Studies on the Physiological Functions of Kaki Fruit Extracts against Oxidative Stress in Skeletal Muscle

Abubakar, A. R., & Haque, M. (2020). Preparation of medicinal plants: basic extraction and fractionation procedures for experimental purposes. J Pharm Bioall Sci, 12, 1–10. https://doi.org/10.4103/jpbs.JPBS

Akter, M. S., Ahmed, M., & Eun, J. B. (2010). Solvent effects on antioxidant properties of persimmon (Diospyros kaki L. cv. Daebong) seeds. Int J Food Sci Technol, 45, 2258–2264. https://doi.org/10.1111/j.1365-2621.2010.02400.x

Alfarafisa, N. M., Kitaguchi, K., & Yabe, T. (2020). The Aging of Skeletal Muscle and Potential Therapeutic Effects of Extracts from Edible and Inedible Plants. Reviews in Agricultural Science, 70–88.

Allen, S. C. (2017). Systemic inflammation in the genesis of frailty and sarcopenia: an overview of the preventative and therapeutic role of exercise and the potential for drug treatments. Geriatrics, 2. https://doi.org/10.3390/geriatrics2010006

Anwar, H., Hussain, G., & Mustafa, I. (2018). Antioxidants from Natural Sources. In Antioxidants in Foods and Its Applications (pp. 3–28). https://doi.org/10.5772/intechopen.75961

Araujo, C. R. R., Silva, T. de M., Lopes, M., Villela, P., Alcantara, A. F. de C., & Dessimoni-Pinto, N. A. V. (2013). Total antioxidant capacity, total phenolic content and mineral elements in the fruit peel of Myrciaria cauliflora Capacidade antioxidante total, conteúdo fenólico total e elementos minerais nas cascas do fruto de Myrciaria cauliflora. Food Technology, 16, 301–309. https://doi.org/10.1590/S1981-67232013005000036

Awortwe, C., Fasinu, P. S., & Rosenkranz, B. (2014). Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challenges. J Pharm Pharm Sci, 17(1), 1–19. https://doi.org/10.18433/j30k63

Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016). Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality? J Appl Physiol, 121, 1047–1052. https://doi.org/10.1152/japplphysiol.00321.2016

Beccafico, S., Puglielli, C., Pietrangelo, T., Bellomo, R., Fanò, G., & Fulle, S. (2007). Age-dependent effects on functional aspects in human satellite cells. Ann. N. Y. Acad. Sci, 1100, 345–352. https://doi.org/10.1196/annals.1395.037

Bei, W., Peng, W., Ma, Y., & Xu, A. (2005). Flavonoids from the leaves of Diospyros kaki reduce hydrogen peroxide-induced injury of NG108-15 cells. Life Sciences, 76, 1975–1988. https://doi.org/10.1016/j.lfs.2004.09.031

Boeing, J. S., Barizão, É. O., e Silva, B. C., Montanher, P. F., de Cinque Almeida, V., & Visentainer, J. V. (2014). Evaluation of solvent effect on the extraction of phenolic compounds and antioxidant capacities from the berries: application of principal component analysis. Chem Cent J, 8. https://doi.org/10.1186/s13065-014-0048-1

Bogdanowicz, D. R., & Lu, H. H. (2013). Studying cell-cell communication in co-culture. Biotechnol J., 8, 395–396. https://doi.org/10.1038/jid.2014.371

Bouzid, M. A., Filaire, E., McCall, A., & Fabre, C. (2015). Radical oxygen species, exercise and aging: an update. Sports. Med., 45, 1245–1261. https://doi.org/10.1007/s40279-015-0348-1

Brioche, T., & Lemoine-Morel, S. (2016). Oxidative stress, sarcopenia, antioxidant strategies and exercise: molecular aspects. Current Pharmaceutical Design, 22(18), 2664–2678. https://doi.org/10.2174/1381612822666160219120531

Buckinx, F., Rolland, Y., Reginster, J. Y., Ricour, C., Petermans, J., & Bruyère, O. (2015). Burden of frailty in the elderly population: Perspectives for a public health challenge. Archives of Public Health, 73(1), 1–7. https://doi.org/10.1186/s13690-015-0068-x

Butt, M. S., Sultan, T., Aziz, M., Naz, A., Ahmed, W., Kumar, N., & Imran, M. (2015). Persimmon (Diospyros kaki) fruit: hidden phytochemicals and health claims. EXCLI Journal, 14, 542–561.

Cai, A., Hardt, M., Schneider, P., Schmid, R., Lange, C., Dippold, D., Schubert, D. W., Boos, A. M., Weigand, A., Arkudas, A., Horch, R. E., & Beier, J. P. (2018). Myogenic differentiation of primary myoblasts and mesenchymal stromal cells under serum-free conditions on PCL-collagen I-nanoscaffolds. BMC Biotechnology, 18. https://doi.org/10.1186/s12896-018-0482-6

Calvani, R., Joseph, A.-M., Adhihetty, P. J., Miccheli, A., Bossola, M., Leeuwenburgh, C., & Bernabei, R. (2013). Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biol Chem, 394, 393–414.

