Cover and contents etc.

概要

TITLE:

Cover and contents etc.

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CITATION:

Cover and contents etc.. KURNS Progress Report 2021, 2020

ISSUE DATE:
2021-08

URL:
http://hdl.handle.net/2433/265003
RIGHT:

ISSN 2434-9488

2020

KURNS Progress Report 2020
APRIL 2020 – MARCH 2021

Published by
Institute for Integrated Radiation and Nuclear Science,
Kyoto University,
Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan

Preface for the KURNS Progress Report 2020

It is our pleasure to announce that the KURNS Progress Report 2020 has been published. This
report contains all of the accomplishments of research and related activities at the Institute for
Integrated Radiation and Nuclear Science, Kyoto University (KURNS) during the fiscal year 2020
(hereafter called as FY2020). A large number of research subjects has been enrolled also in
FY2020, which covers various fields of nuclear science and technology, material science, radiation
life science and radiation medical science. It means that our institute continues to play a distinctive
role as a Joint Usage/Research Center, promoting an extensive range of studies from fundamental
to applied research with research reactors and accelerators.
In FY2020, our activity was drastically restricted due to the COVIT-19 pandemic. During the
1st period of a state of emergency issued for Osaka prefecture (from April 17 to May 21, 2020), all
the activity related to the preparation for the operation of the joint research facilities including KUR
and KUCA was suspended, therefore the operation time for these facilities decreased significantly.
Note that the activity on the safety management was still continued under the corresponding
period. In FY 2020, KUR was operated for 570 hours and KUCA was for 152 hours. In total, we
accepted 2,560 man-day researchers and students for using research facilities and for attending
scientific meetings. Because of the operation time reduction, some of the research subjects
were carried forward to FY2021.
We strive for safe and stable operations for nationwide use, making it our primary mission to
provide scientists the opportunity to conduct research and education. We are happy to dedicate our
support to enable users conduct significant interdisciplinary research at KURNS.
Kumatori, July 12, 2021
Ken Nakajima
Director, KURNS

CONTENTS
I. ANNUAL SUMMARY OF EXPERIMENTAL RESEARCH ACTIVITIES ................................................

1

I-1. PROJECT RESEARCHES ...........................................................................................................................

2

Project 1

Analyzing Tumor Microenvironment and Exploiting its Characteristics in Search of
Optimizing Cancer Therapy Including Neutron Capture Therapy
S. Masunaga (R2P1) ...................................................................................................................

3

Significance of combination with both continuous administration of hypoxic cytotoxin,
tirapazamine and mild temperature hyperthermia in BNCT in terms of local tumor
control and lung metastatic potential
S. Masunaga et al. (R2P1-1) ······································································· ·

4

PR1-2

Development of Amino Acid Derivatives Containing 10B-Clusters for BNCT
A. Matsushita et al. (R2P1-2) ·······································································

5

PR1-3

Proteolysis of a Histone Acetyl Reader Protein Induces Chemoresistance of Cancer Cells
under Hypoxia by Inhibiting Cell Cycle Progression in S Phase
T. Haitani et al. (R2P1-3) ············································································

6

Cancer-Targeting Hyaluronic Acid/Carboranyl Pyrene Complex for Boron Neutron Capture
Therapy
K. Yamana et al. (R2P1-6) ···········································································

7

PR1-5

An evaluation of stratified mouse model and the response of tumor cells to BNCT
S. Imamichi et al. (R2P1-9) ·········································································

8

PR1-6

Attempts to sensitize tumor cells by exploiting the tumor microenvironment
Y. Sanada et al. (R2P1-12) ··········································································

9

Project Research on Advances in Isotope-Specific Studies Using Muti-Element Mössbauer
Spectroscopy
M. Seto (R2P2) ····························································································

11

Peak intensity of quadrupole doublet of cordierite by single crystal Mössbauer
microspectros-copy
K. Shinoda, Y. Kobayashi (R2P2-1) ·······························································

12

PR2-2

Low-Temperature Behavior of Mössbauer Spectra for Fe2O3-Al2O3 Solid Solution
S. Takai et al. (R2P2-2) ··············································································

