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Roles of Energy Production Pathways in Sperm Motility Regulation in Chickens

セティアワン, ランガ SETIAWAN, RANGGA 筑波大学

2020.07.22

概要

Sperm require exogenous signalling and energy substrates to regulate fertilization competence. Despite of extreme importance of glycolysis and oxidative phosphorylation for ATP generation in sperm, a primary mechanism of ATP-generating pathways is species-specific, leaving characteristics of energy management pathways unclear in birds. This study demonstrates how chicken sperm utilize exogenous metabolic substrates to generate ATP production and support sperm motility and fertility.

As described in chapter II, this study characterized expression and localization of several transporter proteins including plasma membrane calcium ATPase isoform 2 and 4 (PMCA2 and PMCA4), and glucose transporter 1 (GLUT1). Detection of these proteins localizing to later spermatids in testis and the midpiece along with sperm flagellum, suggesting these proteins are expressed at late spermiogenesis and play a role in sperm flagellar motility.

As described in chapter III, this study reveals the functional importance of GLUT1 in chicken sperm motility. Of note, female reproductive tract fluids in chicken contain a high concentration of glucose, suggesting the importance of glucose for sperm motility during their traverse in the female reproductive tract. However, the glucose metabolic pathways are poorly characterized in chicken sperm. Using specific antibodies and ligand, localization experiments found that GLUT1 was specifically localized to the midpiece. Sperm motility analysis showed that glucose supported sperm flagellar movements during incubation up to 80 min. However, this was abolished by the addition of a GLUT1 inhibitor, concomitant with a substantial decrease in glucose uptake and ATP production, followed by elevated mitochondrial activity in response to glucose addition. More potent inhibition of ATP production and mitochondrial activity was observed in response to treatment with GLUT inhibitor and uncouplers of oxidative phosphorylation. Because mitochondrial inhibition only reduced a subset of sperm movements, we investigated the localization of the glycolytic pathway and showed GAPDH and hexokinase I at the midpiece and principal piece of the spermatozoa. Together, GLUT1 is specifically localized to the midpiece and plays the main role in glucose uptake to generate ATP production for flagellar motility of chicken sperm.

Chapter IV reveals the primary mechanism of ATP -generating pathways for regulation of sperm function. Sperm provide metabolic energy via glycolysis and oxidative phosphorylation to support sperm motility and penetrability. Although oxidative phosphorylation is considered to be efficient in ATP production, the utilization of ATP for specific sperm function varies among species. Therefore, this study was carried out to reveal the roles of ATP glycolysis and oxidative phosphorylation on sperm motility and penetrability. Sperm motility analysis showed that the addition of either glucose or pyruvate alone, or their combination enhanced sperm movement characteristics. The increasing effects of these metabolic substrates were also found on sperm penetrability, with more potent increase under glucose addition. However, the inhibition of glycolysis and oxidative phosphorylation abolished the increasing effects, with dramatic decrease in the inhibition of oxidative phosphorylation. Similar changes were observed in ATP content. Although the oxidative phosphorylation pathway important in ATP production, is associated with reactive oxygen species (ROS) production, the addition of glucose or pyruvate did not increase ROS level. Instead, the addition of the metabolic substrates appeared to change intracellular pH (pHi) associated with sperm flagellar activity. Since pentose phosphate pathway (PPP) is a semi-intermediate and parallel pathway to glycolysis, we investigated a possession of the pathway in sperm by immunodetection of G6PD, a unique enzyme in PPP, demonstrating its absence in chicken sperm. Our results provide strong evidence that sperm motility and penetrability rely on ATP generated from both glycolysis and oxidative phosphorylation, with a high dependency on glucose.

In conclusion, chicken sperm generate ATP via glycolysis and oxidative phosphorylation by glucose uptake via GLUT1, which results in supporting sperm motility and penetrability. These results reveal new insights into the mechanisms involved in ATP production pathways as well as regulation of sperm fertilization ability and contribute to the development of assisted reproductive technologies (ART) in birds.