Chamchoy, K., Pakotiprapha, D., Pumirat, P., Leartsakulpanich, U., & Boonyuen, U. (2019). Application of WST-8 based colorimetric NAD(P)H detection for quantitative dehydrogenase assays. BMC Biochem, 20. https://doi.org/10.1186/s12858-019-0108-1

Chandrasekhar, J., Madhusudhan, M. C., & Raghavarao, K. S. M. S. (2012). Extraction of anthocyanins from red cabbage and purification using adsorption. Food and Bioproducts Processing, 90, 615–623. https://doi.org/10.1016/j.fbp.2012.07.004

Chen, X. N., Fan, J. F., Yue, X., Wu, X. R., & Li, L. T. (2008). Radical scavenging activity and phenolic compounds in persimmon (Diospyros kaki L. cv. Mopan). J. Food Sci., 73. https://doi.org/10.1111/j.1750-3841.2007.00587.x

Choe, J. H., Kim, C. J., Kim, H. Y., Kim, Y. J., & Yeo, E. J. (2014). Antioxidant activity and phenolic content of persimmon peel extracted with different levels of ethanol. Int. J. Food Prop., 17, 1779–1790. https://doi.org/10.1080/10942912.2012.731460

Číž, M., Čížová, H., Denev, P., Kratchanova, M., Slavov, A., & Lojek, A. (2010). Different methods for control and comparison of the antioxidant properties of vegetables. Food Control, 21, 518–523. https://doi.org/10.1016/j.foodcont.2009.07.017

Clavel, S., Coldefy, A. S., Kurkdjian, E., Salles, J., Margaritis, I., & Derijard, B. (2006). Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle. Mech. Ageing Dev., 127, 794–801. https://doi.org/10.1016/j.mad.2006.07.005

Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013). Frailty in elderly people. The Lancet, 381(9868), 752–762. https://doi.org/10.1016/S0140-6736(12)62167-9

Coen, P. M., Jubrias, S. A., Distefano, G., Amati, F., Mackey, D. C., Glynn, N. W., Manini, T. M., Wohlgemuth, S. E., Leeuwenburgh, C., Cummings, S. R., Newman, A. B., Ferrucci, L., Toledo, F. G. S., Shankland, E., Conley, K. E., & Goodpaster, B. H. (2013). Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J. Gerontol. A Biol. Sci. Med. Sci., 68, 447–455. https://doi.org/10.1093/gerona/gls196

Cozzi, R., Ricordy, R., Aglitti, T., Gatta, V., Perticone, P., & De Salvia, R. (1997). Ascorbic acid and β-carotene as modulators of oxidative damage. Carcinogenesis, 18(1), 223–228. https://doi.org/10.1093/carcin/18.1.223

Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J. P., Rolland, Y., Schneider, S. M., Topinková, E., Vandewoude, M., & Zamboni, M. (2010). Sarcopenia: european consensus on definition and diagnosis. Age Ageing, 39, 412–423. https://doi.org/10.1093/ageing/afq034

Dalvi, L. T., Moreira, D. C., Alonso, A., de Avellar, I. G. J., & Hermes-Lima, M. (2018). Antioxidant activity and mechanism of commercial Rama Forte persimmon fruits (Diospyros kaki). PeerJ, 2018(7), 1–22. https://doi.org/10.7717/peerj.5223

Das, K., Tiwari, R. K. S., & Shrivastava, D. K. (2010). Techniques for evaluation of medicinal plant products as antimicrobial agent: current methods and future trends. J. Med. Plant. Res., 4, 104–111. https://doi.org/10.5897/JMPR09.030

Dejong, C. H. C., Busquets, S., Moses, A. G. W., Schrauwen, P., Ross, J. A., Argiles, J. M., & Fearon, K. C. H. (2005). Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia. Oncol. Rep., 14, 257–263. https://doi.org/10.3892/or.14.1.257

Denev, P., & Yordanov, A. (2013). Total polyphenol, proanthocyanidin and flavonoid content, carbohydrate composition and antioxidant activity of persimmon (Diospyros kaki L.) fruit in relation to cultivar and maturity stage. Bulg. J. Agric. Sci., 19, 981–988.

Dhanani, T., Shah, S., Gajbhiye, N. A., & Kumar, S. (2017). Effect of extraction methods on yield, phytochemical constituents and antioxidant activity of Withania somnifera. Arab J. Chem., 10, S1193–S1199. https://doi.org/10.1016/j.arabjc.2013.02.015

Dirks, A. J., & Leeuwenburgh, C. (2006). Tumor necrosis factor α signaling in skeletal muscle: effects of age and caloric restriction. J. Nutr. Biochem., 17, 501–508. https://doi.org/10.1016/j.jnutbio.2005.11.002

Ebisui, C., Tsujinaka, T., Morimoto, T., Kan, K., Iijima, S., Yano, M., Kominami, E., Tanaka, K., & Monden, M. (1995). Interleukin-6 induces proteolysis by activating intracellular proteases (cathepsins B and L, proteasome) in C2C12 myotubes. Clin. Sci., 89, 431–439. https://doi.org/10.1042/cs0890431

Fang, Y. Z., Yang, S., & Wu, G. (2002). Free radicals, antioxidants, and nutrition. Nutrition, 18, 872–879. https://doi.org/10.1016/S0899-9007(02)00916-4

Febbraio, M. A., Hiscock, N., Sacchetti, M., Fischer, C. P., & Pedersen, B. K. (2004). Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes, 53, 1643–1648. https://doi.org/10.2337/diabetes.53.7.1643

Fedarko, N. S. (2011). The biology of aging and frailty. Clin. Geriatr. Med., 27, 27–37. https://doi.org/10.1038/jid.2014.371

