リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes

Nomura, Natsuko 京都大学 DOI:10.14989/doctor.k24838

2023.07.24

概要

Bronchiectasis is known to be an important comorbidity and differential diagnosis of severe asthma [1, 2].
Previous studies have shown that patients with asthma
complicated with bronchiectasis have refractory disease with frequent exacerbations [3], antibiotic use and
bronchopneumonia [4]. However, there is no appropriate guide for the management of bronchiectasis-complicated refractory asthma, which may arise from the
heterogeneous nature of this condition.
Asthma is typically characterised by eosinophilic,
type 2-high inflammation and bronchiectasis in asthma
has been commonly associated with allergic bronchopulmonary aspergillosis (ABPA), i.e., eosinophilic
bronchiectasis. Even in patients with asthma complicated with bronchiectasis other than ABPA, average
blood eosinophil counts are not decreased [1, 5]. Furthermore, studies on bronchiectasis without asthma
or ABPA have shown that eosinophilic predominant
phenotypes represented approximately 20% of patients
with bronchiectasis [6, 7]. Meanwhile, bronchiectasis has been typically characterised by recurrent airway infection and neutrophilic airway inflammation.
Low fractional exhaled nitric oxide (FeNO) levels have
been described as markers of comorbid bronchiectasis
in asthma [4] and infectious exacerbations in patients
treated with anti-interleukin (IL)-5 antibody for severe
asthma [8]. Collectively, patients with asthma with
comorbid bronchiectasis are heterogeneous, including
type 2-high and type 2-low phenotypes. However, their
characteristics and clinical courses according to inflammatory phenotypes remain unknown.
Furthermore, cases with bronchiectasis are often
accompanied by computed tomography (CT) findings
suggestive of chronic infectious bronchiolitis [9]. However, the effects of asthma with comorbid bronchiolitis have rarely been discussed, except for eosinophilic
bronchiolitis [10]. Thus, the purpose of this nationwide
study was to characterise patients with asthma complicated with bronchiectasis/bronchiolitis, clarify their
clinical courses by stratifying them through FeNO and
blood eosinophil counts, and examine the roles of these
two markers in patient management. ...

この論文で使われている画像

参考文献

1. Heffler E, Blasi F, Latorre M, Menzella F, Paggiaro P, Pelaia G, Senna G,

Canonica GW, Network S. The severe asthma network in italy: findings

and perspectives. J Allergy Clin Immunol Pract. 2019;7:1462–8.

2. Crimi C, Ferri S, Campisi R, Crimi N. The link between asthma and bronchiectasis: state of the art. Respiration. 2020;99:463–76.

3. Kang HR, Choi GS, Park SJ, Song YK, Kim JM, Ha J, Lee YH, Lee BH, Kim SH,

Lee JH. The effects of bronchiectasis on asthma exacerbation. Tuberc

Respir Dis (Seoul). 2014;77:209–14.

4. Padilla-Galo A, Olveira C, Fernández de Rota-Garcia L, Marco-Galve I,

Plata AJ, Alvarez A, Rivas-Ruiz F, Carmona-Olveira A, Cebrian-Gallardo JJ,

Martinez-Garcia MA. Factors associated with bronchiectasis in patients

with uncontrolled asthma; the NOPES score: a study in 398 patients.

Respir Res. 2018;19:43.

5. Matsumoto H. Bronchiectasis in severe asthma and asthmatic components in bronchiectasis. Respir Investig. 2022;60:187–96.

6. Tsikrika S, Dimakou K, Papaioannou AI, Hillas G, Thanos L, Kostikas K,

Loukides S, Papiris S, Koulouris N, Bakakos P. The role of non-invasive

modalities for assessing inflammation in patients with non-cystic fibrosis

bronchiectasis. Cytokine. 2017;99:281–6.

7. Shoemark A, Shteinberg M, De Soyza A, Haworth CS, Richardson H, Gao

Y, Perea L, Dicker AJ, Goeminne PC, Cant E, et al. Characterization of

eosinophilic bronchiectasis: A European Multicohort Study. Am J Respir

Crit Care Med. 2022;205:894–902.

8. McDowell PJ, Diver S, Yang F, Borg C, Busby J, Brown V, Shrimanker R, Cox

C, Brightling CE, Chaudhuri R, et al. The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving

mepolizumab (the MEX study): a prospective observational study. Lancet

Respir Med. 2021;9:1174–84.