参考文献

Aitken RJ, Paterson M, Fisher H, Buckingham DW, Van Duin M. Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function. J Cell Sci 1995;108:2017–2025.

Angulo C, Rauch MC, Droppelmann A, Reyes AM, Slebe JC, Delgado-López F, Guaiquil VH, Vera JC, Concha II. Hexose transporter expression and function in mammalian spermatozoa: Cellular localization and transport of hexoses and vitamin C. J Cell Biochem 1998;71(2):189–203.

Asano A, Selvaraj V, Buttke DE, Nelson JL, Green KM, Evans JE, Travis AJ. Biochemical characterization of membrane fractions in murine sperm: Identification of three distinct sub-types of membrane rafts. J Cell Physiol 2009;218(3):537–548.

Ataur Rahman M, Park SH, Yu IJ. Dog sperm cryopreservation in glucose-fructose or sucrose supplemented glycerol-free tris: Effect of post-thaw incubation time on gene expression related to apoptosis and motility. Cryo-Letters 2018;39(1):45–52.

Austin CR. The capacitation of the mammalian sperm. Nature 1952;170(4321):326.

Bakst MR. Physiology and endocrinology symposium: Role of the oviduct in maintaining sustained fertility in hens. J Anim Sci 2011;89(5):1323–1329.

Bakst MR, Wishart G, Brillard J-P. Oviducal sperm selection, transport, and storage in poultry. Poult Sci Rev 1994;5:117–143.

Ballester J, Fernández-Novell JM, Rutllant J, García-Rocha M, Palomo MJ, Mogas T, Peña A, Rigau T, Guinovart JJ, Rodríguez-Gil JE. Evidence for a functional glycogen metabolism in mature mammalian spermatozoa. Mol Reprod Dev 2000;56(2):207–219.

Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int 2011;2011:1–7.

Bohnensack R, Halangk W. Control of respiration and of motility in ejaculated bull spermatozoa. BBA - Bioenerg 1986;850(1):72–79.

Bolton AE. Presence of the dehydrogenases of the pentose phosphate pathway in boar spermatozoa. Reproduction 1970;21(2):353–354.

Bouillot S, Reboud E, Huber P. Functional consequences of calcium influx promoted by bacterial pore-forming Toxins. Toxins (Basel) 2018;10(10):387.

Brady LJ, Romsos DR, Brady PS, Bergen WG, Leveille GA. The effects of fasting on body composition, glucose turnover, enzymes and metabolites in the chicken. J Nutr 1978;108:648–657.

Breitbart H. Role and regulation of intracellular calcium in acrosomal exocytosis. J Reprod Immunol 2002;53(1–2):151–159.

Brewis IA, Morton IE, Mohammad SN, Browes CE, Moore HD. Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. J Androl 2000;21(2):238–249.

Brini M. Plasma membrane Ca2+-ATPase: From a housekeeping function to a versatile signaling role. Pflugers Arch Eur J Physiol 2009;457(3):657–664.

Bucci D, Isani G, Spinaci M, Tamanini C, Mari G, Zambelli D, Galeati G. Comparative immunolocalization of GLUTs 1, 2, 3 and 5 in boar, stallion and dog spermatozoa. Reprod Domest Anim 2010;45(2):315–322.

Bucci D, Rodriguez-Gil JE, Vallorani C, Spinaci M, Galeati G, Tamanini C. GLUTs and mammalian sperm metabolism. J Androl 2011;32(4):348–355.

Bunch DO, Welch JE, Magyar PL, Eddy EM, O’Brien DA. Glyceraldehyde 3-phosphate dehydrogenase-S protein distribution during mouse spermatogenesis. Biol Reprod 1998;58(3):834–841.

Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO. Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem 1992;267(21):14523–14526.

Burrows WH, Quinn JP. A method of obtaining spermatozoa from the domestic fowl. Poult Sci 1935;14(4):251–254.

Carlson D, Black DL, Howe GR. Oviduct secretion in the cow. J Reprod Fertil 1970;22(3):549–552.

Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ. Production of reactive oxygen species by mitochondria: Central role of complex III. J Biol Chem 2003;278(38):36027–36031.

