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Acknowledgements

We thank M. Hibi for providing plasmids and helpful discussions and

A. Kawahara, T Masuda, and Ishitani lab members for their helpful discussions, technical support, and fish maintenance. This research was

supported by the Takeda Science Foundation (T.I.), Mitsubishi Foundation (T.I.), Daiichi Sankyo Foundation (T.I.), Uehara Memorial Foundation

(T.I.), Mochida Memorial Foundation (T.I.), Ono Medical Foundation (T.I.),

SECOM Science and Technology Foundation (T.I.), KOSE Cosmetology

Foundation (T.I.), Naito Foundation (T.I.), JST FOREST (M.O.), Grant-in-Aid

for Transformative Research Areas(A) (21H05287) (T.I.), Scientific

Research (B) (22H02820) (T.I.), Challenging Exploratory Research

(23K18242) (T.I.)., Transformative Research Areas(B) (20H05791) (M.O.),

and JSPS Fellows (21J14254) (J.Z.).

Author contributions

Conception and design: J.Z. and T.I.; Investigation: J.Z., S.A., S.O., S.I.,

and M.O.; Writing and review: J.Z. and T.I.; Writing contribution and

review: S.A., S.O., S.I., and M.O.

Competing interests

The authors declare no competing interests.

Additional information

Supplementary information The online version contains

supplementary material available at

https://doi.org/10.1038/s41467-023-42963-3.

Correspondence and requests for materials should be addressed to

Tohru Ishitani.

Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work. A

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