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Salman et al .
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Supplemental Fig. 1. Sensitivity analysis of adjusted odds ratio for the presence of MRI outcomes per 1-SD higher office BP
indexes in Visits 1 [V1 = 443] (aged 40–80) and 2 [V2 = 390] (aged 46–83) after the exclusion of participants
receiving hypertension medication
The variables adjusted in the multivariable model in Visits 1 and 2 are age, BMI, HbA1c, LDL-C, HDL-C, smoking status, drinking status,
diabetes mellitus medication, and dyslipidemia medication. V1, Visit 1; V2, Visit 2; OR, odds ratio; SBP, systolic blood pressure; DBP,
diastolic blood pressure; PP, pulse pressure; MAP, mean arterial pressure
12
Advance Publication Journal of Atherosclerosis and Thrombosis
Accepted for publication: November 9, 2020 Published online: January 22, 2021
BP Indexes and Cerebrovascular Disease
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Supplemental Fig. 2. Multivariable adjusted odds ratio for the presence of MRI outcomes per 1-SD higher home BP indexes of
616 men in Visits 1 (aged 40–80) and 2 (aged 46–83)
The variables adjusted in the multivariable model in Visits 1 and 2 are age, BMI, HbA1c, LDL-C, HDL-C, smoking status, drinking status,
hypertension medication, diabetes mellitus medication, and dyslipidemia medication. V1, Visit 1; V2, Visit 2; OR, odds ratio; SBP, systolic
blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; MAP, mean arterial pressure
Advance Publication Journal of Atherosclerosis and Thrombosis
Accepted for publication: November 9, 2020 Published online: January 22, 2021
13
Salman et al .
Supplemental Table 1. Frequency of participants in each score value of
the total small vessel disease score (N = 616)
SVD Score
n (%)
346 (56.2)
137 (22.3)
76 (12.3)
42 (6.8)
15 (2.4)
Values are presented as number (percentage)
SVD, small vessel disease
Supplemental Table 2. Univariable and multivariable ordinal logistic regression for the relationship of 1-SD
office BP indexes and total small vessel disease score (N = 616)
Total SVD score
SBP
V1
V2
DBP
V1
V2
PP
V1
V2
MAP
V1
V2
OR (95% CI)
P value
OR (95% CI)
P value
OR (95% CI)
P value
OR (95% CI)
P value
OR (95% CI)
P value
OR (95% CI)
P value
OR (95% CI)
P value
OR (95% CI)
P value
Univariable model
Multivariable model
1.52 (1.30 - 1.78)
＜ 0.001
1.44 (1.23 - 1.67)
＜ 0.001
1.32 (1.14 - 1.54)
0.001
1.11 (0.95 - 1.29)
0.177
1.42 (1.22 - 1.65)
＜ 0.001
1.48 (1.27 - 1.72)
＜ 0.001
1.45 (1.24 - 1.69)
＜ 0.001
1.27 (1.09 - 1.48)
0.002
1.34 (1.13 - 1.57)
0.001
1.33 (1.13 - 1.56)
0.001
1.41 (1.19 - 1.66)
＜ 0.001
1.34 (1.13 - 1.58)
0.001
1.14 (0.96 - 1.35)
0.142
1.20 (1.01 - 1.42)
0.038
1.40 (1.19 - 1.65)
＜ 0.001
1.36 (1.16 - 1.60)
0.001
The variables adjusted in the multivariable model in Visit 1 and Visit 2 are age, BMI, HbA1c, LDL-C, HDL-C, smoking status,
drinking status, hypertension medication, diabetes mellitus medication, and dyslipidemia medication.
SVD, small vessel disease; V1, Visit 1; V2, Visit 2; OR, odds ratio; SBP, systolic blood pressure; DBP, diastolic blood
pressure; PP, pulse pressure; MAP, mean arterial pressure
14
Advance Publication Journal of Atherosclerosis and Thrombosis
Accepted for publication: November 9, 2020 Published online: January 22, 2021
...
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