Cormier N, Bailey JL. A differential mechanism is involved during heparin- and cryopreservation-induced capacitation of bovine spermatozoa. Biol Reprod 2003;69(1):177–185.

Costello S, Michelangeli F, Nash K, Lefievre L, Morris J, Machado-Oliveira G, Barratt C, Kirkman-Brown J, Publicover S. Ca2+-stores in sperm: Their identities and functions. Reproduction 2009;138(3):425–437.

Cross NL. Reorganization of lipid fafts during capacitation of human sperm. Biol Reprod 2004;71(4):1367–1373.

Cross NL. Effect of pH on the development of acrosomal responsiveness of human sperm. Andrologia 2007;39(2):55–59.

Cui Z, Sharma R, Agarwal A. Proteomic analysis of mature and immature ejaculated spermatozoa from fertile men. Asian J Androl 2016;18(5):735–746.

Darszon A, Nishigaki T, Beltran C, Treviño CL. Calcium channels in the development, maturation, and function of spermatozoa. Physiol Rev 2011;91:1305–1355.

Demott RP, Suarez SS. Hyperactivated sperm progress in the mouse oviduct. Biol Reprod 1992;46(5):779–785.

Devaskar SU, Mueckler MM. The mammalian glucose transporters. Pediatr Res 1992;31(1):1–13.

Dias TR, Alves MG, Silva BM, Oliveira PF. Sperm glucose transport and metabolism in diabetic individuals. Mol Cell Endocrinol 2014;396(1):37–45.

Donoghue AM, Wishart GJ. Storage of poultry semen. Anim Reprod Sci 2000;62(1– 3):213–232.

Dragileva E, Rubinstein S, Breitbart H. Intracellular Ca2+-Mg2+-ATPase regulates calcium influx and acrosomal exocytosis in bull and ram spermatozoa. Biol Reprod 1999;61(5):1226–1234.

Dravland E, Meizel S. Stimulation of hamster sperm capacitation and acrosome reaction in vitro by glucose and lactate and inhibition by the glycolytic inhibitor α‐ chlorohydrin. Gamete Res 1981;4(6):515–523.

Druart X. Sperm interaction with the female reproductive tract. Reprod Domest Anim 2012;47:348–352.

Dupuy V, Blesbois E. The effects of age on the composition of uterine fluid of broiler breeder hens and on maintenance of quality of fowl spermatozoa when stored in uterine fluid or in a synthetic medium. Theriogenology 1996;45(6):1221–1234.

van Eck JH, Vertommen M. Biochemical changes in blood and uterine fluid of fowl following experimental EDS’76 virus infection. Vet Q 1984;6(3):127–134.

FAO. World agriculture: towards 2015/2030 an FAO perspective. Earthscan Publ Ltd 2003;158–175.

Farber JL. The role of calcium ions in toxic cell injury. Environ Health Perspect 1990;84:107–111.

Farrel D. Poultry development Review - The role of poultry in human nutrition. FAO 2008;34.

Feiden S, Wolfrum U, Wegener G, Kamp G. Expression and compartmentalisation of the glycolytic enzymes GAPDH and pyruvate kinase in boar spermatogenesis. Reprod Fertil Dev 2008;20(6):713–723.

Ferramosca A, Provenzano SP, Coppola L, Zara V. Mitochondrial respiratory efficiency is positively correlated with human sperm motility. Urology 2012;79(4):809–814.

Fischer B, Bavister BD. Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits. J Reprod Fertil 1993;99(2):673–679.

Ford WCL. Glycolysis and sperm motility: Does a spoonful of sugar help the flagellum go round? Hum Reprod Update 2006;12(3):269–274.

Fraser LR, Quinnn PJ. A glycolytic product is obligatory for initiation of the sperm acrosome reaction and whiplash motility required for fertilization in the mouse. J Reprod Fertil 1981;61(1):25–35.

Froman DP, Feltmann AJ, Rhoads ML, Kirby JD. Sperm mobility: A primary determinant of fertility in the domestic fowl (Gallus domesticus). Biol Reprod 1999;61(2):400– 405.

