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大学・研究所にある論文を検索できる 「The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study.」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study.

KHAN Md Maruf Haque FUJIYOSHI Akira 10567077 0000-0002-5790-7119 SHIINO Akihiko 50215935 0000-0001-6203-9339 HISAMATSU Takashi TORII Sayuki 30773973 SUZUKI Sentaro KUNIMURA Ayako SEGAWA Hiroyoshi 0000-0001-9631-9769 KADOTA Aya 60546068 0000-0001-7378-0544 OHKUBO Takayoshi 60344652 0000-0002-3283-8196 NOZAKI Kazuhiko 90252452 0000-0003-1623-068X MIURA Katsuyuki 90257452 0000-0002-2646-9582 UESHIMA Hirotsugu 70144483 0000-0002-7742-4253 滋賀医科大学

2020.09.01

概要

Aim:
Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. However, few studies have described the association between CAC and SCVDs. Therefore, the aim of this study was to assess the clinical relationship between CAC and SCVDs in a healthy Japanese male population.
Methods:
In this observational study, 709 men, free of stroke, were sampled from a city in Japan from 2010 to 2014. CAC was scored using the Agatston method. The following SCVDs were assessed using magnetic resonance imaging: intracranial arterial stenosis (ICAS), lacunar infarction, deep and subcortical white matter hyperintensity (DSWMH), periventricular hyperintensity (PVH), and microbleeds. The participants were categorized according to CAC scores as follows: no CAC (0), mild CAC (1-100), and moderate-to-severe CAC (>100). The adjusted odds ratios of prevalent SCVDs were computed in reference to the no-CAC group using logistic regression.
Results:
The mean (standard deviation) age of the participants was 68 (8.4) years. Participants in the moderate-to-severe CAC category showed significantly higher odds of prevalent lacunar infarction, DSWMH, and ICAS in age-adjusted and risk-factor-adjusted models. Microbleeds and PVH, in contrast, did not show any significant associations. The trends for CAC with lacunar infarction, DSWMH, and ICAS were also significant (all P-values for trend ≤ 0.02).
Conclusions:
Higher CAC scores were associated with higher odds of lacunar infarction, DSWMH, and ICAS. The presence and degree of CAC may be a useful indicator for SCVDs involving small and large vessels.

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参考文献

1) Osawa K, Nakanishi R, and Budoff M: Coronary artery calcification. Glob Heart, 2016; 11: 287-293

2) Vliegenthart R, Hollander M, Breteler MM, van der Kuip DA, Hofman A, Oudkerk M, and Witteman JC: Stroke is associated with coronary calcification as detected by electron-beam CT: the Rotterdam Coronary Calcification Study. Stroke, 2002; 33: 462-465

3) Fujiyoshi A, Jacobs DR, Fitzpatrick AL, Alonso A, Duprez DA, Sharrett AR, Seeman T, Blaha MJ, Luchsinger JA, Rapp SR: Coronary Artery Calcium and Risk of Dementia in MESA (Multi-Ethnic Study of Atherosclerosis). Circ Cardiovasc Imaging, 2017; 10: e005349

4) Pantoni L: Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol, 2010; 9: 689-701

5) Oh HG, Chung PW, and Rhee EJ: Increased risk for intracranial arterial stenosis in subjects with coronary artery calcification. Stroke, 2015; 46: 151-156

6) Vidal JS, Sigurdsson S, Jonsdottir MK, Eiriksdottir G, Thorgeirsson G, Kjartansson O, Garcia ME, van Buchem MA, Harris TB, Gudnason V, and Launer LJ: Coronary artery calcium, brain function and structure: the AGESReykjavik Study. Stroke, 2010; 41: 891-897

7) Bos D, Ikram MA, Elias-Smale SE, Krestin GP, Hofman A, Witteman JC, van der Lugt A, and Vernooij MW: Calcification in major vessel beds relates to vascular brain disease. Arterioscler Thromb Vasc Biol, 2011; 31: 2331- 2337

8) de Weert TT, Cakir H, Rozie S, Cretier S, Meijering E, Dippel DW, and van der Lugt A: Intracranial internal carotid artery calcifications: association with vascular risk factors and ischemic cerebrovascular disease. Am J Neuroradiol, 2009; 30: 177-184

9) Shitara S, Fujiyoshi A, Hisamatsu T, Torii S, Suzuki S, Ito T, Arima H, Shiino A, Nozaki K, Miura K, and Ueshima H: Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men. Stroke, 2019; 50: 2967-2969