13

PR2-3

Characterization of steel microstructure using Mössbauer spectroscopy
G. Miyamoto et al. (R2P2-3) ········································································

14

PR2-4

Mössbauer study of Diluted Iron Nanoparticles
R. Masuda et al. (R2P2-4) ···········································································

15

PR2-5

Research on magnetism in a novel Kondo Lattice II
Y. Kamihara et al. (R2P2-5) ·········································································

16

PR2-6

Recoil-free fraction in 197Au Mössbauer Spectroscopy for precursor of supported gold cluster
catalysts
H. Ohashi et al. (R2P2-6) ············································································ 17

PR2-7

Sn Mössbauer Study of Absorbed Sn on Metallic Oxide
Y. Kobayashi et al. (R2P2-7) ········································································

18

PR2-8

Development of Single-Line Compounds for Er Mössbauer Spectroscopy
S. Kitao et al. (R2P2-8) ··············································································

19

The effect of boron neutron capture therapy on normal tissues
M. Suzuki (R2P4) .......................................................................................................................

21

The effect of boron neutron capture therapy (BNCT) on normal lung in mice
M. Suzuki, Y. Tamari (R2P4-1) ............................................................................................

22

PR1-1

PR1-4

Project 2

PR2-1

Project 4
PR4-1

119

166

i

PR4-2

Clarification of the normal cell fractionation as a trigger for radiation-induced liver injury
S. Takeno, M. Suzuki (R2P4-2) ............................................................................................

23

PR4-3

The biological effect on neurons and brain blood vessels induced by Boron Neutron
Capture Therapy
N. Kondo et al. (R2P4-3) ············································································

24

The Effect of Boron Neutron Capture Therapy to Normal Bones in Mice
R. Iwasaki et al. (R2P4-5) ....................................................................................................

25

Preclinical studis on gadolinium neutron capture therapy
M. Suzuki (R2P5) ·························································································

27

Investigation of cell killing effect by auger electrons emitted during gadolinium neutron
capture therapy (Gd-NCT)
M. Suzuki, H. Tanaka (R2P5-1) ····································································

28

PR5-2

Development of Nano Carriers Installed with Gd(III)-Thiacalixarene Complex for Gd-NCT
N. Iki et al. (R2P5-2) ·················································································

29

PR5-3

Gadolinium neutron capture therapy as new treatment for head and neck cancer
T. Andoh et al. (R2P5-3) ·············································································

30

PR5-4

Preparation of functional molecules with Hoechst unit
K. Tanabe et al. (R2P5-5) ············································································

31

PR5-5

Development of Gadolinium-loaded mesoporous silica-based nanoparticles and application to
cancer radiotherapy
F. Tamanoi et al. (R2P5-6) ··········································································

32

PR4-4

Project 5
PR5-1

PR5-6

Evaluation of Antitumor effectivity by Gd-neutron capture therapy using Gd2O3 incorporated
nanomicelle
H. Xuan et al. (R2P5-7) ·············································································· 33

PR5-7

Development of 10B-enriched GdBO3 nanoparticles for neutron capture therapy of cancer
Li Zhao et al. (R2P5-8)················································································

34

PR5-8

Study about neutron capture therapy using polymeric drug delivery systems chelating Gd
Y. Miura et al. (R2P5-9)···············································································

35

PR5-9

In vivo dose-dependent administration study in mice of Gd-EDTMP: gadolinium neutron
capture therapy formulation for bone metastasis
T. Matsukawa et al. (R2P5-10) ·······································································

36

Enhancement of research methods for material irradiation and defect analysis
A. Kinomura (R2P6) ······················································································

38

PR6-1

Study to improve transport and measurement performance of a slow positron beamline
A. Kinomura et al. (R2P6-1) ··········································································

39

PR6-2

Doping effect of Re, Mo, Ta on electron-irradiation induced defects in W
T. Toyama et al. (R2P6-2)·············································································

40

PR6-3

Change in the Positron Annihilation Lifetime of Electron-irradiated F82H by Hydrogen
Charging 2
K. Sato et al. (R2P6-3) ················································································

41

PR6-4

Gamma-ray induced light emission from GaN single crystal wafer
T. Nakamura et al. ...