Fukuhara R, Nishikawa Y. Effects of various substrates on respiration, glycolysis and motility of goat spermatozoa. Nihon Chikusan Gakkaiho 1973;44(5):271–274.

Gallon F, Marchetti C, Jouy N, Marchetti P. The functionality of mitochondria differentiates human spermatozoa with high and low fertilizing capability. Fertil Steril 2006;86(5):1526–1530.

Gardner DK, Leese HJ. Concentrations of nutrients in mouse oviduct fluid and their effects on embryo development and metabolism in vitro. J Reprod Fertil 1990;88(1):361–368.

Goodson SG, Qiu Y, Sutton KA, Xie G, Jia W, O’Brien DA. Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitation. Biol Reprod 2012;87(3):75.

Grigg GW, Rodge AJ. Electron microscopic studies of spermatozoa: I. The morphology of the spermatozoon of the common domestic fowl (Gallus domesticus). Aust J Biol Sci 1949;2(3):271–286.

Haber RS, Weinstein SP, O’Boyle E, Morgello S. Tissue distribution of the human GLUT3 glucose transporter. Endocrinology 1993;132(6):62538–62543.

Hahn KR, Jung HY, Yoo DY, Kim JW, Kim YH, Jo YK, Kim GA, Chung JY, Choi JH, Hwang IK, Jang G, Yoon YS. Immunohistochemical localization of glucose transporter 1 and 3 in the scrotal and abdominal testes of a dog. Lab Anim Res 2017;33(2):114–118.

Harris SE, Gopichandran N, Picton HM, Leese HJ, Orsi NM. Nutrient concentrations in murine follicular fluid and the female reproductive tract. Theriogenology 2005;64(4):992–1006.

Heilig CW, Saunders T, Brosius FC, Moley K, Heilig K, Baggs R, Guoll LR, Conner D. Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc Natl Acad Sci U S A 2003;100(26):15613–15618.

Henchion M, McCarthy M, Resconi VC, Troy D. Meat consumption: Trends and quality matters. Meat Sci 2014;98(3):561–568.

Hugentobler SA, Humpherson PG, Leese HJ, Sreenan JM, Morris DG. Energy substrates in bovine oviduct and uterine fluid and blood plasma during the oestrous cycle. Mol Reprod Dev 2008;75(3):496–503.

Hughes D. Lactate: What does it really tell us? J Physiol 2004;558(1):363–368.

Hyne R V., Edwards KP. Influence of 2-deoxy-D-glucose and energy substrates on guinea-pig sperm capacitation and acrosome reaction. J Reprod Fertil 1985;73(1):59–69.

Hyne R V., Garbers DL. Requirement of serum factors for capacitation and the acrosome reaction of guinea pig spermatozoa in buffered medium below pH 7.81. Biol Reprod 1981;24(2):257–266.

Jane Rogers B, Perreault SD. Importance of glycolysable substrates for in vitro capacitation of human spermatozoa. Biol Reprod 1990;43:1064–1069.

Jane Rogers B, Yanagimachi R. Retardation of guinea pig sperm acrosome reaction by glucose: The possible importance of pyruvate and lactate metabolism in capacitation and the acrosome reaction. Biol Reprod 1975;13(5):568–575.

Jones AR. Antifertility actions of α-chlorohydrin in the male. Aust J Biol Sci 1983;36(4):333–350.

Kamali Sangani A, Masoudi AA, Vaez Torshizi R. Association of mitochondrial function and sperm progressivity in slow- and fast-growing roosters. Poult Sci 2017;96(1):211–219.

Kato M, Makino S, Kimura H, Takao OTA, Furuhashi T, Nagamura Y, Hirano K. In vitro evaluation of acrosomal status and motility in rat epididymal spermatozoa treated with α-chlorohydrin for predicting their fertilizing capacity. J Reprod Dev 2002;48(5):461–468.

