リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis.」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis.

NAKAGAWA Hiroaki 70799478 0000-0003-3830-765X OTOSHI Ryota ISOMOTO Kohsuke KATANO Takuma BABA Tomohisa KOMATSU Shigeru HAGIWARA Eri NAKANO Yasutaka 00362377 0000-0001-7516-8690 KUWAHIRA Ichiro OGURA Takashi 滋賀医科大学

2020.08.12

概要

Background:
The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radiological features in IPF.
Methods:
The FV curves on PFTs and chest high-resolution computed tomography (HRCT) images of 130 patients with IPF were retrospectively evaluated. The FV curves were divided into four groups based on the presence or absence of the convex and concave patterns: convex/concave, non-convex/concave, convex/non-concave, and non-convex/non-concave. Using a computer-aided system, CT honeycombing area (%HA) and subtracted low attenuation area (%sLAA) were quantitatively measured. To assess the distribution of CT findings, the lung area was divided into upper, lower, central, and peripheral areas. The relationships of FV curve patterns with patient characteristics, spirometry results, and quantitative CT findings were evaluated.
Results:
The patients with convex pattern was identified in 93 (71.5%) and concave pattern in 72 (55.4%). Among the four groups, patients with the convex/non-concave pattern had significantly lower forced vital capacity (FVC) and higher %HA of the upper/peripheral lung area (p = 0.018, and p = 0.005, respectively). The convex/non-concave pattern was a significant predictor of mortality for IPF (hazard ratio, 2.19; p = 0.032).
Conclusions:
Patients with convex/non-concave pattern in FV curve have lower FVC and poorer prognosis with distinct distribution of fibrosis. Hence, FV curve pattern might be a useful predictor of mortality in IPF.

この論文で使われている画像

参考文献

1. Lynch DA, Godwin JD, Safrin S, Starko KM, Hormel P, Brown KK, Raghu G,

King TE Jr, Bradford WZ, Schwartz DA, et al. High-resolution computed

tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J

Respir Crit Care Med. 2005;172(4):488–93.

2. Nishimura K, Kitaichi M, Izumi T, Nagai S, Kanaoka M, Itoh H. Usual interstitial

pneumonia: histologic correlation with high-resolution CT. Radiology. 1992;

182(2):337–42.

3. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and

treatment. International consensus statement. American Thoracic Society

(ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care

Med. 2000;161(2 Pt 1):646–64.

4. Collard HR, King TE Jr, Bartelson BB, Vourlekis JS, Schwarz MI, Brown KK.

Changes in clinical and physiologic variables predict survival in idiopathic

pulmonary fibrosis. Am J Respir Crit Care Med. 2003;168(5):538–42.

5. Jegal Y, Kim DS, Shim TS, Lim CM, Do Lee S, Koh Y, Kim WS, Kim WD, Lee

JS, Travis WD, et al. Physiology is a stronger predictor of survival than

pathology in fibrotic interstitial pneumonia. Am J Respir Crit Care Med.

2005;171(6):639–44.

6. King TE Jr, Safrin S, Starko KM, Brown KK, Noble PW, Raghu G, Schwartz DA.

Analyses of efficacy end points in a controlled trial of interferon-gamma1b

for idiopathic pulmonary fibrosis. Chest. 2005;127(1):171–7.

7. Latsi PI, du Bois RM, Nicholson AG, Colby TV, Bisirtzoglou D, Nikolakopoulou

A, Veeraraghavan S, Hansell DM, Wells AU. Fibrotic idiopathic interstitial

pneumonia: the prognostic value of longitudinal functional trends. Am J

Respir Crit Care Med. 2003;168(5):531–7.

8. Flaherty KR, Mumford JA, Murray S, Kazerooni EA, Gross BH, Colby TV, Travis

WD, Flint A, Toews GB, Lynch JP 3rd, et al. Prognostic implications of

physiologic and radiographic changes in idiopathic interstitial pneumonia.

Am J Respir Crit Care Med. 2003;168(5):543–8.

9. Cottin V, Hansell DM, Sverzellati N, Weycker D, Antoniou KM, Atwood M,

Oster G, Kirchgaessler KU, Collard HR, Wells AU. Effect of emphysema extent

on serial lung function in patients with idiopathic pulmonary fibrosis. Am J

Respir Crit Care Med. 2017;196(9):1162–71.

