Albrektsson, T., Chrcanovic, B., O¨ stman, P.O., Sennerby, L., 2017. Initial and long-term crestal bone responses to modern dental implants. Periodontol 73, 41–50. https:// doi.org/10.1111/prd.12176, 2000.
Allison, H., McNamara, L.M., 2019. Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency. Am. J. Physiol. Cell Physiol. 317, C969–C982. https://doi.org/10.1152/ajpcell.00168.2019.
Alsaadi, G., Quirynen, M., Koma´rek, A., Van Steenberghe, D., 2007. Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection. J. Clin. Periodontol. 34, 610–617. https://doi.org/10.1111/j.1600- 051X.2007.01077.x.
Atkins, G.J., Findlay, D.M., 2012. Osteocyte regulation of bone mineral: a little give and take. Osteoporos. Int. 23, 2067–2079. https://doi.org/10.1007/s00198-012-1915-z.
August, M., Chung, K., Chang, Y., Glowacki, J., 2001. Influence of estrogen status on endosseous implant osseointegration. J. Oral Maxillofac. Surg. 59, 1285–1289. https://doi.org/10.1053/joms.2001.27515.
Bagi, C.M., Berryman, E., Moalli, M.R., 2011. Comparative bone anatomy of commonly used laboratory animals: implications for drug discovery. Comp. Med. 61, 76–85.
Bellido, T., 2014. Osteocyte-driven bone remodeling. Calcif. Tissue Int. 94, 25–34. https://doi.org/10.1007/s00223-013-9774-y.
Bidez, M.W., Misch, C.E., 1992. Issue in bone mechanics related to oral implants. Implant Dent. 1, 289–294. https://doi.org/10.1097/00008505-199200140-00011.
Bruker, 2013. Bone Mineral Density (BMD) and Tissue Mineral Density (TMD) Calibration and Measurement Using Bruker microCT BMD Phantoms and CT- Analyser Software. Bruker, Kontich, Belgium.
Burr, D.B., Hooser, M., 1995. Alterations to the en bloc basic fuchsin staining protocol for the demonstration of microdamage produced in vivo. Bone 17, 431–433. https://doi. org/10.1016/S8756-3282(95)00241-3.
Delgado-Ruiz, R.A., Calvo-Guirado, J.L., Romanos, G.E., 2019. Effects of occlusal forces on the peri-implant-bone interface stability. Periodontol 81, 179–193. https://doi. org/10.1111/prd.12291, 2000.
Dobbs, M.B., Buckwalter, J., Saltzman, C., 1999. Osteoporosis: the increasing role of the orthopaedist. Iowa Orthop. J. 19, 43–52.
Du, Z., Steck, R., Doan, N., Woodruff, M.A., Ivanovski, S., Xiao, Y., 2015. Estrogen deficiency-associated bone loss in the maxilla: a methodology to quantify the changes in the maxillary intra-radicular alveolar bone in an ovariectomized rat osteoporosis model. Tissue Eng. C Methods 21, 458–466. https://doi.org/10.1089/ ten.tec.2014.0268.
Duarte, P.M., Cesar Neto, J.B., Gonçalves, P.F., Sallum, E.A., Nociti, F.H., 2003. Estrogen deficiency affects bone healing around titanium implants: a histometric study in rats. Implant Dent. 12, 340–346. https://doi.org/10.1097/01.ID.0000099750.26582.4b.
Duyck, J., Rønold, H.J., Van Oosterwyck, H., Naert, I., Vander Sloten, J., Ellingsen, J.E., 2001. The influence of static and dynamic loading on marginal bone reactions around osseointegrated implants: an animal experimental study. Clin. Oral Implants Res. 12, 207–218. https://doi.org/10.1034/j.1600-0501.2001.012003207.x.
Esaki, D., Matsushita, Y., Ayukawa, Y., Sakai, N., Sawae, Y., Koyano, K., 2012. Relationship between magnitude of immediate loading and peri-implant osteogenesis in dogs. Clin. Oral Implants Res. 23, 1290–1296. https://doi.org/ 10.1111/j.1600-0501.2011.02305.x.
Esposito, M., Thomsen, P., Ericson, L.E., Sennerby, L., Lekholm, U., 2000. Histopathologic observations on late oral implant failures. Clin. Implant Dent. Relat. Res. 2, 18–32. https://doi.org/10.1111/j.1708-8208.2000.tb00103.x.
Fujii, N., Kusakari, H., Maeda, T., 1998. A histological study on tissue responses to titanium implantation in rat maxilla: the process of epithelial regeneration and bone reaction. J. Periodontol. 69, 485–495. https://doi.org/10.1902/jop.1998.69.4.485.