Kinet S, Swainson L, Lavanya M, Mongellaz C, Montel-Hagen A, Craveiro M, Manel N, Battini JL, Sitbon M, Taylor N. Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind GLUT-1 on activated CD4+ and CD8+ T cells. Retrovirology 2007;4:31.

Kokk K, Veräjänkorva E, Wu XK, Tapfer H, Põldoja E, Pöllänen P. Immunohistochemical detection of glucose transporters class I subfamily in the mouse, rat and human testis. Medicina (Kaunas) 2004;40(2):156–160.

Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ. Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab 2008;93(8):3199–3207.

Krisfalusi M, Miki K, Magyar PL, O’Brien DA. Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol Reprod 2006;75(2):270– 278.

Kuzlu M, Taskin A. The effect of different extenders on the sperm motility and viability of frozen Turkey semen. Indian J Anim Res 2017;51(2):235–241.

De Lamirande E, Jiang H, Zini A, Kodama H, Gagnon C. Reactive oxygen species and sperm physiology. Rev Reprod 1997;2(1):48–54.

Leahy T, Gadella BM. Sperm surface changes and physiological consequences induced by sperm handling and storage. Reproduction 2011;142(6):759–778.

Leese HJ. The formation and function of oviduct fluid. J Reprod Fertil 1988;82(2):843– 856.

Lishko P V., Mannowetz N. CatSper: a unique calcium channel of the sperm flagellum. Curr Opin Physiol 2018;2:109–113.

Luconi M, Krausz C, Forti G, Baldi E. Extracellular calcium negatively modulates tyrosine phosphorylation and tyrosine kinase activity during capacitation of human spermatozoa. Biol Reprod 1996;55(1):207–216.

Luna C, Serrano E, Domingo J, Casao A, Pérez-Pé R, Cebrián-Pérez JA, Muiño-Blanco T. Expression, cellular localization, and involvement of the pentose phosphate pathway enzymes in the regulation of ram sperm capacitation. Theriogenology 2016;86(3):704–714.

Ma X, Jin M, Cai Y, Xia H, Long K, Liu J, Yu Q, Yuan J. Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol 2011;18(11):1474–1481.

Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 2003;115(4):449–459.

Mann T. Studies on the metabolism of semen; fructose as a normal constituent of seminal plasma; site of formation and function of fructose in semen. Biochem J 1946;44:97.

Mannowetz N, Wandernoth PM, Wennemuth G. Glucose is a pH-dependent motor for sperm beat frequency during early activation. PLoS One 2012;7(7):1–15.

Marchetti C. Study of mitochondrial membrane potential, reactive oxygen species, DNA fragmentation and cell viability by flow cytometry in human sperm. Hum Reprod 2002;17(5):1257–1265.

Marquez B, Suarez SS. Bovine sperm hyperactivation is promoted by alkaline-stimulated Ca2+ influx. Biol Reprod 2007;76(4):660–665.

McLean DJ, Jones LG, Froman DP. Reduced glucose transport in sperm from roosters (Gallus domesticus) with heritable subfertility. Biol Reprod 1997;57(4):791–795.

Miki K. Energy metabolism and sperm function. Soc Reprod Fertil Suppl 2007;65:305– 325.

Miki K, Qu W, Goulding EH, Willis WD, Bunch DO, Strader LF, Perreault SD, Eddy EM, O’Brien DA. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Proc Natl Acad Sci U S A 2004;101(47):16501–16506.

Miraglia E, Lussiana C, Viarisio D, Racca C, Cipriani A, Gazzano E, Bosia A, Revelli A, Ghigo D. The pentose phosphate pathway plays an essential role in supporting human sperm capacitation. Fertil Steril 2010;93(7):2437–2440.

Mudalal S, Babini E, Cavani C, Petracci M. Quantity and functionality of protein fractions in chicken breast fillets affected by white striping. Poult Sci 2014;93(8):2108–2116. Mujica A, Moreno-Rodriguez R, Naciff J, Neri L, Tash JS. Glucose regulation of guinea-

pig sperm motility. Reproduction 1991;92(1):75–87.

Mukai C, Okuno M. Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement. Biol Reprod 2004;71(2):540– 547.

