The Biology of Cryptosporidium Infection

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The Biology of Cryptosporidium Infection
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STRIEPEN Boris
Journal of Integrated Field Science
17
28-29
2020-03
http://hdl.handle.net/10097/00128795

Oral Session

28

Keynote Lecture

S-1.

The Biology of Cryptosporidium Infection
Boris STRIEPEN
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania

The protozoan parasite Cryptosporidium is a leading cause of severe diarrhea in young children and an important contributor to
early childhood mortality. Effective drugs and vaccines are lacking, in part due to the overall poor tractability of this parasite. To
overcome this, we established molecular genetics for Cryptosporidium and a natural mouse model of infection. This seminar will
focus on recent and largely unpublished work to understand the cell biology of Cryptosporidium infection. First, I will discuss how
the parasite manipulates the host cell by injecting proteins using two independent delivery systems. Then I will describe what we
are learning about the parasite’s lifecycle. The entire cycle, including an asexual and a sexual phase unfolds over three days and is
tractable in culture and in animals for a significant portion. This is a remarkably simple model that can be interrogated by live cell
imaging, single cell sequencing and genetic manipulation. ...

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