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Analysis of Anti-metabolic Syndrome Effect of Kaempferol in TSOD Mice

淵上, 彩紗 筑波大学 DOI:10.15068/0002005489

2022.11.18

概要

Metabolic syndrome, which is a combination of obesity, hyperglycemia, dyslipidemia, and hypertention that increase the risk of atherosclerotic diseases, has become a global challenge. Kaempferol (KPF) is a dietary polyphenol reported to have various beneficial effects on human health. This study examined the effects of KPF on metabolic syndrome; obesity, dyslipidemia, and diabetes in TSOD (Tsumura, Suzuki, Obese Diabetes) mice. TSOD mice are spontaneous, multifactorial, visceral fat accumulation type obese mice known as a metabolic syndrome pathological model. Since the pathogenesis of metabolic syndrome in humans is largely related to genetic predisposition as well as diet and exercise, the analysis of TSOD mice will allow us to clarify the effects of KPF in a condition closer to that of humans than other conventional animal models.

　The 6-week administration of KPF decreased fat weight, serum total cholesterol, and low-density lipoproteins (LDLs); increased high-density lipoproteins (HDLs); and improved glucose tolerance. Additionally, there was tendency that NEFA were decreased by KPF.

　KPF increased LDL receptor (LDLR) and apolipoprotein A1 (ApoA1) gene expression and decreased serum resistin levels. These findings suggest that the decrease in LDL and the increase in HDL caused by KPF may be due to increases in hepatic LDLR and ApoA1 expression, respectively. Gene expression levels related to fatty acid synthesis were decreased and at the same time gene expression related to fatty acid oxidation were increased by KPF, which may play an important role in decreasing fat weight. Furthermore, it is possible that the improvement in glucose tolerance by KPF may occur via resistin reduction. This research revealed that KPF improved metabolic syndrome in TSOD mice for the first time and clarified newly parts of complex mechanisms by which KPF improves metabolic syndrome.

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