Nakamura N, Shibata H, O’Brien DA, Mori C, Eddy EM. Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm. Mol Reprod Dev 2008;75(4):632–640.

Nevo AC. Dependence of sperm motility and respiration on oxygen concentration. J Reprod Fertil 1965;9:103–107.

Ng KYB, Mingels R, Morgan H, Macklon N, Cheong Y. In vivo oxygen, temperature and pH dynamics in the female reproductive tract and their importance in human conception: A systematic review. Hum Reprod Update 2018;24(1):15–34.

Nguyen TMD, Alves S, Grasseau I, Métayer-Coustard S, Praud C, Froment P, Blesbois E. Central role of 5-AMP-activated protein kinase in chicken sperm functions. Biol Reprod 2014;91(5):121.

Nichol R, Hunter RHF, Gardner DK, Leese HJ, Cooke GM. Concentrations of energy substrates in oviductal fluid and blood plasma of pigs during the peri-ovulatory period. J Reprod Fertil 1992;96(2):699–707.

O’Donnell L. Mechanisms of spermiogenesis and spermiation and how they are disturbed. Spermatogenesis 2014;4(2):e979623.

O’Flaherty C, de Lamirande E, Gagnon C. Positive role of reactive oxygen species in mammalian sperm capacitation: triggering and modulation of phosphorylation events. Free Radic Biol Med 2006;41(4):528–540.

Okunade GW, Miller ML, Pyne GJ, Sutliff RL, O’Connor KT, Neumann JC, Andringa A, Miller DA, Prasad V, Doetschman T, Paul RJ, Shull GE. Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem 2004;279(32):33742–33750.

Parrish JJ, Susko-Parrish JL, First NL. Capacitation of bovine sperm by heparin: Inhibitory effect of glucose and role of intracellular pH. Biol Reprod 1989;41(4):683–699.

Du Plessis SS, Agarwal A, Halabi J, Tvrda E. Contemporary evidence on the physiological role of reactive oxygen species in human sperm function. J Assist Reprod Genet 2015;32(4):509–520.

Ponglowhapan S, Essén-Gustavsson B, Linde Forsberg C. Influence of glucose and fructose in the extender during long-term storage of chilled canine semen. Theriogenology 2004;62:1498–1517.

Post H, Schwarz A, Brandenburger T, Aumüller G, Wilhelm B. Arrangement of PMCA4 in bovine sperm membrane fractions. Int J Androl 2010;33(6):775–783.

Pym R. Poultry genetics and breeding in developing countries. Food Agric Organ United Nations Poult Dev Rev 2008;1–3.

Qiu JH, Li YW, Xie HL, Li Q, Dong HB, Sun MJ, Gao WQ, Tan JH. Effects of glucose metabolism pathways on sperm motility and oxidative status during long-term liquid storage of goat semen. Theriogenology 2016;86(3):839–849.

Reinhardt TA, Lippolis JD, Shull GE, Horst RL. Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem 2004;279(41):42369–42373.

Ren D, Xia J. Calcium signaling through CatSper channels in mammalian fertilization. Physiol 2010;25(3):165–175.

Rigau T, Farré M, Ballester J, Mogas T, Pea A, Rodríguez-Gil JE. Effects of glucose and fructose on motility patterns of dog spermatozoa from fresh ejaculates. Theriogenology 2001;56(5):801–815.

Robertson L, Bailey JL, Buhr MM. Effects of cold shock and phospholipase A2 on intact boar spermatozoa and sperm head plasma membranes. Mol Reprod Dev 1990;26(2):143–149.

Ruiz-Pesini E, Diez C, Lapena AC, Perez-Martos A, Montoya J, Alvarez E, Arenas J, Lopez-Perez MJ. Correlation of sperm motility with mitochondrial enzymatic activities. Clin Chem 1998;44(8 part 1):1616–1620.

Sans P, Combris P. World meat consumption patterns: An overview of the last fifty years (1961-2011). Meat Sci 2015;109:106–111.

