リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage at the anastomotic site after esophagectomy」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
リケラボ

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage at the anastomotic site after esophagectomy

Kanda, Mitsuro Koike, Masahiko Fukaya, Masahide Miyata, Kazushi Tanaka, Chie Kobayashi, Daisuke Hayashi, Masamichi Yamada, Suguru Nakayama, Goro Murotani, Kenta Fujiwara, Michitaka Nagino, Masato Kodera, Yasuhiro 名古屋大学

2020.02

概要

Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing, β-hydroxy-β-methylbutyrate (HMB) is important for collagen biosynthesis. An open-label prospective intervention trial has been designed to evaluate the treatment effect of an enteral nutrient containing HMB with arginine and glutamine (Abound, Abbott Japan Co., Ltd.) for leakage at the anastomotic site after esophagectomy. Patients in whom leakage at the anastomotic site developed within 14 days after esophagectomy are eligible and Abound (24 g) is administered for 14 days through an enteral feeding tube. The target sample size is 10. The primary endpoint is duration between diagnosis and cure of leakage. Surgical procedure, safety, length of fasting, drainage placement and hospital stay, and nutritional status are determined as secondary endpoints. A historical control consisting of 20 patients who had leakage at the anastomotic site after esophagectomy between 2005 and 2018 at Nagoya University Hospital is compared with enrolled patients.

論文の公開元へ

関連論文

関連論文をもっと見る

参考文献

1) Takeuchi H, Miyata H, Gotoh M, et al. A risk model for esophagectomy using data of 5354 patients

included in a Japanese nationwide web-based database. Ann Surg. 2014;260(2):259–266.

2) Martin LW, Swisher SG, Hofstetter W, et al. Intrathoracic leaks following esophagectomy are no longer

associated with increased mortality. Ann Surg. 2005;242(3):392–399;discussion 399–402.

3) Derogar M, Orsini N, Sadr-Azodi O, et al. Influence of major postoperative complications on health-related

quality of life among long-term survivors of esophageal cancer surgery. J Clin Oncol. 2012;30(14):1615–

1619.

4) Kassis ES, Kosinski AS, Ross P Jr, et al. Predictors of anastomotic leak after esophagectomy: an analysis

of the society of thoracic surgeons general thoracic database. Ann Thorac Surg. 2013;96(6):1919–1926.

5) Goense L, van Rossum PS, Ruurda JP, et al. Radiation to the gastric fundus increases the risk of anastomotic

leakage after esophagectomy. Ann Thorac Surg. 2016;102(6):1798–1804.

6) Kanda M, Tanaka C, Kobayashi D, et al. Proposal of the coagulation score as a predictor for short-term

and long-term outcomes of patients with resectable gastric cancer. Ann Surg Oncol. 2017;24(2):502–509.

7) Hsieh LC, Chien SL, Huang MS, et al. Anti-inflammatory and anticatabolic effects of short-term betahydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive

care unit. Asia Pac J Clin Nutr. 2006;15(4):544–550.

8) Williams JZ, Abumrad N, Barbul A. Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg. 2002;236(3):369–374;discussion 374–365.

9) Kuhls DA, Rathmacher JA, Musngi MD, et al. Beta-hydroxy-beta-methylbutyrate supplementation in critically

ill trauma patients. J Trauma. 2007;62(1):125–131;discussion 131–122.

10) Imai T, Matsuura K, Asada Y, et al. Effect of HMB/Arg/Gln on the prevention of radiation dermatitis in head

and neck cancer patients treated with concurrent chemoradiotherapy. Jpn J Clin Oncol. 2014;44(5):422–427.

11) Okamoto K, Ninomiya I, Hirose A, et al. Effectiveness of the specialized amino acid supplement consisting of CaHMB, L-arginine and L-glutamine (Abound™) for the treatment of anastomotic leakage after

esophagogastrostomy. JSPEN. 2017;32:983–987.

12) Kanda M, Tanaka C, Murotani K, et al. Editors’ Choice Efficacy of enteral nutrients containing beta-hydroxybeta-methylbutyrate, glutamine, and arginine for the patients with anastomotic leakage after gastrectomy:

study protocol of a multicenter phase II clinical trial. Nagoya J Med Sci. 2018;80(3):351–355.

13) Viklund P, Lindblad M, Lu M, et al. Risk factors for complications after esophageal cancer resection: a

prospective population-based study in Sweden. Ann Surg. 2006;243(2):204–211.

14) Karampinis I, Ronellenfitsch U, Mertens C, et al. Indocyanine green tissue angiography affects anastomotic

leakage after esophagectomy. A retrospective, case-control study. Int J Surg. 2017;48:210–214.

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文
を
一発検索！

この論文の関連論文を見る