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Acknowledgements
This research was supported by AMED under Grant Number JP21bm0104001 and a grant from the Fujiwara
Memorial Incorporated Foundation. We thank Dr. C. Okubo, Dr. H. Kagawa, Dr. T. Yamakawa, Dr. K. Okita,
and Dr. K. Takahashi for scientific discussions; Dr. A. Ohta and Dr. Y. Nishi for technical assistance with the
ArrayScan analysis; and Dr. P. Karagiannis for reading the manuscript.
Author contributions
C.A. and M.N. wrote the main manuscript text. C.A. mainly prepared all figures (supported by C.S., Y.C., T.I.,
and M.N.). Proteome analysis was done by Y.K. and M.I.. All authors reviewed the manuscript.
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Competing interests M.I. is a scientific adviser (without salary) of xFOREST therapeutics. Other authors do not provide a competing
interest statement.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.org/
10.1038/s41598-021-03260-5.
Correspondence and requests for materials should be addressed to M.N.
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