Ferraretto, A., Bottani, M., De Luca, P., Cornaghi, L., Arnaboldi, F., Maggioni, M., Fiorilli, A., & Donetti, E. (2018). Morphofunctional properties of a differentiated Caco2/HT-29 co-culture as an in vitro model of human intestinal epithelium. Biosci. Rep., 38, 1–16. https://doi.org/10.1042/BSR20171497

Ferreira, R., Vitorino, R., Alves, R. M. P., Appell, H. J., Powers, S. K., Duarte, J. A., & Amado, F. (2010). Subsarcolemmal and intermyofibrillar mitochondria proteome differences disclose functional specializations in skeletal muscle. Proteomics, 10, 3142–3154. https://doi.org/10.1002/pmic.201000173

Forouzanfar, F., Torabi, S., Askari, V. R., Asadpour, E., & Sadeghnia, H. R. (2016). Protective effect of Diospyros kaki against glucose-oxygen-serum deprivation- induced PC12 cells injury. Adv Pharmacol Sci. https://doi.org/10.1155/2016/3073078

Franckhauser, S., Elias, I., Rotter Sopasakis, V., Ferré, T., Nagaev, I., Andersson, C. X., Agudo, J., Ruberte, J., Bosch, F., & Smith, U. (2008). Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice. Diabetologia, 51, 1306–1316. https://doi.org/10.1007/s00125-008-0998-8

Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., & McBurnie, M. A. (2001). Frailty in older adults: Evidence for a phenotype. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 56(3), 146–157. https://doi.org/10.1093/gerona/56.3.m146

Fulle, S., Protasi, F., Di Tano, G., Pietrangelo, T., Beltramin, A., Boncompagni, S., Vecchiet, L., & Fanò, G. (2004). The contribution of reactive oxygen species to sarcopenia and muscle ageing. Exp. Gerontol., 39, 17–24. https://doi.org/10.1016/j.exger.2003.09.012

Gao, H., Cheng, N., Zhou, J., Wang, B., Deng, J., & Cao, W. (2014). Antioxidant activities and phenolic compounds of date plum persimmon (Diospyros lotus L.) fruits. J. Food Sci. Technol., 51, 950–956. https://doi.org/10.1007/s13197-011- 0591-x

George, A. P., & Redpath, S. (2008). Health and medicinal benefits of persimmon fruit: a review. Adv. Hort. Sci., 22, 244–249. https://doi.org/10.1400/100649

Giordani, E., Doumett, S., Nin, S., & Del Bubba, M. (2011). Selected primary and secondary metabolites in fresh persimmon (Diospyros kaki Thunb.): a review of analytical methods and current knowledge of fruit composition and health benefits. Food Res. Int., 44, 1752–1767. https://doi.org/10.1016/j.foodres.2011.01.036

Goers, L., Freemont, P., & Polizzi, K. M. (2014). Co-culture systems and technologies: taking synthetic biology to the next level. J. R. Soc. Interface, 11.

Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Cezar, M. D. M., Lima, A. R. R., Okoshi, K., & Okoshi, M. P. (2017). Skeletal muscle aging: influence of oxidative stress and physical exercise. Oncotarget, 8, 20428–20440. https://doi.org/10.18632/oncotarget.14670

Gonzales, G. B., Van Camp, J., Vissenaekens, H., Raes, K., Smagghe, G., & Grootaert, C. (2015). Review on the use of cell cultures to study metabolism, transport, and accumulation of flavonoids: from mono-cultures to co-culture systems. Compr. Rev. Food Sci. Food Saf., 14, 741–754. https://doi.org/10.1111/1541-4337.12158

Goutzourelas, N., Stagos, D., Spanidis, Y., Liosi, M., Apostolou, A., Priftis, A., Haroutounian, S., Spandidos, D. A., Tsatsakis, A. M., & Kouretas, D. (2015). Polyphenolic composition of grape stem extracts affects antioxidant activity in endothelial and muscle cells. Molecular Medicine Reports, 12(4), 5846–5856. https://doi.org/10.3892/mmr.2015.4216

Grasset, E., Pinto, M., Dussaulx, E., Zweibaum, A., & Desjeux, J. F. (1984). Ephitelial properties of human colonic carcinoma cell line Caco-2: electrical parameters. Am. J. Physiol., 247, C260–C267. https://doi.org/10.1152/ajpcell.1985.248.5.c410

Grune, T., Merker, K., Sandig, G., & Davies, K. J. A. (2003). Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem. Biophys. Res. Commun., 305, 709–718. https://doi.org/10.1016/S0006-291X(03)00809-X

Gulcin, İ. (2020). Antioxidants and antioxidant methods: an updated overview. Archives of Toxicology, 94(3), 651–715. https://doi.org/10.1007/s00204-020-02689-3

Han, Y. C., Wu, J. Y., & Wang, C. K. (2019). Modulatory effects of miracle fruit ethanolic extracts on glucose uptake through the insulin signaling pathway in C2C12 mouse myotubes cells. Food Science and Nutrition, 7(3), 1035–1042. https://doi.org/10.1002/fsn3.935

Harman, D. (1956). Aging: a theory on free radical radiation chemistry. J. Gerontol., 11, 298–300.