10) Nomura Y, Faegle R, Hori D, Al-Qamari A, Nemeth AJ, Gottesman R, Yenokyan G, Brown C, and Hogue CW: Cerebral small vessel, but not large vessel disease, is associated with impaired cerebral autoregulation during cardiopulmonary bypass: a retrospective cohort study. Anesth Analg, 2018; 127: 1314-1322

11) Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, and Kita T: Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population. Atherosclerosis, 2016; 246: 141-147

12) Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, and Detrano R: Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol, 1990; 15: 827-832

13) Shinohara Y, Tohgi H, Hirai S, Terashi A, Fukuuchi Y, Yamaguchi T, and Okudera T: Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). Cerebrovasc Dis, 2007; 24: 202-209

14) A new guideline making committee of a brain dock. Brain MRI examination In: Japanese Society for Detection of Asymptomatic Brain Disease, ed. Braindock Guideline 2014 [in Japanese]. 4th ed. Tokyo, Japan: Kyobunsha; 2014: 38-47

15) Fazekas F, Chawluk JB, Alavi A, Hurtig HI, and Zimmerman RA: MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. Am J Roentgenol, 1987; 149: 351-356

16) Samuels OB, Joseph GJ, Lynn MJ, Smith HA, and Chimowitz MI: A standardized method for measuring intracranial arterial stenosis. Am J Neuroradiol, 2000; 21: 643- 646

17) Nakamura M, Sato S, and Shimamoto T: Improvement in Japanese clinical laboratory measurements of total cholesterol and HDL-cholesterol by the US Cholesterol Reference Method Laboratory Network. J Atheroscler Thromb, 2003; 10: 145-153

18) Friedewald WT, Levy RI, and Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem, 1972; 18: 499-502

19) Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, Ito H, Tominaga M, Oikawa S, Noda M, Kawamura T, Sanke T, Namba M, Hashiramoto M, Sasahara T, Nishio Y, Kuwa K, Ueki K, Takei I, Umemoto M, Murakami M, Yamakado M, Yatomi Y, and Ohashi H: International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Investig, 2012; 3: 39-40

20) Kohara K, Okada Y, Ochi M, Ohara M, Nagai T, Tabara Y, and Igase M: Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study. J Cachexia Sarcopenia Muscle, 2017; 8: 557-566

21) Kim BJ, Lee SH, Kim CK, Ryu WS, Kwon HM, Choi SY, and Yoon BW: Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly. Circ J, 2011; 75: 451-456

22) Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C, and Wolf PA: Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke, 2009; 40: 1590-1596

23) Ooneda G: Pathology of stroke. Jpn Circ J, 1986; 50: 1224-1234

24) Martinez-Ramirez S, Greenberg SM, and Viswanathan A: Cerebral microbleeds: overview and implications in cognitive impairment. Alzheimers Res Ther, 2014; 6: 33

25) Suri MFK, Zhou J, Qiao Y, Chu H, Qureshi AI, Mosley T, Gottesman RF, Wruck L, Sharrett AR, Alonso A, and Wasserman BA: Cognitive impairment and intracranial atherosclerotic stenosis in general population. Neurology, 2018; 90:e1240-e1247

26) Appelman Y, van Rijn BB, Ten Haaf ME, Boersma E, and Peters SA: Sex differences in cardiovascular risk factors and disease prevention. Atherosclerosis, 2015; 241: 211- 218

27) Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Cushman M, Bild DE, and Burke GL: Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation, 2007; 115: 2722-2730

28) Matsui R, Nakagawa T, Takayoshi H, Onoda K, Oguro H, Nagai A, and Yamaguchi S: A prospective study of asymptomatic intracranial atherosclerotic stenosis in neurologically normal volunteers in a Japanese cohort. Front Neurol, 2016; 7: 39

29) Suri MFK, Qiao Y, Ma X, Guallar E, Zhou J, Zhang Y, Liu L, Chu H, Qureshi AI, Alonso A, Folsom AR, and Wasserman BA: Prevalence of intracranial atherosclerotic stenosis using high-resolution magnetic resonance angiography in the general population: the Atherosclerosis Risk in Communities Study. Stroke, 2016; 47: 1187-1193

30) Ogama N, Saji N, Niida S, Toba K, and Sakurai T: Validation of a simple and reliable visual rating scale of white matter hyperintensity comparable with computer-based volumetric analysis. Geriatr Gerontol Int, 2015; 15: 83-85

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