リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Stromal reaction inhibitor and immune-checkpoint inhibitor combination therapy attenuates excluded-type colorectal cancer in a mouse model」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Stromal reaction inhibitor and immune-checkpoint inhibitor combination therapy attenuates excluded-type colorectal cancer in a mouse model

頼田 尚樹 広島大学

2021.03.23

概要

The discovery of immune-checkpoint inhibitors (ICIs), including the
anti-programmed cell death-1 (PD-1) antibody, dramatically advanced
immunotherapy in clinical practice [1–4]. However, the benefits of
cancer immunotherapy for colon cancer have only been observed in
cases with microsatellite instability (MSI) [5,6]. Although there have
been attempts to improve treatment efficacy through the concomitant
administration of immunotherapy and other drugs [7,8], no highly
efficacious combinations for CRC treatment have been discovered.
Tumor tissue consists of cancer cells and various stromal cells,
including immune cells [9–11]. ...

この論文で使われている画像

参考文献

[1] J.S. Weber, S.P. D’Angelo, D. Minor, F.S. Hodi, R. Gutzmer, B. Neyns, C. Hoeller, N.

I. Khushalani, W.H. Miller, C.D. Lao, G.P. Linette, L. Thomas, P. Lorigan, K.

F. Grossmann, J.C. Hassel, M. Maio, M. Sznol, P.A. Ascierto, P. Mohr,

B. Chmielowski, A. Bryce, I.M. Svane, J.-J. Grob, A.M. Krackhardt, C. Horak,

A. Lambert, A.S. Yang, J. Larkin, Nivolumab versus chemotherapy in patients with

advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate

037): a randomised, controlled, open-label, phase 3 trial, Lancet Oncol. 16 (2015)

375–384.

[2] E.B. Garon, N.A. Rizvi, R. Hui, N. Leighl, A.S. Balmanoukian, J.P. Eder, A. Patnaik,

C. Aggarwal, M. Gubens, L. Horn, E. Carcereny, M.-J. Ahn, E. Felip, J.-S. Lee, M.

D. Hellmann, O. Hamid, J.W. Goldman, J.-C. Soria, M. Dolled-Filhart, R.

Z. Rutledge, J. Zhang, J.K. Lunceford, R. Rangwala, G.M. Lubiniecki, C. Roach,

K. Emancipator, Gandhi L for the KEYNOTE-001 Investigators. Pembrolizumab for

the treatment of non–small-cell lung cancer, N. Engl. J. Med. 372 (2015)

2018–2028.

[3] H. Borghaei, L. Paz-Ares, L. Horn, D.R. Spigel, M. Steins, N.E. Ready, L.Q. Chow, E.

E. Vokes, E. Felip, E. Holgado, F. Barlesi, M. Kohlhaufl, O. Arrietta, M.A. Burgio,

FayetteJ, H. Lena, E. Poddubskaya, D.E. Gerber, S.N. Gettinger, C.M. Rudin,

N. Rizvi, L. Crino, G.R. Blumenschein Jr., S.J. Antonia, C. Dorange, C.T. Harbison,

F.G. Finckenstein, J.R. Brahmer, Nivolumab versus docetaxel in advanced

nonsquamous non–small-cell lung cancer, N. Engl. J. Med. 373 (2015) 1627–1639.

[4] J. Brahmer, K.L. Reckamp, P. Baas, L. Crino, W.E.E. Eberhardt, E. Poddubskaya,

S. Antonia, A. Pluzanski, E.E. Vokes, E. Holgado, D. Waterhouse, N. Ready,

119

N. Yorita et al.

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

Cancer Letters 498 (2021) 111–120

J. Gainor, O.A. Frontera, L. Havel, M. Steins, M.C. Garassino, J.G. Aerts,

M. Domine, L. Paz-Ares, M. Reck, C. Baudelet, C.T. Harbison, B. Lestini, D.

R. Spigel, Nivolumab versus docetaxel in advanced squamous-cell non–small-cell

lung cancer, N. Engl. J. Med. 3 73 (2015) 123–135.