Heras, M.-L. R., Pinazo, A., Heredia, A., & Andrés, A. (2017). Evaluation studies of persimmon plant (Diospyros kaki) for physiological benefits and bioaccessibility of antioxidants by in vitro simulated gastrointestinal digestion. Food Chem., 214, 478–485. https://doi.org/10.1016/j.foodchem.2016.07.104

Iloki-Assanga, S. B., Lewis-Luján, L. M., Lara-Espinoza, C. L., Gil-Salido, A. A., Fernandez-Angulo, D., Rubio-Pino, J. L., & Haines, D. D. (2015). Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum Complementary and Alternative Medicine. BMC Res. Notes, 8. https://doi.org/10.1186/s13104-015-1388-1

Jang, I. C., Jo, E. K., Bae, M. S., Lee, H. J., Jeon, G. I., Park, E., Yuk, H. G., Ahn, G. H., & Lee, S. C. (2010). Antioxidant and antigenotoxic activities of different parts of persimmon (Diospyros kaki cv. Fuyu) fruit. J. Med. Plant. Res., 4, 155–160.

Jang, I. C., Oh, W. G., Lee, S. C., Ahn, G. H., & Lee, J. H. (2011). Antioxidant activity of 4 cultivars of persimmon fruit. Food Sci. Biotechnol., 20, 71–77. https://doi.org/10.1007/s10068-011-0010-0

Jiang, J., Leong, N. L., Mung, J. C., Hidaka, C., & Lu, H. H. (2008). Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP. Osteoarthritis and Cartilage, 16(1), 70–82. https://doi.org/10.1016/j.joca.2007.05.014

Jo, E., Lee, S. R., Park, B. S., & Kim, J. S. (2012). Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting. Aging Clin. Exp. Res., 24, 412–422. https://doi.org/10.3275/8464

Jones, T. E., Stephenson, K. W., King, J. G., Knight, K. R., Marshall, T. L., & Scott, W. B. (2009). Sarcopenia - mechanisms and treatments. J. Geriatr. Phys. Ther., 32, 39–45. https://doi.org/10.1519/00139143-200932020-00008

Joseph, A. M., Adhihetty, P. J., & Leeuwenburgh, C. (2016). Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J. Physiol., 594, 5105–5123. https://doi.org/10.1113/JP270659

Jung, S. T., Park, Y. S., Zachwieja, Z., Folta, M., Barton, H., Piotrowicz, J., Katrich, E., Trakhtenberg, S., & Gorinstein, S. (2005). Some essential phytochemicals and the antioxidant potential in fresh and dried persimmon. Int. J. Food Sci. Nutr., 56, 105–113. https://doi.org/10.1080/09637480500081571

Kämpfer, A. A. M., Urbán, P., Gioria, S., Kanase, N., Stone, V., & Kinsner-Ovaskainen, A. (2017). Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state. Toxicol. In Vitro, 45, 31–43. https://doi.org/10.1016/j.tiv.2017.08.011

Kang, J. S., Han, M. H., Kim, G. Y., Kim, C. M., Chung, H. Y., Hwang, H. J., Kim, B. W., & Choi, Y. H. (2015). Schisandrae semen essential oil attenuates oxidative stress-induced cell damage in C2C12 murine skeletal muscle cells through Nrf2- mediated upregulation of HO-1. Int. J. Mol. Med., 35, 453–459. https://doi.org/10.3892/ijmm.2014.2028

Kang, J. S., Kim, D. J., Kim, G. Y., Cha, H. J., Kim, S., Kim, H. S., Park, C., Hwang, H. J., Kim, B. W., Kim, C. M., & Choi, Y. H. (2016). Ethanol extract of Prunus mume fruit attenuates hydrogen peroxide-induced oxidative stress and apoptosis involving Nrf2/Ho-1 activation in C2C12 myoblasts. Rev. Bras. Farmacogn., 26, 184–190. https://doi.org/10.1016/j.bjp.2015.06.012

Kang, J. S., Kim, S. O., Kim, G. Y., Hwang, H. J., Kim, B. W., Chang, Y. C., Kim, W. J., Kim, C. M., Yoo, Y. H., & Choi, Y. H. (2016). An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts. Int. J. Mol. Med., 37, 149–156. https://doi.org/10.3892/ijmm.2015.2398

Kang, S. S., Choi, I. W., Han, H. H., Hong, H. H., Kim, O. O., Kim, G. Y., Hwang, J. J., Kim, W. W., Choi, T. T., Kim, M. M., & Choi, H. H. (2015). Sargassum horneri methanol extract rescues C2C12 murine skeletal muscle cells from oxidative stress- induced cytotoxicity through Nrf2-mediated upregulation of heme oxygenase-1. BMC Complement. Altern. Med., 15. https://doi.org/10.1186/s12906-015-0538-2

Kashif, M., Akhtar, N., & Mustafa, R. (2017). An overview of dermatological and cosmeceutical benefits of diospyros kaki and its phytoconstituents. Rev. Bras. Farmacogn., 27, 650–662. https://doi.org/10.1016/j.bjp.2017.06.004

Kawase, M., Motohashi, N., Satoh, K., Sakagami, H., Nakashima, H., Tani, S., Shirataki, Y., Kurihara, T., Spengler, G., Wolfard, K., & Molnár, J. (2003). Biological activity of persimmon (Diospyros kaki) peel extracts. Phytother. Res., 17, 495–500. https://doi.org/10.1002/ptr.1183

Kedare, S. B., & Singh, R. P. (2011). Genesis and development of DPPH method of antioxidant assay. J. Food Sci. Technol., 48, 412–422. https://doi.org/10.1007/s13197-011-0251-1

