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A novel HIF inhibitor halofuginone prevents neurodegeneration in a murine model of retinal ischemia-reperfusion (本文)

國見, 洋光 慶應義塾大学

2020.03.23

概要

Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis and revealed that HIF inhibition may be effective against retinal neovascular and neurodegeneration. In this study, we performed in vitro screening of natural products and found halofuginone, which is a derivative of febrifugine extracted from hydrangea, as a novel HIF inhibitor. Administration of halofuginone showed a significant neuroprotective effect by inhibiting HIF-1α expression in a murine retinal ischemia-reperfusion model histologically and functionally. These results indicate that halofuginone can be a neuroprotective agent in ischemic retinal degenerative diseases.

参考文献

1. Semenza, G.L. Regulation of Metabolism by Hypoxia-Inducible Factor 1. Cold Spring Harb. Symp. Quant. Biol. 2011, 76, 347–353. [CrossRef] [PubMed]

2. Ozaki, H.; Yu, A.Y.; Della, N.; Ozaki, K.; Luna, J.D.; Yamada, H.; Hackett, S.F.; Okamoto, N.; Zack, D.J.; Semenza, G.L.; et al. Hypoxia inducible factor-1α is increased in ischemic retina: Temporal and spatial correlation with VEGF expression. Investig. Ophthalmol. Vis. Sci. 1999, 40, 182–189.

3. Tezel, G.; Wax, M.B. Hypoxia-inducible factor 1α in the glaucomatous retina and optic nerve head. Arch. Ophthalmol. 2004, 122, 1348–1356. [CrossRef] [PubMed]

4. Rapisarda, A.; Uranchimeg, B.; Scudiero, D.A.; Selby, M.; Sausville, E.A.; Shoemaker, R.H.; Melillo, G. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 2002, 62, 4316–4324. [PubMed]

5. Lee, K.; Qian, D.Z.; Rey, S.; Wei, H.; Liu, J.O.; Semenza, G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. USA 2009, 106, 2353–2358. [CrossRef] [PubMed]

6. Müller, M.; Kersten, S. Nutrigenomics: Goals and strategies. Nat. Rev. Genet. 2003, 4, 315–322. [CrossRef] [PubMed]

7. Trayhurn, P. Nutritional genomics – “Nutrigenomics”. Br. J. Nutr. 2003, 89, 1–2. [CrossRef] [PubMed]

8. Chuaqui, R.F.; Bonner, R.F.; Best, C.J.M.; Gillespie, J.W.; Flaig, M.J.; Hewitt, S.M.; Phillips, J.L.; Krizman, D.B.; Tangrea, M.A.; Ahram, M.; et al. Post-analysis follow-up and validation of microarray experiments. Nat. Genet. 2002, 32, 509. [CrossRef] [PubMed]

9. Delcourt, C. Application of Nutrigenomics in Eye Health. In Forum of Nutrition; Karger Publishers: Basel, Switzerland, 2007; Volume 60, pp. 168–175. ISBN 1660-0347.

10. Fine, I.H. A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation with Vitamins C and E and Beta-Carotene for Age-Related Cataract and Vision Loss. Evidence-Based Eye Care 2003, 3, 80–81. [CrossRef]

11. Schalch, W.; Chylack, L.T. Antioxidative Mikronährstoffe und Katarakt. Der. Ophthalmol. 2003, 100, 181–189. [CrossRef]

12. Dátilo, M.N.; Sant’Ana, M.R.; Formigari, G.P.; Rodrigues, P.B.; de Moura, L.P.; da Silva, A.S.R.; Ropelle, E.R.; Pauli, J.R.; Cintra, D.E. Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor. Sci. Rep. 2018, 8, 1–13. [CrossRef] [PubMed]

13. Mori, K.; Kurihara, T.; Miyauchi, M.; Ishida, A.; Jiang, X.; Ikeda, S.; Torii, H.; Tsubota, K. Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia. Sci. Rep. 2019, 9, 1–10. [CrossRef] [PubMed]

14. Pines, M.; Nagler, A. Halofuginone: A novel antifibrotic therapy. Gen. Pharmacol. 1998, 30, 445–450. [CrossRef]

15. McGaha, T.L.; Kodera, T.; Spiera, H.; Stan, A.C.; Pines, M.; Bona, C.A. Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism. Arthritis Rheum. 2002, 46, 2748–2761. [CrossRef] [PubMed]

16. Levi-Schaffer, F.; Nagler, A.; Slavin, S.; Knopov, V.; Pines, M. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: Effect of halofuginone. J. Invest. Dermatol. 1996, 106, 84–88. [CrossRef] [PubMed]

17. Sundrud, M.S.; Koralov, S.B.; Feuerer, M.; Calado, D.P.; Elhed, A.; Rhule-smith, A.; Lefebvre, R.E.; Unutmaz, D.; Waldner, H.; Whitman, M.; et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2010, 324, 1334–1338. [CrossRef] [PubMed]