9. Winningham PJ, Martínez-Jiménez S, Rosado-de-Christenson ML, Betancourt SL, Restrepo CS, Eraso A. Bronchiolitis: a practical approach for the

general radiologist. Radiographics. 2017;37:777–94.

10. Takayanagi N, Kanazawa M, Kawabata Y, Colby TV. Chronic bronchiolitis

with associated eosinophilic lung disease (eosinophilic bronchiolitis).

Respiration. 2001;68:319–22.

11. Tsang KW, Leung R, Fung PC, Chan SL, Tipoe GL, Ooi GC, Lam WK. Exhaled

and sputum nitric oxide in bronchiectasis: correlation with clinical parameters. Chest. 2002;121:88–94.

12. Huang YJ, Nariya S, Harris JM, Lynch SV, Choy DF, Arron JR, Boushey H.

The airway microbiome in patients with severe asthma: associations with

disease features and severity. J Allergy Clin Immunol. 2015;136:874–84.

13. Aoki A, Hirahara K, Kiuchi M, Nakayama T. Eosinophils: cells known for

over 140 years with broad and new functions. Allergol Int. 2021;70:3–8.

14. Kolsum U, Donaldson GC, Singh R, Barker BL, Gupta V, George L, Webb AJ,

Thurston S, Brookes AJ, McHugh TD, et al. Blood and sputum eosinophils

in COPD; relationship with bacterial load. Respir Res. 2017;18:88.

Page 12 of 13

15. Travers J, Rothenberg ME. Eosinophils in mucosal immune responses.

Mucosal Immunol. 2015;8:464–75.

16. Pulido D, Prats-Ejarque G, Villalba C, Albacar M, Gonzalez-Lopez JJ, Torrent

M, Moussaoui M, Boix E. A novel RNase 3/ECP peptide for Pseudomonas

aeruginosa biofilm eradication that combines antimicrobial, lipopolysaccharide binding, and cell-agglutinating activities. Antimicrob Agents

Chemother. 2016;60:6313–25.

17. Ho LP, Innes JA, Greening AP. Exhaled nitric oxide is not elevated in the

inflammatory airways diseases of cystic fibrosis and bronchiectasis. Eur

Respir J. 1998;12:1290–4.

18. American Thoracic S, European Respiratory S. ATS/ERS recommendations

for standardized procedures for the online and offline measurement of

exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J

Respir Crit Care Med. 2005;171:912–30.

19. Dressel H, de la Motte D, Reichert J, Ochmann U, Petru R, Angerer P, Holz

O, Nowak D, Jorres RA. Exhaled nitric oxide: independent effects of atopy,

smoking, respiratory tract infection, gender and height. Respir Med.

2008;102:962–9.

20. Bayarri MA, Milara J, Estornut C, Cortijo J. Nitric oxide system and bronchial epithelium: more than a barrier. Front Physiol. 2021;12: 687381.

21. Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and

disease of the respiratory system. Physiol Rev. 2004;84:731–65.

22. Barbier M, Agusti A, Alberti S. Fluticasone propionate reduces bacterial

airway epithelial invasion. Eur Respir J. 2008;32:1283–8.

23. Malo de Molina R, Mortensen EM, Restrepo MI, Copeland LA, Pugh MJ,

Anzueto A. Inhaled corticosteroid use is associated with lower mortality

for subjects with COPD and hospitalised with pneumonia. Eur Respir J.

2010;36:751–7.

24. O’Byrne PM, Pedersen S, Carlsson LG, Radner F, Thoren A, Peterson S, Ernst

P, Suissa S. Risks of pneumonia in patients with asthma taking inhaled

corticosteroids. Am J Respir Crit Care Med. 2011;183:589–95.

25. Heffler E, Madeira LNG, Ferrando M, Puggioni F, Racca F, Malvezzi L, Passalacqua G, Canonica GW. Inhaled corticosteroids safety and adverse effects

in patients with asthma. J Allergy Clin Immunol Pract. 2018;6:776–81.

26. McKeever T, Harrison TW, Hubbard R, Shaw D. Inhaled corticosteroids and

the risk of pneumonia in people with asthma: a case-control study. Chest.

2013;144:1788–94.

