activity Painting”: Switch-like, LightControlled Perturbations inside Living Cells. Angew. Chem. Int. Ed. 2017, 56 (21), 5916–5920.

30. Zimmermann, M.; Cal, R.; Janett, E.; Hoffmann, V.; Bochet, C. G.; Constable, E.; Beaufils, F.; Wymann, M. P., Cell-Permeant and Photocleavable Chemical Inducer of Dimerization. Angew. Chem. Int. Ed. 2014, 53 (18), 4717–4720.

31.Ballister, E. R.; Aonbangkhen, C.; Mayo, A. M.; Lampson, M. A.; Chenoweth, D. M., Localized lightinduced protein dimerization in living cells using a photocaged dimerizer. Nat. Commun. 2014, 5 (1), 5475.

32. Aonbangkhen, C.; Zhang, H.; Wu, D. Z.; Lampson, M. A.; Chenoweth, D. M., Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer. J. Am. Chem. Soc. 2018, 140 (38), 11926–11930.

33.Chen, X.; Wu, Y.-W., Tunable and Photoswitchable Chemically Induced Dimerization for Chemooptogenetic Control of Protein and Organelle Positioning. Angew. Chem. Int. Ed. 2018, 57 (23), 6796– 6799.

2-7. References (chapter 2)

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26. Aonbangkhen, C.; Zhang, H.; Wu, D. Z.; Lampson, M. A.; Chenoweth, D. M., Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer. J. Am. Chem. Soc. 2018, 140 (38), 11926–11930.

27. Zhang, H.; Aonbangkhen, C.; Tarasovetc, E. V.; Ballister, E. R.; Chenoweth, D. M.; Lampson, M. A., Optogenetic control of kinetochore function. Nat. Chem. Biol. 2017, 13 (10), 1096–1101.

28.Ballister, E. R.; Aonbangkhen, C.; Mayo, A. M.; Lampson, M. A.; Chenoweth, D. M., Localized lightinduced protein dimerization in living cells using a photocaged dimerizer. Nat. Commun. 2014, 5 (1), 5475.

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3-8. References (chapter 3)

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2. Lavoie, H.; Therrien, M., Regulation of RAF protein kinases in ERK signalling. Nat. Rev. Mol. Cell Biol. 2015, 16 (5), 281–298.

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7. Guntas, G.; Hallett, R. A.; Zimmerman, S. P.; Williams, T.; Yumerefendi, H.; Bear, J. E.; Kuhlman, B., Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. Proc. Natl. Acad. Sci. USA 2015, 112 (1), 112–117.

8. Kennedy, M. J.; Hughes, R. M.; Peteya, L. A.; Schwartz, J. W.; Ehlers, M. D.; Tucker, C. L., Rapid blue-light–mediated induction of protein interactions in living cells. Nat. Methods 2010, 7 (12), 973–975.

9. Levskaya, A.; Weiner, O. D.; Lim, W. A.; Voigt, C. A., Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 2009, 461 (7266), 997–1001.

10. Farahani, P. E.; Reed, E. H.; Underhill, E. J.; Aoki, K.; Toettcher, J. E., Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems. Annu. Rev. Biomed. Eng. 2021, 23 (1), 61–87.

11. Ma, G.; He, L.; Liu, S.; Xie, J.; Huang, Z.; Jing, J.; Lee, Y.-T.; Wang, R.; Luo, H.; Han, W.; Huang, Y.; Zhou, Y., Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nat. Commun. 2020, 11 (1), 1039.

12.Bugaj, L. J.; Sabnis, A. J.; Mitchell, A.; Garbarino, J. E.; Toettcher, J. E.; Bivona, T. G.; Lim, W. A., Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science 2018, 361 (6405), eaao3048.

13. Toettcher, Jared E.; Weiner, Orion D.; Lim, Wendell A., Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module. Cell 2013, 155 (6), 1422–1434.

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20. Voß, S.; Klewer, L.; Wu, Y.-W., Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells. Curr. Opin. Chem. Biol. 2015, 28, 194–201.

21.Brown, K. A.; Zou, Y.; Shirvanyants, D.; Zhang, J.; Samanta, S.; Mantravadi, P. K.; Dokholyan, N. V.; Deiters, A., Light-cleavable rapamycin dimer as an optical trigger for protein dimerization. Chem. Commun. 2015, 51 (26), 5702–5705.

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23. Kowada, T.; Arai, K.; Yoshimura, A.; Matsui, T.; Kikuchi, K.; Mizukami, S., Optical Manipulation of Subcellular Protein Translocation Using a Photoactivatable Covalent Labeling System. Angew. Chem. Int. Ed. 2021, 60 (20), 11378–11383.

24. Zimmermann, M.; Cal, R.; Janett, E.; Hoffmann, V.; Bochet, C. G.; Constable, E.; Beaufils, F.; Wymann, M. P., Cell-Permeant and Photocleavable Chemical Inducer of Dimerization. Angew. Chem. Int. Ed. 2014, 53 (18), 4717–4720.

25.Ballister, E. R.; Aonbangkhen, C.; Mayo, A. M.; Lampson, M. A.; Chenoweth, D. M., Localized lightinduced protein dimerization in living cells using a photocaged dimerizer. Nat. Commun. 2014, 5 (1), 5475.

26.Chen, X.; Wu, Y.-W., Tunable and Photoswitchable Chemically Induced Dimerization for Chemooptogenetic Control of Protein and Organelle Positioning. Angew. Chem. Int. Ed. 2018, 57 (23), 6796– 6799.

27. Aonbangkhen, C.; Zhang, H.; Wu, D. Z.; Lampson, M. A.; Chenoweth, D. M., Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer. J. Am. Chem. Soc. 2018, 140 (38), 11926–11930.

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29. Akera, T.; Chmátal, L.; Trimm, E.; Yang, K.; Aonbangkhen, C.; Chenoweth, D. M.; Janke, C.; Schultz, R. M.; Lampson, M. A., Spindle asymmetry drives non-Mendelian chromosome segregation. Science 2017, 358 (6363), 668–672.

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