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Detection of Pulmonary Embolism Using a Novel Dynamic Flat-Panel Detector System in Monkeys.

MIYATA Hisae TABATA Takahisa 90278200 TSUJITA Yasuyuki 60343224 FUJINO Kazunori 70402716 TANAKA Rie EGUCHI Yutaka 00263054 滋賀医科大学

2021.03.25

概要

Background:
Recently, dynamic chest radiography (DCR) was developed to evaluate pulmonary function using a flat-panel detector (FPD), which can evaluate blood flow in the pulmonary artery without injection of contrast agents. This study investigated the ability of a FPD to measure physiological changes in blood flow and to detect pulmonary embolism (PE) in monkeys.
Methods and Results:
DCR was performed in 5 monkeys using a FPD. Regions of interest (ROI) were placed in both lung fields of the image, and maximum changes in pixel value (∆pixel value) in the ROI were measured during 1 electrocardiogram cardiac cycle. Next, a PE model was induced using a Swan-Ganz catheter and additional images were taken. The ∆pixel value of the lungs in normal and PE models were compared in both supine and standing positions. The lung ∆pixel value followed the same cycle as the monkey electrocardiogram. ∆pixel values in the upper lung field decreased in the standing as compared to the supine position. In the PE model, the ∆pixel value decreased in the area of pulmonary blood flow occlusion and increased in the contralateral lung as compared to the normal model (normal model 1.287±0.385, PE model occluded side 0.428±0.128, PE model non-occluded side 1.900±0.431).
Conclusions:
A FPD could detect postural changes in pulmonary blood flow and its reduction caused by pulmonary artery occlusion in a monkey model.

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Supplementary Files

Supplementary Movie. Dynamic chest radiography (DCR) images of

the normal model (Left upper), color maps of the normal model

(Right upper), DCR of the right PE model (Left lower) and color

maps of the right PE model (Right lower). In the color maps,

increases in pixel value changes are shown in blue and decreases in

red.

Please find supplementary file(s);

http://dx.doi.org/10.1253/circj.CJ-20-0835

Circulation Journal Vol.85, April 2021

...

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