27. Beasley R, Harper J, Bird G, Maijers I, Weatherall M, Pavord ID. Inhaled

corticosteroid therapy in adult asthma. Time for a new therapeutic dose

terminology. Am J Respir Crit Care Med. 2019;199:1471–7.

28. Global Initiative for Asthma: Global Strategy for Asthma Management

and Prevention., May 17 2021 edition. https://​ginas​thma.​org/​wp-​conte​

nt/​uploa​ds/​2021/​05/​GINA-​Main-​Report-​2021-​V2-​WMS.​pdf; 2021.

29. Taylor SL, Leong LEX, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, et al. Inflammatory phenotypes in

patients with severe asthma are associated with distinct airway microbiology. J Allergy Clin Immunol. 2018;141(94–103): e115.

30. Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, Davies J, Ervine A,

Poulter L, Pachter L, et al. Disordered microbial communities in asthmatic

airways. PLoS ONE. 2010;5: e8578.

31. Denner DR, Sangwan N, Becker JB, Hogarth DK, Oldham J, Castillo J,

Sperling AI, Solway J, Naureckas ET, Gilbert JA, White SR. Corticosteroid

therapy and airflow obstruction influence the bronchial microbiome,

which is distinct from that of bronchoalveolar lavage in asthmatic airways. J Allergy Clin Immunol. 2016;137(1398–1405): e1393.

32. Henkle E, Curtis JR, Chen L, Chan B, Aksamit TR, Daley CL, Griffith DE,

Winthrop KL. Comparative risks of chronic inhaled corticosteroids and

macrolides for bronchiectasis. Eur Respir J. 2019;54:1801896.

33. Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, Murris M, Canton R, Torres A, Dimakou K, et al. European Respiratory Society guidelines for the management of adult bronchiectasis. Eur

Respir J. 2017;50:1700629.

34. Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM,

Israel E, Kraft M, Martin RJ, et al. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled

corticosteroid treatment. J Allergy Clin Immunol. 2017;140:63–75.

35. Ghebre MA, Pang PH, Diver S, Desai D, Bafadhel M, Haldar K, Kebadze

T, Cohen S, Newbold P, Rapley L, et al. Biological exacerbation clusters

demonstrate asthma and chronic obstructive pulmonary disease overlap

with distinct mediator and microbiome profiles. J Allergy Clin Immunol.

2018;141(2027–2036): e2012.

Nomura et al. Respiratory Research

(2022) 23:365

Page 13 of 13

36. King PT. The pathophysiology of bronchiectasis. Int J Chron Obstruct

Pulmon Dis. 2009;4:411–9.

37. Chang AB, Upham JW, Masters IB, Redding GR, Gibson PG, Marchant JM,

Grimwood K. Protracted bacterial bronchitis: the last decade and the road

ahead. Pediatr Pulmonol. 2016;51:225–42.

38. Takemura M, Niimi A, Minakuchi M, Matsumoto H, Ueda T, Chin K,

Mishima M. Bronchial dilatation in asthma: relation to clinical and sputum

indices. Chest. 2004;125:1352–8.

39. Polverino E, Dimakou K, Hurst J, Martinez-Garcia MA, Miravitlles M,

Paggiaro P, Shteinberg M, Aliberti S, Chalmers JD. The overlap between

bronchiectasis and chronic airway diseases: state of the art and future

directions. Eur Respir J. 2018;52:1800328.

40. Mäntylä J, Mazur W, Törölä T, Bergman P, Saarinen T, Kauppi P. Asthma as

aetiology of bronchiectasis in Finland. Respir Med. 2019;152:105–11.

41. Aliberti S, Goeminne PC, O’Donnell AE, Aksamit TR, Al-Jahdali H, Barker

AF, Blasi F, Boersma WG, Crichton ML, De Soyza A, et al. Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults

for use in clinical trials: international consensus recommendations. Lancet

Respir Med. 2022;10:298–306.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Ready to submit your research ? Choose BMC and benefit from:

• fast, convenient online submission

• thorough peer review by experienced researchers in your field

• rapid publication on acceptance

• support for research data, including large and complex data types

• gold Open Access which fosters wider collaboration and increased citations

• maximum visibility for your research: over 100M website views per year

At BMC, research is always in progress.

Learn more biomedcentral.com/submissions

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る