Khan, M. M., Tran, B. Q., Jang, Y. J., Park, S. H., Fondrie, W. E., Chowdhury, K., Yoon, S. H., Goodlett, D. R., Chae, S. W., Chae, H. J., Seo, S. Y., & Goo, Y. A. (2017). Assessment of the therapeutic potential of persimmon leaf extract on prediabetic subjects. Mol. Cells, 40, 466–475. https://doi.org/10.14348/molcells.2017.2298

Kim, L., Kim, Y., Kwon, O., & Kim, J. Y. (2017). Antioxidant activities of ethanolic and acidic ethanolic extracts of astringent persimmon in H2O2-stimulated Caco-2 human colonic epithelial cells. Food Sci. Biotechnol., 26(4), 1085–1091. https://doi.org/10.1007/s10068-017-0156-5

Koltai, E., Hart, N., Taylor, A. W., Goto, S., Ngo, J. K., Davies, K. J. A., & Radak, Z. (2012). Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am. J. Physiol. Regul. Integr. Comp. Physiol., 303. https://doi.org/10.1152/ajpregu.00337.2011

Kondo, S., Yoshikawa, H., & Katayama, R. (2004). Antioxidant activity in astringent and non-astringent persimmons. Journal of Horticultural Science and Biotechnology, 79(3), 390–394. https://doi.org/10.1080/14620316.2004.11511778

Kotani, M., Matsumoto, M., Fujita, A., Higa, S., Wang, W., Suemura, M., Kishimoto, T., & Tanaka, T. (2000). Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/NGa mice. J. Allergy Clin. Immunol., 106, 159–166. https://doi.org/10.1067/mai.2000.107194

Kregel, K. C., & Zhang, H. J. (2007). An integrated view of oxidative stress in aging: Basic mechanisms, functional effects, and pathological considerations. Am. J. Physiol. Regul. Integr. Comp. Physiol., 292, R18–R36. https://doi.org/10.1152/ajpregu.00327.2006

Kujoth, C. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., Morrow, J. D., Van Remmen, H., Sedivy, J. M., Yamasoba, T., Tanokura, M., Weindruch, R., Leeuwenburgh, C., & Prolla, T. A. (2005). Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science, 309, 481–484. https://doi.org/10.1126/science.1112125

Lee, J. H., Lee, Y. B., Seo, W. D., Kang, S. T., Lim, J. W., & Cho, K. M. (2012). Comparative studies of antioxidant activities and nutritional constituents of persimmon juice (Diospyros kaki L. cv. Gapjubaekmok). Prev. Nutr. Food Sci., 17, 141–151. https://doi.org/10.3746/pnf.2012.17.2.141

Lee, M. H., Han, M. H., Lee, D. S., Park, C., Hong, S. H., Kim, G. Y., Hong, S. H., Song, K. S., Choi, I. W., Cha, H. J., & Choi, Y. H. (2017). Morin exerts cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2- dependent HO-1 expression and the activation of the ERK pathway. Int. J. Mol. Med., 39, 399–406. https://doi.org/10.3892/ijmm.2016.2837

Lee, Y. A., Cho, E. J., & Yokozawa, T. (2008). Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence. Biological and Pharmaceutical Bulletin, 31(6), 1265–1269. https://doi.org/10.1248/bpb.31.1265

Leng, S. X., Xue, Q. L., Tian, J., Huang, Y., Yeh, S. H., & Fried, L. P. (2009). Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: Results from the Women’s Health and Aging Studies I. Exp. Gerontol., 44, 511–516. https://doi.org/10.1016/j.exger.2009.05.005

Li, C., Huang, W. Y., Wang, X. N., & Liu, W. X. (2013). Oxygen radical absorbance capacity of different varieties of strawberry and the antioxidant stability in storage. Molecules, 18, 1528–1539. https://doi.org/10.3390/molecules18021528

Liu, J., Saul, D., Böker, K. O., Ernst, J., Lehman, W., & Schilling, A. F. (2018). Current methods for skeletal muscle tissue repair and regeneration. Biomed. Res. Int., 2018. https://doi.org/10.1155/2018/1984879

Liu, R. H. (2004). Potential synergy of phytochemicals in cancer prevention: mechanism of action. The Journal of Nutrition, 134, 3479S-3485S. https://doi.org/10.1093/jn/134.12.3479s

López-otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging longevity. Cell, 153, 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039.The

Lordan, S., Ross, R. P., & Stanton, C. (2011). Marine bioactives as functional food ingredients: Potential to reduce the incidence of chronic diseases. Mar. Drugs, 9, 1056–1100. https://doi.org/10.3390/md9061056

Lourenço, S. C., Moldão-Martins, M., & Alves, V. D. (2019). Antioxidants of natural plant origins: from sources to food industry applications. Molecules, 24. https://doi.org/10.3390/molecules24224132

Mallavadhani, U. V., Panda, A. K., & Rao, Y. R. (1998). Pharmacology and chemotaxonomy of Diospyros. Phytochemistry, 49, 901–951. https://doi.org/10.1016/S0031-9422(97)01020-0

Malta, L. G., & Liu, R. H. (2014). Analyses of total phenolics, total flavonoids, and total antioxidant activities in foods and dietary supplements. In Encyclopedia of Agriculture and Food Systems (Vol. 1). Elsevier Ltd. https://doi.org/10.1016/B978- 0-444-52512-3.00058-9