Cancer Genome Atlas Network, Comprehensive molecular characterization of

human colon and rectal cancer, Nature 487 (2012) 330–337.

R. Gryfe, H. Kim, E.T.K. Hsieh, M.D. Aronson, E.J. Holowaty, S.B. Bull, M. Redston,

S. Gallinger, Tumor microsatellite instability and clinical outcome in young

patients with colorectal cancer, N. Engl. J. Med. 342 (2000) 69–77.

L. Gandhi, D. Rodríguez-Abreu, S. Gadgeel, E. Esteban, E. Felip, F. De Angelis,

M. Domine, P. Clingan, M.J. Hochmair, S.F. Powell, S.Y. Cheng, H.G. Bischoff,

N. Peled, F. Grossi, R.R. Jennens, M. Reck, R. Hui, E.B. Garon, M. Boyer, B. RubioViqueira, S. Novello, T. Kurata, J.E. Gray, J. Vida, Z. Wei, J. Yang, H. Raftopoulos,

M.C. Pietanza, M.C. Garassino, KEYNOTE-189 investigators. Pembrolizumab plus

chemotherapy in metastatic non-small-cell lung cancer, N. Engl. J. Med. 378

(2018) 2078–2092.

C.J. Langer, S.M. Gadgeel, H. Borghaei, V.A. Papadimitrakopoulou, A. Patnaik, S.

F. Powell, R.D. Gentzler, R.G. Martins, J.P. Stevenson, S.I. Jalal, A. Panwalkar, J.

C. Yang, M. Gubens, L.V. Sequist, M.M. Awad, J. Fiore, Y. Ge, H. Raftopoulos,

L. Gandhi, KEYNOTE-021 investigators. Carboplatin and pemetrexed with or

without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a

randomised, phase 2 cohort of the open-label KEYNOTE-021 study, Lancet Oncol.

17 (2016) 1497–1508.

G. Bindea, B. Mlecnik, M. Tosolini, A. Kirilovsky, M. Waldner, A.C. Obenauf,

H. Angell, T. Fredriksen, L. Lafontaine, A. Berger, P. Bruneval, W.H. Fridman,

C. Becker, F. Pages, M.R. Speicher, Z. Trajanoski, J. Galon, Spatiotemporal

dynamics of intratumoral immune cells reveal the immune landscape in human

cancer, Immunity 39 (2013) 782–795.

J. Galon, A. Costes, F. Sanchez-Cabo, A. Kirilovsky, B. Mlecnik, C. Lagorce-Pages,

M. Tosolini, M. Camus, A. Berger, P. Wind, F. Zinzindohoue, P. Bruneval, P.H. Cugnenc, Z. Trajanoski, W.-H. Fridman, F. Pages, Type, density, and location of

immune cells within human colorectal tumors predict clinical outcome, Science

313 (2006) 1960–1964.

F. Pag`es, A. Berger, M. Camus, F. Sanchez-Cabo, A. Costes, R. Molidor, B. Mlecnik,

A. Kirilovsky, M. Nilsson, D. Damotte, T. Meatchi, P. Bruneval, P.-H. Cugnenc,

Z. Trajanoski, W.-H. Fridman, J. Galon, Effector memory T cells, early metastasis,

and survival in colorectal cancer, N. Engl. J. Med. 353 (2005) 2654–2666.

L. Ziani, S. Chouaib, J. Thiery, Alteration of the antitumor immune response by

cancer-associated fibroblasts, Front. Immunol. 9 (2018) 414.

A. Orimo, P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, R. Naeem, V.

J. Carey, A.L. Richardson, R.A. Weinberg, Stromal fibroblasts present in invasive

human breast carcinomas promote tumor growth and angiogenesis through

elevated SDF-1/CXCL12 secretion, Cell 121 (2005) 335–348.

