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書き出し
The interferon-stimulated gene product HELZ2 destabilizes human LINE-1 RNA to inhibit LINE-1 retrotransposition and the associated type I interferon response
概要
1.1 Transposable elements in the human genome
Initial report of human genome sequencing revealed an intriguing fact that the coding
regions are extremely small in comparison to the non-coding ones; the coding regions only
cover approximately ~1.5% of the human genome, and are estimated to consist of ~20,000
genes (Lander et al., 2001; Venter et al., 2001). The rest of the genome is non-coding and
initially viewed as ‘’junk DNA’’. The relatively huge fraction of the non-coding regions begs
the question of how many of them are physiologically relevant. ...
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