10. Sharafkhaneh A, Officer TM, Goodnight-White S, Rodarte JR, Boriek AM.

Novel method for measuring effects of gas compression on expiratory flow.

Am J Physiol Regul Integr Comp Physiol. 2004;287(2):R479–84.

11. Ingram RH Jr, Schilder DP. Effect of thoracic gas compression on the flowvolume curve of the forced vital capacity. Am Rev Respir Dis. 1966;94(1):56–63.

12. Piirila PL, Hodgson U, Wuorimaa T, Smith HJ, Sovijarvi AR. Thoracic gas

compression during forced expiration in patients with emphysema,

interstitial lung disease and obesity. BMC Pulmon Medi. 2014;14:34.

13. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV,

Cordier JF, Flaherty KR, Lasky JA, et al. An official ATS/ERS/JRS/ALAT

statement: idiopathic pulmonary fibrosis: evidence-based guidelines for

diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):

788–824.

Nakagawa et al. BMC Pulmonary Medicine

(2020) 20:214

14. Le Souef PN, Hughes DM, Landau LI. Shape of forced expiratory flowvolume curves in infants. Am Rev Respir Dis. 1988;138(3):590–7.

15. Shin HH, Sears MR, Hancox RJ. Prevalence and correlates of a 'knee' pattern

on the maximal expiratory flow-volume loop in young adults. Respirology.

2014;19(7):1052–8.

16. Ley B, Ryerson CJ, Vittinghoff E, Ryu JH, Tomassetti S, Lee JS, Poletti V,

Buccioli M, Elicker BM, Jones KD, et al. A multidimensional index and

staging system for idiopathic pulmonary fibrosis. Ann Intern Med. 2012;

156(10):684–91.

17. Wells AU, Desai SR, Rubens MB, Goh NS, Cramer D, Nicholson AG, Colby TV,

du Bois RM, Hansell DM. Idiopathic pulmonary fibrosis: a composite

physiologic index derived from disease extent observed by computed

tomography. Am J Respir Crit Care Med. 2003;167(7):962–9.

18. Nishimura M. Guideline of respiratory function tests--spirometry, flow-volume

curve, diffusion capacity of the lung. Nihon Kokyuki Gakkai Zasshi. 2004;Suppl:

1–56.

19. Nakagawa H, Nagatani Y, Takahashi M, Ogawa E, Tho NV, Ryujin Y, Nagao T,

Nakano Y. Quantitative CT analysis of honeycombing area in idiopathic

pulmonary fibrosis: correlations with pulmonary function tests. Eur J Radiol.

2016;85(1):125–30.

20. Sakai N, Mishima M, Nishimura K, Itoh H, Kuno K. An automated method to

assess the distribution of low attenuation areas on chest CT scans in

chronic pulmonary emphysema patients. Chest. 1994;106(5):1319–25.

21. Nakano Y, Muro S, Sakai H, Hirai T, Chin K, Tsukino M, Nishimura K, Itoh H,

Pare PD, Hogg JC, et al. Computed tomographic measurements of airway

dimensions and emphysema in smokers. Correlation with lung function. Am

J Respir Crit Care Med. 2000;162(3 Pt 1):1102–8.

22. Sun XW, Gu SY, Li QY, Ren L, Shen JM, Wan HY, Huang SG, Deng WW.

Pulmonary function parameters in high-resolution computed tomography

phenotypes of chronic obstructive pulmonary disease. Am J Med Sci. 2015;

349(3):228–33.

23. Nemoto T, Shibata Y, Osaka D, Abe S, Inoue S, Tokairin Y, Igarashi A,

Yamauchi K, Kimura T, Kishi H, et al. Impact of cigarette smoking on

maximal expiratory flows in a general population: the Takahata study. Intern

Med. 2011;50(21):2547–55.

24. Mead J, Turner JM, Macklem PT, Little JB. Significance of the relationship

between lung recoil and maximum expiratory flow. J Appl Physiol. 1967;

22(1):95–108.

25. Yamashiro T, Moriya H, Matsuoka S, Nagatani Y, Tsubakimoto M, Tsuchiya N,

Murayama S. Asynchrony in respiratory movements between the

pulmonary lobes in patients with COPD: continuous measurement of lung

density by 4-dimensional dynamic-ventilation CT. Int J Chronic Obstruct

Pulmon Dis. 2017;12:2101–9.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in

published maps and institutional affiliations.

Page 10 of 10

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る