Y. Kitadai, T. Sasaki, T. Kuwai, T. Nakamura, C.D. Bucana, S.R. Hamilton, I.

J. Fidler, Expression of activated platelet-derived growth factor receptor in stromal

cells of human colon carcinomas is associated with metastatic potential, Int. J.

Canc. 119 (2006) 2567–2574.

Olivier De Wever, M. Mareel, Role of tissue stroma in cancer cell invasion,

J. Pathol. 200 (2003) 429–447.

R. Yuge, Y. Kitadai, K. Shinagawa, M. Onoyama, S. Tanaka, W. Yasui, K. Chayama,

mTOR and PDGF pathway blockade inhibits liver metastasis of colorectal cancer by

modulating the tumor microenvironment, Am. J. Pathol. 185 (2015) 399–408.

H. Takigawa, Y. Kitadai, K. Shinagawa, R. Yuge, Y. Higashi, S. Tanaka, W. Yasui,

K. Chayama, Multikinase inhibitor regorafenib inhibits the growth and metastasis

of colon cancer with abundant stroma, Canc. Sci. 107 (2016) 601–608.

R. Yuge, Y. Kitadai, H. Takigawa, T. Naito, N. Oue, W. Yasui, S. Tanaka,

K. Chayama, Silencing of discoidin domain receptor-1 (DDR1) concurrently

inhibits multiple steps of metastasis cascade in gastric cancer, Transl Oncol 11

(2018) 575–584.

T.F. Gajewski, The next hurdle in cancer immunotherapy: overcoming the non–Tcell-inflamed tumor microenvironment, Semin. Oncol. 42 (2015) 663–671.

P.S. Hegde, V. Karanikas, S. Evers, The where, the when, and the how of immune

monitoring for cancer immunotherapies in the era of checkpoint inhibition, Clin.

Canc. Res. 22 (2016) 1865–1874.

F. Pages, B. Mlecnik, F. Marliot, G. Bindea, F.S. Ou, C. Bifulco, A. Lugli, I. Zlobec, T.

T. Rau, M.D. Berger, I.D. Nagtegaal, E. Vink-B¨

orger, A. Hartmann, C. Geppert,

J. Kolwelter, S. Merkel, R. Grützmann, M. Van den Eynde, A. Jouret-Mourin,

A. Kartheuser, D. L´eonard, C. Remue, J.Y. Wang, P. Bavi, M.H.A. Roehrl, P.

S. Ohashi, L.T. Nguyen, S. Han, H.L. MacGregor, S. Hafezi-Bakhtiari, B.G. Wouters,

G.V. Masucci, E.K. Andersson, E. Zavadova, M. Vocka, J. Spacek, L. Petruzelka,

B. Konopasek, P. Dundr, H. Skalova, K. Nemejcova, G. Botti, F. Tatangelo, P. Delrio,

G. Ciliberto, M. Maio, L. Laghi, F. Grizzi, T. Fredriksen, B. Buttard, M. Angelova,

A. Vasaturo, P. Maby, S.E. Church, H.K. Angell, L. Lafontaine, D. Bruni, C. El Sissy,

N. Haicheur, A. Kirilovsky, A. Berger, C. Lagorce, J.P. Meyers, C. Paustian, Z. Feng,

C. Ballesteros-Merino, J. Dijkstra, C. van de Water, S. van Lent-van Vliet, N. Knijn,

A. Mușin˘

a, D. Scripcariu, B. Popivanova, M. Xu, T. Fujita, S. Hazama, N. Suzuki,

H. Nagano, K. Okuno, T. Torigoe, N. Sato, T. Furuhata, I. Takemasa, K. Itoh, P.

S. Patel, H.H. Vora, B. Shah, J.B. Patel, K.N. Rajvik, S.J. Pandya, S.N. Shukla,

Y. Wang, G. Zhang, Y. Kawakami, F.M. Marincola, P.A. Ascierto, D.J. Sargent, B.

A. Fox, J. Galon, International validation of the consensus Immunoscore for the

classification of colon cancer: a prognostic and accuracy study, Lancet 391 (2018)

2128–2139.