Mandal, N., Mandal, S., Hazra, B., Sarkar, R., & Biswas, S. (2011). Assessment of the antioxidant and reactive oxygen species scavenging activity of methanolic extract of Caesalpinia crista leaf. Evid. Based Complement. Alternat. Med., 2011. https://doi.org/10.1093/ecam/nep072

Marzetti, E., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, Stephanie E. Dupont- Versteegden, E. E., Carter, C. S., & Bernabei, Roberto Leeuwenburgh, C. (2010). Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim. Biophys. Acta., 1800, 235–244. https://doi.org/10.1016/j.bbagen.2009.05.007.Mitochondrial

Masuda, H., Hironaka, S., Matsui, Y., Hirooka, S., Hirai, M., Hirata, Y., Akao, M., & Kumagai, H. (2015). Comparative study of the antioxidative activity of culinary herbs and spices, and hepatoprotective effects of three selected Lamiaceae plants on carbon tetrachloride-induced oxidative stress in rats. Food Sci. Technol. Res., 21, 407–418. https://doi.org/10.3136/fstr.21.407

McBride, H. M., Neuspiel, M., & Wasiak, S. (2006). Mitochondria: More Than Just a Powerhouse. Current Biology, 16, R551–R560. https://doi.org/10.1016/j.cub.2006.06.054

Meng, S. J., & Yu, L. J. (2010). Oxidative stress, molecular inflammation and sarcopenia. Int. J. Mol. Sci., 11, 1509–1526. https://doi.org/10.3390/ijms11041509

Moharram, H. A., & Youssef, M. M. (2014). Methods for determining the antioxidant activity: a review. Alex. J. Fd. Sci. & Technol., 11, 31–41. https://doi.org/10.12816/0025348

Mourkioti, F., & Rosenthal, N. (2005). IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol., 26, 535–542. https://doi.org/10.1016/j.it.2005.08.002

Mukherjee, T., Squillantea, E., Gillespieb, M., & Shao, J. (2004). Transepithelial electrical resistance is not a reliable measurement of the caco-2 monolayer integrity in transwell. Drug Deliv., 11, 11–18. https://doi.org/10.1080/10717540490280345

Nallamuthu, I., Tamatam, A., & Khanum, F. (2014). Effect of hydroalcoholic extract of Aegle marmelos fruit on radical scavenging activity and exercise-endurance capacity in mice. Pharm. Biol., 52, 551–559. https://doi.org/10.3109/13880209.2013.850518

Nizioł-ŁUkaszewska, Z., Furman-Toczek, D., & Zagórska-Dziok, M. (2018). Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells. Lipids Health Dis., 17. https://doi.org/10.1186/s12944-018-0929-8

Ogbole, O. O., Segun, P. A., & Adeniji, A. J. (2017). In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts. BMC Complement Altern Med, 17. https://doi.org/10.1186/s12906-017-2005-8

Ono, T., Isobe, K., Nakada, K., & Hayashi, J. (2001). Protection of human cells from mitochondrial dysfunction by exchange of mitochondrial DNA products between mitochondria. Nature Genetics, 28. Ou, B., Hampsch-Woodill, M., & Prior, R. L. (2001). Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay Using Fluorescein as the Fluorescent Probe. Journal of Agricultural and Food Chemistry, 49, 4619−4626. https://doi.org/10.1051/jp2:1995126

Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J. H., Chen, S., Corpe, C., Levine, M., Dutta, A., & Dutta, S. K. (2003). Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. Journal of the American College of Nutrition, 22(1), 18–35. https://doi.org/10.1080/07315724.2003.10719272

Park, S. Bin, Park, G. H., Song, H. M., Son, H. J., Um, Y., Kim, H. S., & Jeong, J. B. (2017). Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. BMC Complement. Altern. Med., 17. https://doi.org/10.1186/s12906-017-1954-2

Phang, C. W., Malek, S. N. A., Ibrahim, H., & Wahab, N. A. (2011). Antioxidant properties of crude and fractionated extracts of Alpinia mutica rhizomes and their total phenolic content. Afr. J. Pharm. Pharmacol, 5, 842–852.

Pisoschi, A. M., Pop, A., Cimpeanu, C., & Predoi, G. (2016). Antioxidant capacity determination in plants and plant-derived products: A review. Oxidative Medicine and Cellular Longevity, 2016. https://doi.org/10.1155/2016/9130976

Pitz, H. D. S., Pereira, A., Blasius, M. B., Voytena, A. P. L., Affonso, R. C. L., Fanan, S., Trevisan, A. C. D., Ribeiro-Do-Valle, R. M., & Maraschin, M. (2016). In vitro evaluation of the antioxidant activity and wound healing properties of Jaboticaba (Plinia peruviana) fruit peel hydroalcoholic extract. Oxid. Med. Cell Longev., 2016. https://doi.org/10.1155/2016/3403586

Receno, C. N., Liang, C., Korol, D. L., Atalay, M., Heffernan, K. S., Brutsaert, T. D., & Deruisseau, K. C. (2019). Effects of prolonged dietary curcumin exposure on skeletal muscle biochemical and functional responses of aged male rats. Int. J. Mol. Sci., 20. https://doi.org/10.3390/ijms20051178

Reid, M. B., & Li, Y. P. (2001). Tumor necrosis factor-α and muscle wasting: a cellular perspective. Respir. Res., 2, 269–272. https://doi.org/10.1186/rr67

Rein, M. J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S. K., & da Silva Pinto, M. (2012). Bioavailability of bioactive food compounds: a challenging journey to bioefficacy. Br J Clin Pharmacol, 75, 588–602. https://doi.org/10.1111/j.1365-2125.2012.04425.x

Rosenberg, I. H. (1997). Sarcopenia: origins and clinical relevance. J. Nutr., 127, 990– 991.

