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Propofol elicits apoptosis and attenuates cell growth in esophageal cancer cell lines

Zhou, Rui Konishi, Yuko Zhang, Ailing Nishiwaki, Kimitoshi 名古屋大学

2023.08

概要

Propofol is a lipophilic intravenous anesthetic agent commonly used in surgical operation
and intensive care owing to its rapid and controllable sedative effect.1,2 Propofol creates diverse
impacts on cell biological functions, including positive modulation of g-aminobutyric acid A
(GABAA) receptor.3 Propofol also binds to cellular and mitochondrial membranes, disrupts their
Received: July 13, 2022; accepted: October 24, 2022
Corresponding Author: Yuko Konishi, PhD
Endowed Division of Perioperative Management, Nagoya University Graduate School of Medicine,
65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Tel: +81-52-741-2111 ext. ...

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参考文献

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Propofol and esophageal cancer cell line

SUPPLEMENTARY MATERIALS

Supplementary Fig. 1 Proliferation of KYSE30 cells was suppressed by 0.5% (v/v) DMSO

but not by 0.5% (v/v) ethanol

Supplementary Fig. 1a: Experimental design to assess the effects of 0.5% (v/v) diluents (ethanol and DMSO)

on the proliferation of esophageal cancer cell lines KYSE30 and KYSE960.

Supplementary Fig. 1b: Cell numbers counted in the assay delineated in (a) (mean ± SD; n = 5). DMSO

indicates dimethyl sulfoxide. *p < 0.05.

References End

Nagoya J. Med. Sci. 85. 579–591, 2023

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