[22] E. Lanitis, M. Irving, G. Coukos, Targeting the tumor vasculature to enhance T cell

activity, Curr. Opin. Immunol. 33 (2015) 55–63.

[23] L.Y. Tan, C. Martini, Z.G. Fridlender, C.S. Bonder, M.P. Brown, L.M. Ebert, Control

of immune cell entry through the tumour vasculature: a missing link in optimising

melanoma immunotherapy? Clin Transl Immunol 6 (2017) e134.

[24] N. Nagarsheth, M.S. Wicha, W. Zou, Chemokines in the cancer microenvironment

and their relevance in cancer immunotherapy, Nat. Rev. Immunol. 17 (2017)

559–572.

[25] M. Camus, M. Tosolini, B. Mlecnik, F. Pages, A. Kirilovsky, A. Berger, A. Costes,

G. Bindea, P. Charoentong, P. Bruneval, Z. Trajanoski, W.-H. Fridman, J. Galon,

Coordination of intratumoral immune reaction and human colorectal cancer

recurrence, Canc. Res. 69 (2009) 2685–2693.

[26] H. Tang, Y. Wang, L.K. Chlewicki, Y. Zhang, J. Guo, W. Liang, J. Wang, X. Wang,

Y.-X. Fu, Facilitating T cell infiltration in tumor microenvironment overcomes

resistance to PD-L1 blockade, Canc. Cell 29 (2016) 285–296.

[27] T. Sumida, Y. Kitadai, K. Shinagawa, M. Tanaka, M. Kodama, M. Ohnishi, E. Ohara,

S. Tanaka, W. Yasui, K. Chayama, Anti-stromal therapy with imatinib inhibits

growth and metastasis of gastric carcinoma in an orthotopic nude mouse model,

Int. J. Canc. 128 (2011) 2050–2062.

[28] E. Vilar, S.B. Gruber, Microsatellite instability in colorectal cancer–the stable

evidence, Nat. Rev. Clin. Oncol. 7 (2010) 153–162.

[29] N.M. Lindor, L.J. Burgart, O. Leontovich, R.M. Goldberg, J.M. Cunningham, D.

J. Sargent, C. Walsh-Vockley, G.M. Petersen, M.D. Walsh, B.A. Leggett, J.P. Young,

M.A. Barker, J.R. Jass, J. Hopper, S. Gallinger, B. Bapat, M. Redston, S.

N. Thibodeau, Immunohistochemistry versus microsatellite instability testing in

phenotyping colorectal tumors, J. Clin. Oncol. 20 (2002) 1043–1048.

[30] T.C. Smyrk, P. Watson, K. Kaul, H.T. Lynch, Tumor-infiltrating lymphocytes are a

marker for microsatellite instability in colorectal carcinoma, Cancer 91 (2001)

2417–2422.

[31] Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 15545–15550.

[32] P.C. Tumeh, C.L. Harview, J.H. Yearly, I.P. Shintaku, E.J.M. Taylor, L. Robert,

B. Chmielowski, M. Spasic, G. Henry, V. Ciobanu, A.N. West, M. Carmona,

C. Kivork, E. Seja, G. Cherry, A.J. Gutierrez, T.R. Grogan, C. Mateus, G. Tomasic, J.

A. Glaspy, R.O. Emerson, H. Robins, R.H. Pierce, D.A. Elashoff, C. Robert, A. Ribas,

PD-1 blockade induces responses by inhibiting adaptive immune resistance, Nature

515 (2014) 568–571.

[33] S. Spranger, R. Bao, T.F. Gajewski, Melanoma- intrinsic beta-catenin signalling

prevents anti-tumour immunity, Nature 523 (2015) 231–235.