18. Pines, M.; Halevy, O. Halofuginone and muscular dystrophy. Histol. Histopathol. 2011, 26, 135–146.

19. Nagler, A.; Ohana, M.; Shibolet, O.; Shapira, M.Y.; Alper, R.; Vlodavsky, I.; Pines, M.; Ilan, Y. Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone. Eur. J. Cancer 2004, 40, 1397–1403. [CrossRef]

20. Taras, D.; Blanc, J.-F.; Rullier, A.; Dugot-Senant, N.; Laurendeau, I.; Bièche, I.; Pines, M.; Rosenbaum, J. Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia 2006, 8, 312–318. [CrossRef]

21. Gavish, Z.; Pinthus, J.H.; Barak, V.; Ramon, J.; Nagler, A.; Eshhar, Z.; Pines, M. Growth inhibition of prostate cancer xenografts by halofuginone. Prostate 2002, 51, 73–83. [CrossRef]

22. Gross, D.J.; Reibstein, I.; Weiss, L.; Slavin, S.; Dafni, H.; Neeman, M.; Pines, M.; Nagler, A. Treatment with Halofuginone Results in Marked Growth Inhibition of a von Hippel-Lindau Pheochromocytoma in vivo. Clin. Cancer Res. 2003, 9, 3788–3793. [PubMed]

23. Pinthus, H.J.; Sheffer, Y.; Nagler, A.; Fridman, E.; Mor, Y.; Genina, O.; Pines, M. Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression. J. Urol. 2005, 174, 1527–1531. [CrossRef] [PubMed]

24. Pines, M.; Snyder, D.; Yarkoni, S.; Nagler, A. Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma. Biol. Blood Marrow Transplant. 2003, 9, 417–425. [CrossRef]

25. 25. Onishi, S.; Meguro, S.; Pervin, M.; Kitazawa, H.; Yoto, A.; Ishino, M.; Shimba, Y.; Mochizuki, Y.; Miura, S.; Tokimitsu, I.; et al. Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice. Nutrients 2019, 11, 821. [CrossRef] [PubMed]

26. Faggi, L.; Porrini, V.; Lanzillotta, A.; Benarese, M.; Mota, M.; Tsoukalas, D.; Parrella, E.; Pizzi, M. A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia. Nutrients 2019, 11, 345. [CrossRef] [PubMed]

27. Gorji, N.; Moeini, R.; Memariani, Z. Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer’s disease: A neuropharmacological review of their bioactive constituents. Pharmacol. Res. 2018, 129, 115–127. [CrossRef] [PubMed]

28. Johnson, S.L.; Park, H.Y.; Dasilva, N.A.; Vattem, D.A.; Ma, H.; Seeram, N.P. Levodopa-reduced mucuna pruriens seed extract shows neuroprotective effects against parkinson’s disease in murine microglia and human neuroblastoma cells, Caenorhabditis elegans, and Drosophila melanogaster. Nutrients 2018, 10, 1139. [CrossRef] [PubMed]

29. Altieri, F.; Cairone, F.; Giamogante, F.; Carradori, S.; Locatelli, M.; Chichiarelli, S.; Cesa, S. Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity. Nutrients 2019, 11, 186. [CrossRef]

30. Locri, F.; Cammalleri, M.; Pini, A.; Dal Monte, M.; Rusciano, D.; Bagnoli, P. Further Evidence on Efficacy of Diet Supplementation with Fatty Acids in Ocular Pathologies: Insights from the EAE Model of Optic Neuritis. Nutrients 2018, 10, 1447. [CrossRef]

31. Lu, C.; Wang, Y.; Wang, D.; Zhang, L.; Lv, J.; Jiang, N.; Fan, B.; Liu, X.; Wang, F. Neuroprotective effects of soy isoflavones on scopolamine-induced amnesia in mice. Nutrients 2018, 10, 853. [CrossRef] [PubMed]

32. Miwa, Y.; Hoshino, Y.; Shoda, C.; Jiang, X.; Tsubota, K.; Kurihara, T. Pharmacological HIF inhibition prevents retinal neovascularization with improved visual function in a murine oxygen-induced retinopathy model. Neurochem. Int. 2019, 128, 21–31. [CrossRef] [PubMed]

33. Ahmed, A.; Wang, L.L.; Abdelmaksoud, S.; Aboelgheit, A.; Saeed, S.; Zhang, C.L. Minocycline modulates microglia polarization in ischemia-reperfusion model of retinal degeneration and induces neuroprotection. Sci. Rep. 2017, 7, 1–16. [CrossRef] [PubMed]

34. Schultz, R.; Krug, M.; Precht, M.; Wohl, S.G.; Witte, O.W.; Schmeer, C. Frataxin overexpression in Müller cells protects retinal ganglion cells in a mouse model of ischemia/reperfusion injury in vivo. Sci. Rep. 2018, 8, 1–15. [CrossRef] [PubMed]

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