Sambruy, Y., Ferruzza, S., Ranaldi, G., & Angelis, I. De. (2001). Intestinal cell culture models. In Cell Biology and Toxicology (17th ed., pp. 301–317). Kluwer Academic Publishers.

Santilli, V., Bernetti, A., Mangone, M., & Paoloni, M. (2014). Clinical definition of sarcopenia. Clin. Cases Miner. Bone Metab., 11, 177–180. https://doi.org/10.11138/ccmbm/2014.11.3.177

Satsu, H. (2017). Molecular and cellular studies on the absorption, function, and safety of food components in intestinal epithelial cells. Bioscience, Biotechnology and Biochemistry, 81(3), 419–425. https://doi.org/10.1080/09168451.2016.1259552

Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006). Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am. J. Med., 119, 526.e9-526.e17. https://doi.org/10.1016/j.amjmed.2005.10.049

Seelinger, M., Popescu, R., Seephonkai, P., Singhuber, J., Giessrigl, B., Unger, C., Bauer, S., Wagner, K. H., Fritzer-Szekeres, M., Szekeres, T., Diaz, R., Tut, F. M., Frisch, R., Feistel, B., Kopp, B., & Krupitza, G. (2012). Fractionation of an extract of Pluchea odorata separates a property indicative for the induction of cell plasticity from one that inhibits a neoplastic phenotype. Evid. Based Complement. Alternat. Med., 2012. https://doi.org/10.1155/2012/701927

Seene, T., & Kaasik, P. (2012). Muscle weakness in the elderly: role of sarcopenia, dynapenia, and possibilities for rehabilitation. Eur. Rev. Aging. Phys. Act., 9, 109–117. https://doi.org/10.1007/s11556-012-0102-8

Sharma, P., Jha, A. B., Dubey, R. S., & Pessarakli, M. (2012). Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. J. Bot., 2012. https://doi.org/10.1155/2012/217037

Shon, M. S., Lee, Y., Song, J. H., Park, T., Lee, J. K., Kim, M., Park, E., & Kim, G. N. (2014). Anti-aging potential of extracts prepared from fruits and medicinal herbs cultivated in the Gyeongnam area of Korea. Prev. Nutr. Food Sci., 19, 178–186. https://doi.org/10.3746/pnf.2014.19.3.178

Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005). Decline in skeletal muscle mitochondrial function with aging in humans. Proc. Natl. Acad. Sci. U.S.A., 102, 5618–5623. https://doi.org/10.1073/pnas.0501559102

Smuder, A. J., Kavazis, A. N., Hudson, M. B., Nelson, W. B., & Powers, S. K. (2010). Oxidation enhances myofibrillar protein degradation via calpain and caspase-3. Free. Radic. Biol. Med., 49, 1152–1160. https://doi.org/10.1038/jid.2014.371

Sueishi, Y., Ishikawa, M., Yoshioka, D., Endoh, N., Oowada, S., Shimmei, M., Hirotada, F., & Kotake, Y. (2011). Oxygen radical absorbance capacity (ORAC) of cyclodextrin-solubilized flavonoids, resveratrol and astaxanthin as measured with the ORAC-EPR method. J. Clin. Biochem. Nutr., 50, 127–132. https://doi.org/10.3164/jcbn.11

Sun, D., Martinez, C. O., Ochoa, O., Ruiz‐Willhite, L., Bonilla, J. R., Centonze, V. E., Waite, L. L., Michalek, J. E., McManus, L. M., & Shireman, P. K. (2009). Bone marrow‐derived cell regulation of skeletal muscle regeneration. FASEB J., 23, 382–395. https://doi.org/10.1096/fj.07-095901

Tan, H. Y., Trier, S., Rahbek, U. L., Dufva, M., Kutter, J. P., & Andresen, T. L. (2018). A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies. PLoS ONE, 13, e0197101. https://doi.org/10.1371/journal.pone.0197101

Tidball, J. G. (2017). Regulation of muscle growth and regeneration by the immune system. Nat. Rev. Immunol., 17, 165–178. https://doi.org/10.1038/nri.2016.150 Timoshnikov, V. A., Kobzeva, T. V., Polyakov, N. E., & Kontoghiorghes, G. J. (2020).