[34] T. Iwata-Kajihara, H. Sumimoto, N. Kawamura, R. Ueda, T. Takahashi,

H. Mizuguchi, M. Miyagishi, K. Takeda, Y. Kawakami, Enhanced cancer

immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing

ability and resistance to cancer cell-derived inhibitory factors, J. Immunol. 187

(2011) 27–36.

[35] B. Mlecnik, G. Bindea, H.K. Angell, P. Maby, M. Angelova, D. Tougeron, S.

E. Church, L. Lafontaine, M. Fischer, T. Fredriksen, M. Sasso, A.M. Bilocq,

A. Kirilovsky, A.C. Obenauf, M. Hamieh, A. Berger, P. Bruneval, J.-J. Tuech, J.C. Sabourin, F. Le Pessot, J. Mauillon, A. Rafii, P. Laurent-Puig, M.R. Speicher,

Z. Trajanoski, P. Michel, R. Sesboue, T. Frebourg, F. Pages, V. Valge-Archer, J.B. Latouche, J. Galon, Integrative analyses of colorectal cancer show immunoscore

is a stronger predictor of patient survival than microsatellite instability, Immunity

44 (2016) 698–711.

[36] D.S. Williams, M.J. Bird, R.N. Jorissen, Y.L. Yu, F. Walker, H.H. Zhang, E.C. Nice,

BurgessAW, Nonsense mediated decay resistant mutations are a source of

expressed mutant proteins in colon cancer cell lines with microsatellite instability,

PloS One 5 (2010), e16012.

[37] D.T. Le, J.N. Uram, H. Wang, B. Bartlett, H. Kemberling, A. Eyring, N.S. Azad,

D. Laheru, R.C. Donehower, T.S. Crocenzi, R.M. Goldberg, G.A. Fisher, J.J. Lee, T.

F. Greten, M. Koshiji, S.P. Kang, R.A. Anders, J.R. Eshleman, B. Vogelstein, L.

A. Diaz, Programmed death-1 blockade in mismatch repair deficient colorectal

cancer, J. Clin. Oncol. 34 (15_suppl) (2016) 103.

[38] J. Paulsson, T. Sj¨

oblom, P. Micke, F. Ponten, G. Landberg, C.-H. Heldin, J. Bergh, D.

J. Brennan, K. Jirstrom, A. Ostman, Prognostic significance of stromal plateletderived growth factor beta-receptor expression in human breast cancer, Am. J.

Pathol. 175 (2009) 334–341.

[39] G. Lindmark, C. Sundberg, B. Glimelius, L. Pahlman, K. Rubin, B. Gerdin, Stromal

expression of platelet-derived growth factor beta-receptor and platelet-derived

growth factor B-chain in colorectal cancer, Lab. Invest. 69 (1993) 682–689.

[40] H.N. Antoniades, T. Galanopoulos, J. Neville-Golden, C.J. O’Hara, Malignant

epithelial cells in primary human lung carcinomas coexpress in vivo plateletderived growth factor (PDGF) and PDGF receptor mRNAs and their protein

products, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3942–3946.

[41] M. Onoyama, Y. Kitadai, Y. Tanaka, R. Yuge, K. Shinagawa, S. Tanaka, W. Yasui,

K. Chayama, Combining molecular targeted drugs to inhibit both cancer cells and

activated stromal cells in gastric cancer, Neoplasia 15 (2013) 1391–1399.

[42] K. Pietras, A. Ostman,

M. Sj¨

oquist, E. Buchdunger, R.K. Reed, C.-H. Heldin,

K. Rubin, Inhibition of platelet-derived growth factor receptors reduces interstitial

hypertension and increases transcapillary transport in tumors, Canc. Res. 61

(2001) 2929–2934.

[43] K. Pietras, Increasing tumor uptake of anticancer drugs with imatinib, Semin.

Oncol. 31 (2004) 18–23.

120

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る