Futami, T., Fujii, N., Ohnishi, H., Taguchi, N., Kusakari, H., Ohshima, H., Maeda, T., 2000. Tissue response to titanium implants in the rat maxilla: ultrastructural and histochemical observations of the bone-titanium interface. J. Periodontol. 71, 287–298. https://doi.org/10.1902/jop.2000.71.2.287.
Giro, G., Coelho, P.G., Pereira, R.M.R., Jorgetti, V., Marcantonio, E., Orrico, S.R.P., 2011. The effect of oestrogen and alendronate therapies on postmenopausal bone loss around osseointegrated titanium implants. Clin. Oral Implants Res. 22, 259–264. https://doi.org/10.1111/j.1600-0501.2010.01989.x.
Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy, G.R., Boyce, B.F., 1996. Estrogen promotes apoptosis of murine osteoclasts mediated byTGF-P. Nat. Med. 2, 1132–1136. https://doi.org/10.1038/nm1096-1132.
Isidor, F., 1996. Loss of osseointegration caused by occlusal load of oral implants: a clinical and radiographic study in monkeys. Clin. Oral Implants Res. 7, 143–152. https://doi.org/10.1034/j.1600-0501.1996.070208.x.
Isidor, F., 2006. Influence of forces on peri-implant bone. Clin. Oral Implants Res. 2, 8–18. https://doi.org/10.1111/j.1600-0501.2006.01360.x.
Ji, M.X., Yu, Q., 2015. Primary osteoporosis in postmenopausal women. Chronic Dis. Transl. Med. 1, 9–13. https://doi.org/10.1016/j.cdtm.2015.02.006.
Johnston, B.D., Ward, W.E., 2015. The ovariectomized rat as a model for studying alveolar bone loss in postmenopausal women. BioMed Res. Int. https://doi.org/ 10.1155/2015/635023.
Joldersma, M., Klein-Nulend, J., Oleksik, A.M., Heyligers, I.C., Burger, E.H., 2001. Estrogen enhances mechanical stress-induced prostaglandin production by bone cells from elderly women. Am. J. Physiol. Endocrinol. Metab. 280, 436–442. https://doi. org/10.1152/ajpendo.2001.280.3.e436.
Kalu, D.N., 1991. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15, 175–191. https://doi.org/10.1016/0169-6009(91)90124-I.
Kameda, T., Mano, H., Yuasa, T., Mori, Y., Miyazawa, K., Shiokawa, M., Nakamaru, Y., Hiroi, E., Hiura, K., Kameda, A., Yang, N.N., Hakeda, Y., Kumegawa, M., 1997. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone- resorbing osteoclasts. J. Exp. Med. 186, 489–495. https://doi.org/10.1084/ jem.186.4.489.
Kharode, Y.P., Sharp, M.C., Bodine, P.V.N., 2008. Utility of the ovariectomized rat as a model for human osteoporosis in drug discovery. Methods Mol. Biol. 455, 111–124. https://doi.org/10.1007/978-1-59745-104-8_8.
Kim, Y., Oh, T.J., Misch, C.E., Wang, H.L., 2005. Occlusal considerations in implant therapy: clinical guidelines with biomechanical rationale. Clin. Oral Implants Res. 16, 26–35. https://doi.org/10.1111/j.1600-0501.2004.01067.x.
Klein-Nulend, J., Bacabac, R.G., Bakker, A.D., 2012. Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton. Eur. Cell. Mater. 24, 278–291. https://doi.org/10.22203/eCM.v024a20.
Kousteni, S., Bellido, T., Plotkin, L.I., O’Brien, C.A., Bodenner, D.L., Han, L., Han, K., DiGregorio, G.B., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Roberson, P.K., Weinstein, R.S., Jilka, R.L., Manolagas, S.C., 2001. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104, 719–730. https://doi.org/10.1016/s0092-8674(01)00268-9.
Li, X., Ominsky, M.S., Niu, Q.T., Sun, N., Daugherty, B., D’Agostin, D., Kurahara, C., Gao, Y., Cao, J., Gong, J., Asuncion, F., Barrero, M., Warmington, K., Dwyer, D., Stolina, M., Morony, S., Sarosi, I., Kostenuik, P.J., Lacey, D.L., Simonet, W.S., Ke, H. Z., Paszty, C., 2008. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J. Bone Miner. Res. 23, 860–869. https://doi.org/10.1359/jbmr.080216.
Li, Y., He, S., Hua, Y., Hu, J., 2017. Effect of osteoporosis on fixation of osseointegrated implants in rats. J. Biomed. Mater. Res. B Appl. Biomater. 105, 2426–2432. https:// doi.org/10.1002/jbm.b.33787.