Redox interactions of vitamin c and iron: Inhibition of the pro-oxidant activity by deferiprone. International Journal of Molecular Sciences, 21(11), 1–16. https://doi.org/10.3390/ijms21113967

Topinková, E. (2008). Aging, disability and frailty. Annals of Nutrition and Metabolism, 52(SUPPL. 1), 6–11. https://doi.org/10.1159/000115340

Toschi, T. G., Bordoni, A., Hrelia, S., Bendini, A., Lercker, G., & Biagi, P. L. (2000). The protective role of different green tea extracts after oxidative damage is related to their catechin composition. J. Agric. Food Chem., 48, 3973–3978. https://doi.org/10.1021/jf000499g

Toth, M. J., Matthews, D. E., Tracy, R. P., & Previs, M. J. (2005). Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am. J. Physiol. Endocrinol. Metab., 288, E883–E891. https://doi.org/10.1152/ajpendo.00353.2004

Tsao, R. (2010). Chemistry and biochemistry of dietary polyphenols. Nutrients, 2, 1231– 1246. https://doi.org/10.3390/nu2121231

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., Alroy, J., Wu, M., Py, B. F., Yuan, J., Deeney, J. T., Corkey, B. E., & Shirihai, O. S. (2008). Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J, 27, 433–446. https://doi.org/10.1038/sj.emboj.7601963

Venkatesan, T., Choi, Y. W., & Kim, Y. K. (2019). Impact of different extraction solvents on phenolic content and antioxidant potential of Pinus densiflora bark extract. Biomed. Res. Int., 2019. https://doi.org/10.1155/2019/3520675

Vinha, A. F., Soares, M. O., Herdeiro, T., & Machado, M. (2012). Chemical composition and antioxidant activity of Portuguese Diospyrus kaki fruit by geographical origins. J. Agric. Sci., 4, 281–289. https://doi.org/10.5539/jas.v4n2p281

Wang, C., & Youle, R. J. (2009). The role of mitochondria in apoptosis. Ann. Rev. Genet., 43, 95–118. https://doi.org/10.1146/annurev-genet-102108-134850

White, J. P., Puppa, M. J., Sato, S., Gao, S., Price, R. L., Baynes, J. W., Kostek, M. C., Matesic, L. E., & Carson, J. A. (2012). IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse. Skelet. Muscle, 2. https://doi.org/10.1186/2044-5040-2-14

Wilson, D., Jackson, T., Sapey, E., & Lord, J. M. (2017). Frailty and sarcopenia: The potential role of an aged immune system. Ageing Res. Rev., 36, 1–10. https://doi.org/10.1016/j.arr.2017.01.006

Wu, M., Liu, H., Fannin, J., Katta, A., Wang, Y., Arvapalli, R. K., Paturi, S., Karkala, S. K., Rice, K. M., & Blough, E. R. (2010). Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res, 13, 571–579. https://doi.org/10.1089/rej.2009.1015

Xia, Z., Cholewa, J., Zhao, Y., Shang, H. Y., Yang, Y. Q., Pessôa, K. A., Su, Q. S., Lima- Soares, F., & Zanchi, N. E. (2017). Targeting inflammation and downstream protein metabolism in sarcopenia: a brief up-dated description of concurrent exercise and leucine-based multimodal intervention. Front. Physiol., 8. https://doi.org/10.3389/fphys.2017.00434

Xie, C., Xie, Z., Xu, X., & Yang, D. (2015). Persimmon (Diospyros kaki L.) leaves: a review on traditional uses, phytochemistry and pharmacological properties. J. Ethnopharmacol., 163, 229–240. https://doi.org/10.1016/j.jep.2015.01.007

Yakes, F. M., & Van Houten, B. (1997). Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. U.S.A., 94, 514–519. https://doi.org/10.1073/pnas.94.2.514

Yalcin, G., & Sogut, O. (2014). Influence of extraction solvent on antioxidant capacity value of oleaster measured by ORAC method. Nat. Prod. Res, 28, 1513–1517. https://doi.org/10.1080/14786419.2014.913243

Yang, C., Jiang, L., Zhang, H., Shimoda, L. A., Deberardinis, R. J., & Semenza, G. L. (2014). Analysis of hypoxia-induced metabolic reprogramming. In Methods in Enzymology (1st ed., Vol. 542, pp. 425–455). Elsevier Inc. https://doi.org/10.1016/B978-0-12-416618-9.00022-4

Yaqub, S., Farooq, U., Shafi, A., Akram, K., Murtaza, M. A., Kausar, T., & Siddique, F. (2016). Chemistry and functionality of bioactive compounds present in persimmon. J. Chem., 2016. https://doi.org/10.1155/2016/3424025

Yoon, Y., Yoon, D., Lim, I. K., Yoon, S., Chung, H., Rojo, M., Malka, F., Jou, M., Martinou, J. C., & Yoon, G. (2006). Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J. Cell. Physiol., 209, 468–480. https://doi.org/10.1002/JCP

Zhang, Y. J., Gan, R. Y., Li, S., Zhou, Y., Li, A. N., Xu, D. P., Li, H. Bin, & Kitts, D. D. (2015). Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules, 20, 21138–21156. https://doi.org/10.3390/molecules201219753

Zhao, Z., Hee, S. S., Satsu, H., Totsuka, M., & Shimizu, M. (2008). 5-Caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-α-induced secretion of interleukin-8 from Caco-2 cells. Journal of Agricultural and Food Chemistry, 56(10), 3863–3868. https://doi.org/10.1021/jf073168d

Zhou, Z., Huang, Y., Liang, J., Ou, M., Chen, J., & Li, G. (2016). Extraction, purification and anti-radiation activity of persimmon tannin from Diospyros kaki L.f. J. Environ. Radioact., 162–163, 182–188. https://doi.org/10.1016/j.jenvrad.2016.05.034

Zillich, O. V., Schweiggert-Weisz, U., Eisner, P., & Kerscher, M. (2015). Polyphenols as active ingredients for cosmetic products. Int. J. Cosmet. Sci., 37, 455–464. https://doi.org/10.1111/ics.12218