Saxena VK, Kolluri G. Selection methods in poultry breeding: From genetics to genomics. Appl Genet Genomics Poult Sci 2018;19–32.

Schroeder TC, Barkley AP, Schroeder KC. Income growth and international meat consumption. J Int Food Agribus Mark 1996;7(3):15–30.

Schuh K, Cartwright EJ, Jankevics E, Bundschu K, Liebermann J, Williams JC, Armesilla AL, Emerson M, Oceandy D, Knobeloch KP, Neyses L. Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. J Biol Chem 2004;279(27):28220–28226.

Schurmann A, Koling S, Jacobs S, Saftig P, Krau S, Wennemuth G, Kluge R, Joost H-G. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Mol Cell Biol 2002;22(8):2761– 2768.

Scott TW, White IG, Annison EF. Glucose and acetate metabolism by ram, bull, dog and fowl spermatozoa. Biochem J 1962;83:398–404.

Sexton TJ. Oxidative and glycolytic activity of chicken and turkey spermatozoa. Comp Biochem Physiol -- Part B Biochem 1974;48(B):59–65.

Shadan S, James PS, Howes EA, Jones R. Cholesterol efflux alters lipid raft stability and distribution during capacitation of boar spermatozoa. Biol Reprod 2004;71(1):253– 265.

Shen HM, Ong CN. Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility. Free Radic Biol Med 2000;28(4):529–536.

Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ. The facilitative glucose transporter GLUT3: 20 Years of distinction. Am J Physiol - Endocrinol Metab 2008;265(2):E242-253.

Singh RP, Sastry KVH, Pandey NK, Shit N, Agrawal R, Singh KB, Mohan J, Saxena VK, Moudgal RP. Characterization of lactate dehydrogenase enzyme in seminal plasma of Japanese quail (Coturnix coturnix japonica). Theriogenology 2011;75:555–562.

Sprando RL, Russell LD. Comparative study of cytoplasmic elimination in spermatids of selected mammalian species. Am J Anat 1987;178(1):72–80.

Stauss CR, Votta TJ, Suarez SS. Sperm motility hyperactivation facilitates penetration of the hamster zona pellucida. Biol Reprod 1995;53(6):1280–1285.

Storey BT. Mammalian sperm metabolism: Oxygen and sugar, friend and foe. Int J Dev Biol 2008;52(5–6):427–437.

Strehler EE, Zacharias DA. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 2001;81(1):21–50.

Sung TK, Moley KH. The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and sperm. Reprod Sci 2007;14(5):445–455.

Thaler CD, Thomas M, Ramalie JR. Reorganization of mouse sperm lipid rafts by capacitation. Mol Reprod Dev 2006;73(12):1541–1549.

Thurston RJ, Hess RA. Ultrastructure of spermatozoa from domesticated birds: comparative study of turkey, chicken and guinea fowl. Scanning Microsc 1987;1(4):1829–1838.

Van Tilburg MF, Rodrigues MAM, Moreira RA, Moreno FB, Monteiro-Moreira ACO, Cândido MJD, Moura AA. Membrane-associated proteins of ejaculated sperm from Morada Nova rams. Theriogenology 2013;79(9):1247–1261.

Tourmente M, Villar-Moya P, Rial E, Roldan ERS. Differences in ATP generation via glycolysis and oxidative phosphorylation and relationships with sperm motility in mouse species. J Biol Chem 2015;290(33):20613–20626.

Travis AJ, Foster JA, Rosenbaum NA, Visconti PE, Gerton GL, Kopf GS, Moss SB.

Targeting of a germ cell-specific type 1 hexokinase lacking a porin-binding domain to the mitochondria as well as to the head and fibrous sheath of murine spermatozoa. Mol Biol Cell 1998;9(2):263–276.

Travis AJ, Jorgez CJ, Merdiushev T, Jones BH, Dess DM, Diaz-Cueto L, Storey BT, Kopf GS, Moss SB. Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolic pathways in murine spermatozoa. J Biol Chem 2001;276(10):7630–7636.

