1. Labrie, F. Intracrinology. Mol. Cell. Endocrinol. 78, C113–C118 (1991).
2. Labrie, F., Martel, C., Belanger, A. & Pelletier, G. Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology. J. Steroid Biochem. Mol. Biol. 168, 9–18 (2017).
3. Bron, A. J. et al. TFOS DEWS II pathophysiology report. Ocul. Surf. 15, 438–510 (2017).
4. Knop, E., Knop, N., Millar, T., Obata, H. & Sullivan, D. A. The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest. Ophthalmol. Vis. Sci. 52, 1938–1978 (2011).
5. Jones, L. et al. TFOS DEWS II management and therapy report. Ocul. Surf. 15, 575–628 (2017).
6. Simard, J. et al. Molecular biology of the 3β-hydroxysteroid dehydrogenase/δ5-δ4 isomerase gene family. Endocr. Rev. 26, 525–582 (2005).
7. Perra, M. T. et al. Human meibomian glands: a histochemical study for androgen metabolic enzymes. Invest. Ophthalmol. Vis. Sci. 31, 771–775 (1990).
8. Doi, M. et al. Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism. J. Clin. Endocrinol. Metab. 99, E257–E262 (2014).
9. Chen, X. et al. Are BALB/c mice relevant models for understanding sex-related differences in gene expression in the human meibomian gland? Cornea 38, 1554–1562 (2019).
10. Doi, M. et al. Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat. Med. 16, 67–74 (2010).
11. Indra, A. K. et al. Targeted somatic mutagenesis in mouse epidermis. Horm. Res. 54, 296–300 (2000).
12. Inaba, T. et al. Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency. Sci. Rep. 8, 3358 (2018).
13. Sahin, A., Liu, Y., Kam, W. R., Darabad, R. R. & Sullivan, D. A. Dihydrotestosterone suppression of proinflammatory gene expression in human meibomian gland epithelial cells. Ocul. Surf. 18, 199–205 (2020).
14. Obata, H. Anatomy and histopathology of human meibomian gland. Cornea 21, S70–S74 (2002).
15. Clevers, H. & Nusse, R. Wnt/β-catenin signaling and disease. Cell 149, 1192–1205 (2012).
16. Kelwick, R., Desanlis, I., Wheeler, G. N. & Edwards, D. R. The ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs) family. Genome Biol. 16, 113 (2015).
17. Xie, H. T. et al. Biomarkers for progenitor and differentiated epithelial cells in the human meibomian gland. Stem Cells Transl. Med 7, 887–892 (2018).
18. Yoo, S. H. et al. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl Acad. Sci. USA 101, 5339–5346 (2004).
19. Fustin, J. M. et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell 155, 793–806 (2013).
20. Field, M. D. et al. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms. Neuron 25, 437–447 (2000).
21. Yamamura, K. et al. Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta. Mol. Cell. Endocrinol. 382, 131–138 (2014).
22. Bunger, M. K. et al. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103, 1009–1017 (2000).
23. Thomas, J. L., Mason, J. I., Brandt, S., Spencer, B. R. Jr. & Norris, W. Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3β-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J. Biol. Chem. 277, 42795–42801 (2002).
24. Verdin, E. NAD(+) in aging, metabolism, and neurodegeneration. Science 350, 1208–1213 (2015).
25. Yoshino, J., Baur, J. A. & Imai, S. I. NAD(+) intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab. 27, 513–528 (2018).
26. Yager, J. D. & Davidson, N. E. Estrogen carcinogenesis in breast cancer. N. Engl. J. Med. 354, 270–282 (2006).
27. Basaria, S. et al. Adverse events associated with testosterone administration. N. Engl. J. Med. 363, 109–122 (2010).
28. Geerling, G. et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest. Ophthalmol. Vis. Sci. 52, 2050–2064 (2011).
29. Levine, D. C. et al. NAD(+) controls circadian reprogramming through PER2 nuclear translocation to counter aging. Mol. Cell 78, 835–849 (2020).
30. Mills, K. F. et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 24, 795–806 (2016).
31. Lin, J. B. et al. NAMPT-mediated NAD(+) biosynthesis is essential for vision in mice. Cell Rep. 17, 69–85 (2016).
32. Asano, N., Ueda, K. & Kawazu, K. Penetration route of the selective glucocorticoid receptor agonist SA22465 and betamethasone into rabbit meibomian gland based on pharmacokinetics and autoradiography. Drug Metab. Dispos. 45, 826–833 (2017).
33. Brundl, M., Garreis, F., Schicht, M., Dietrich, J. & Paulsen, F. Characterization of the innervation of the meibomian glands in humans, rats and mice. Ann. Anat. 233, 151609 (2021).
34. Sullivan, B. D., Evans, J. E., Krenzer, K. L., Reza Dana, M. & Sullivan, D. A. Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. J. Clin. Endocrinol. Metab. 85, 4866–4873 (2000).
35. Krenzer, K. L. et al. Effect of androgen deficiency on the human meibomian gland and ocular surface. J. Clin. Endocrinol. Metab. 85, 4874–4882 (2000).
36. Tsubota, K. et al. New perspectives on dry eye definition and diagnosis: a consensus report by the Asia Dry Eye Society. Ocul. Surf. 15, 65–76 (2017).
37. Shimba, S. et al. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS ONE 6, e25231 (2011).
38. Doi, M. et al. Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity. Nat. Commun. 10, 2563 (2019).
39. Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V. & Antoch, M. P. Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev. 20, 1868–1873 (2006).
40. Yang, G. et al. Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci. Transl. Med. 8, 324ra316 (2016).
41. Takeo, E. et al. Tandem mass spectrometry imaging reveals distinct accumulation patterns of steroid structural isomers in human adrenal glands. Anal. Chem. 91, 8918–8925 (2019).
42. Star-Weinstock, M., Williamson, B. L., Dey, S., Pillai, S. & Purkayastha, S. LC-ESI-MS/MS analysis of testosterone at sub-picogram levels using a novel derivatization reagent. Anal. Chem. 84, 9310–9317 (2012).
43. Shinomiya, K., Ueta, M. & Kinoshita, S. A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision. Sci. Rep. 8, 1483 (2018).
44. Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013).
45. Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576–589 (2010).
46. Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
47. Doi, M. et al. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat. Commun. 7, 10583 (2016).
48. Ota, T. et al. Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3β-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1. Mol. Cell. Biol. 34, 3880–3894 (2014).
49. Yoshino, J. & Imai, S. Accurate measurement of nicotinamide adenine dinucleotide (NAD(+)) with high-performance liquid chromatography. Methods Mol. Biol. 1077, 203–215 (2013).
50. Hughes, M. E., Hogenesch, J. B. & Kornacker, K. JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J. Biol. Rhythms 25, 372–380 (2010).
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