Manolagas, S.C., 2000. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21, 115–137. https://doi.org/10.1210/edrv.21.2.0395.
Mattheos, N., Schittek Janda, M., Zampelis, A., Chronopoulos, V., 2013. Reversible, Non- plaque-induced loss of osseointegration of successfully loaded dental implants. Clin. Oral Implants Res. 24, 347–354. https://doi.org/10.1111/clr.12009.
Merheb, J., Temmerman, A., Rasmusson, L., Kübler, A., Thor, A., Quirynen, M., 2016. Influence of skeletal and local bone density on dental implant stability in patients with osteoporosis. Clin. Implant Dent. Relat. Res. 18, 253–260. https://doi.org/ 10.1111/cid.12290.
Munhoz, E.A., Bodanezi, A., Cestari, T.M., Taga, R., Ferreira Junior, O., de Carvalho, P.S. P., 2011. Biomechanical and microscopic response of bone to titanium implants in the presence of inorganic grafts. J. Oral Implantol. 37, 19–25. https://doi.org/ 10.1563/AAID-JOI-D-09-00086.
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W. J., Clark, A., Cuthill, I.C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S.T., Howells, D.W., Karp, N.A., Lazic, S.E., Lidster, K., MacCallum, C.J., Macleod, M., Pearl, E.J., Petersen, O.H., Rawle, F., Reynolds, P., Rooney, K., Sena, E.S., Silberberg, S.D., Steckler, T., Würbel, H., 2020. The arrive guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 18, e3000410 https://doi.org/ 10.1371/journal.pbio.3000410.
Ruffoni, D., Müller, R., Van Lenthe, G.H., 2012. Mechanisms of reduced implant stability in osteoporotic bone. Biomech. Model. Mechanobiol. 11, 313–323. https://doi.org/ 10.1007/s10237-011-0312-4.
Sozen, T., Ozisik, L., Basaran, N.C., 2017. An overview and management of osteoporosis. Eur. J. Rheumatol. 4, 46–56. https://doi.org/10.5152/eurjrheum.2016.048.
Takemura, Y., Moriyama, Y., Ayukawa, Y., Kurata, K., Rakhmatia, Y.D., Koyano, K., 2019. Mechanical loading induced osteocyte apoptosis and connexin 43 expression in three-dimensional cell culture and dental implant model. J. Biomed. Mater. Res. 107, 815–827. https://doi.org/10.1002/jbm.a.36597.
Tomkinson, A., Gevers, E.F., Wit, J.M., Reeve, J., Noble, B.S., 1998. The role of estrogen in the control of rat osteocyte apoptosis. J. Bone Miner. Res. 13, 1243–1250. https:// doi.org/10.1359/jbmr.1998.13.8.1243.
Van der Meulen, M.C., Jepsen, K.J., Miki´c, B., 2001. Understanding bone strength: size isn’t everything. Bone 29, 101–104. https://doi.org/10.1016/S8756-3282(01)00491-4.
Viera-Negron, Y.E., Ruan, W., Winger, J.N., Hou, X., Sharawy, M.M., Borke, J.L., 2008. Effect of ovariectomy and alendronate on implant osseointegration in rat maxillary bone. J. Oral Implantol. 34, 76–82. https://doi.org/10.1563/1548-1336(2008)34 [76:EOOAAO]2.0.CO;2.
Winkler, D.G., Sutherland, M.K., Geoghegan, J.C., Yu, C., Hayes, T., Skonier, J.E., Shpektor, D., Jonas, M., Kovacevich, B.R., Staehling-Hampton, K., Appleby, M., Brunkow, M.E., Latham, J.A., 2003. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 22, 6267–6276. https://doi.org/ 10.1093/emboj/cdg599.
Wirth, A.J., Goldhahn, J., Flaig, C., Arbenz, P., Müller, R., Van Lenthe, G.H., 2011. Implant stability is affected by local bone microstructural quality. Bone 49, 473–478. https://doi.org/10.1016/j.bone.2011.05.001.
Wronski, T.J., Dann, L.M., Scott, K.S., Cintro´n, M., 1989. Long-term effects of ovariectomy and aging on the rat skeleton. Calcif. Tissue Int. 45, 360–366. https:// doi.org/10.1007/BF02556007.
Yamazaki, M., Shirota, T., Tokugawa, Y., Motohashi, M., Ohno, K., Michi, K., Yamaguchi, A., 1999. Bone reactions to titanium screw implants in ovariectomized animals. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 87, 411–418. https:// doi.org/10.1016/S1079-2104(99)70239-8.