Urner F, Sakkas D. A possible role for the pentose phosphate pathway of spermatozoa in gamete fusion in the mouse. Biol Reprod 1999;60(3):733–739.

Urner F, Sakkas D. Involvement of the pentose phosphate pathway and redox regulation in fertilization in the mouse. Mol Reprod Dev 2005;70(4):494–503.

Ushiyama A, Priyadarshana C, Setiawan R, Miyazaki H, Ishikawa N, Tajima A, Asano A. Membrane raft-mediated regulation of glucose signaling pathway leading to acrosome reaction in chicken sperm. Biol Reprod 2019;100(6):1482–1491.

Ushiyama A, Tajima A, Ishikawa N, Asano A. Characterization of the functions and proteomes associated with membrane rafts in chicken sperm. PLoS One 2017;12(11):e0186482.

Visconti PE, Bailey JL, Moore GD, Pan D, Olds-Clarke P, Kopf GS. Capacitation of mouse spermatozoa: I. Correlation between the capacitation state and protein tyrosine phosphorylation. Development 1995;121(4):1129–1137.

Vogl AW, Young JS, Du M. New insights into roles of tubulobulbar complexes in sperm release and turnover of blood-testis barrier. Int Rev Cell Mol Biol 2013;303:319–355.

Wagner H, Cheng JW, Ko EY. Role of reactive oxygen species in male infertility: An updated review of literature. Arab J Urol 2018;16(1):35–43.

Walker P, Rhubart-Berg P, McKenzie S, Kelling K, Lawrence RS. Public health implications of meat production and consumption. Public Health Nutr 2005;8(4):348–356.

Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. Development of a novel class of glucose transporter inhibitors. J Med Chem 2012;55(8):3827–3836.

Welch JE, Schatte EC, O’Brien DA, Eddy EM. Expression of a glyceraldehyde 3- phosphate dehydrogenase gene specific to mouse spermatogenic cells. Biol Reprod 1992;46(5):869–878.

Wennemuth G, Babcock DF, Hille B. Calcium clearance mechanisms of mouse sperm. J Gen Physiol 2003;122(1):115–128.

Westhoff D, Kamp G. Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa. J Cell Sci 1997;110(15):1821–1829.

Williams AC, Ford WCL. The role of glucose in supporting motility and capacitation in human spermatozoa. J Androl 2001;22(4):680–695.

Wishart GJ. Maintenance of ATP concentrations in and of fertilizing ability of fowl and turkey spermatozoa in vitro. J Reprod Fertil 1982;66(2):457–462.

Wishart GJ, Palmer FH. Correlation of the fertilising ability of semen from individual male fowls with sperm motility and ATP content. Br Poult Sci 1986;27(1):97–102.

Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, Schimmer AD. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther 2008;7(11):3546–3555.

Xi MD, Li P, Du H, Qiao XM, Liu ZG, Wei QW. Disaccharide combinations and the expression of enolase3 and plasma membrane Ca2+ ATPase isoform in sturgeon sperm cryopreservation. Reprod Domest Anim 2018;53(2):472–483.

Yoshida K, Shiba K, Sakamoto A, Ikenaga J, Matsunaga S, Inaba K, Yoshida M. Ca2+ efflux via plasma membrane Ca2+-ATPase mediates chemotaxis in ascidian sperm. Sci Rep 2018;8(1):16622.

Young SAM, Miyata H, Satouh Y, Aitken RJ, Baker MA, Ikawa M. CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. J Cell Sci 2016;129(23):4379–4387.

Yumura Y, Iwasaki A, Saito K, Ogawa T, Hirokawa M. Effect of reactive oxygen species in semen on the pregnancy of infertile couples. Int J Urol 2009;16(2):202–207.

Zhang J, Xiao P, Zhang X. Phosphatidylserine externalization in caveolae inhibits Ca2+ efflux through plasma membrane Ca2+-ATPase in ECV304. Cell Calcium 2009;45(2):177–184.

Zhao Y, Buhr MM. Cryopreservation extenders affect calcium flux in bovine spermatozoa during a temperature challenge. J Androl 1995;16(3):278–285.

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