1.
Hayashida M, Miki A, Nakai S, Matsumiya W, Imai H, Kusuhara S, et al. Predictive factors of metamorphopsia after reduced-fluence photodynamic therapy in patients with central serous chorioretinopathy
with good baseline visual acuity. PLOS ONE. 2020; 15: e0240557. https://doi.org/10.1371/journal.
pone.0240557 PMID: 33044997
2.
Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, et al. Central serous chorioretinopathy:
recent findings and new physiopathology hypothesis. Prog Retin Eye Res. 2015; 48: 82–118. https://
doi.org/10.1016/j.preteyeres.2015.05.003 PMID: 26026923
3.
Tsai MJ, Hsieh YT. Half-time photodynamic therapy for central serous chorioretinopathy. Optom Vis
Sci. 2014; 91: 1140–1145. https://doi.org/10.1097/OPX.0000000000000360 PMID: 25083838
4.
Liu HY, Yang CH, Yang CM, Ho TC, Lin CP, Hsieh YT. Half-dose versus half-time photodynamic therapy for central serous chorioretinopathy. Am J Ophthalmol. 2016; 167: 57–64. https://doi.org/10.1016/j.
ajo.2016.04.001 PMID: 27084002
5.
Neves F, Costa J, Fonseca S, Silva L, Agrelos L. Half-dose photodynamic therapy for chronic central
serous chorioretinopathy: efficacy and safety outcomes in real world. Photodiagn Photodyn Ther. 2016;
14: 173–177. https://doi.org/10.1016/j.pdpdt.2016.04.012 PMID: 27126174
6.
Fujita K, Imamura Y, Shinoda K, Matsumoto CS, Mizutani Y, Hashizume K, et al. One-year outcomes
with half-dose verteporfin photodynamic therapy for chronic central serous chorioretinopathy. Ophthalmology. 2015; 122: 555–561. https://doi.org/10.1016/j.ophtha.2014.09.034 PMID: 25444637
7.
van Rijssen TJ, van Dijk EHC, Dijkman G, Boon CJF. Clinical characteristics of chronic central serous
chorioretinopathy patients with insufficient response to reduced-settings photodynamic therapy.
Graefes Arch Clin Exp Ophthalmol. 2018; 256: 1395–1402. https://doi.org/10.1007/s00417-018-4003z PMID: 29732468
8.
Hayashida M, Miki A, Honda S, Nakamura M. Comparison between the outcomes of fluorescein angiography-guided and indocyanine green angiography-guided half-time photodynamic therapy for central
serous chorioretinopathy. Photodiagn Photodyn Ther. 2020; 31: 101955. https://doi.org/10.1016/j.
pdpdt.2020.101955 PMID: 32818640
9.
Lai FH, Ng DS, Bakthavatsalam M, Chan VC, Young AL, Luk FO, et al. A multicenter study on the longterm outcomes of half-dose photodynamic therapy in chronic central serous chorioretinopathy. Am J
Ophthalmol. 2016; 170: 91–99. https://doi.org/10.1016/j.ajo.2016.07.026 PMID: 27519561
10.
Haga F, Maruko R, Sato C, Kataoka K, Ito Y, Terasaki H. Long-term prognostic factors of chronic central
serous chorioretinopathy after half-dose photodynamic therapy: A 3-year follow-up study. PLOS ONE.
2017; 12: e0181479. https://doi.org/10.1371/journal.pone.0181479 PMID: 28742138
11.
Fung AT, Yannuzzi LA, Freund KB. Type 1 (sub-retinal pigment epithelial) neovascularization in central
serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina.
2012; 32: 1829–1837. https://doi.org/10.1097/IAE.0b013e3182680a66 PMID: 22850219
12.
Shiragami C, Takasago Y, Osaka R, Kobayashi M, Ono A, Yamashita A, et al. Clinical Features of Central Serous Chorioretinopathy With Type 1 Choroidal Neovascularization. Am J Ophthalmol. 2018; 193:
80–86. https://doi.org/10.1016/j.ajo.2018.06.009 PMID: 29940168
13.
Sulzbacher F, Schu¨tze C, Burgmu¨ller M, Ve´csei-Marlovits PV, Weingessel B. Clinical evaluation of
neovascular and non-neovascular chronic central serous chorioretinopathy (CSC) diagnosed by
swept source optical coherence tomography angiography (SS octa). Graefes Arch Clin Exp Ophthalmol. 2019; 257: 1581–1590. https://doi.org/10.1007/s00417-019-04297-z PMID: 31037488
PLOS ONE | https://doi.org/10.1371/journal.pone.0284979 May 2, 2023
9 / 10
PLOS ONE
Treatment outcome of half-time PDT for chronic CSC with and without CNV
14.
Zhou X, Komuku Y, Araki T, Terasaki H, Miki A, Kuwayama S, et al. Risk factors and characteristics of
central serous chorioretinopathy with later development of macular neovascularisation detected on
OCT angiography: a retrospective multicentre observational study. BMJ Open Ophthalmol. 2022; 7.
https://doi.org/10.1136/bmjophth-2022-000976 PMID: 35537029
15.
Hwang S, Noh H, Kang SW, Kang MC, Lee D, Kim SJ. Choroidal neovascularization secondary to
photodynamic therapy for central serous chorioretinopathy: Incidence, Risk Factors, and Clinical
Outcomes. Retina. 2021; 41: 1762–1770. https://doi.org/10.1097/IAE.0000000000003067 PMID:
33315827
16.
Yang C, Chen K, Lee S, Lee F. Photodynamic therapy in the treatment of choroidal neovascularization
complicating central serous chorioretinopathy. J Chin Med Assoc. 2009; 72: 501–505. https://doi.org/
10.1016/S1726-4901(09)70417-4 PMID: 19762322
17.
Ergun E, Tittl M, Stur M. Photodynamic therapy with verteporfin in subfoveal choroidal neovascularization secondary to central serous chorioretinopathy. Arch Ophthalmol. 2004; 122: 37–41. https://doi.org/
10.1001/archopht.122.1.37 PMID: 14718292
18.
Chan WM, Lam DSC, Lai TYY, Yuen KSC, Liu DTL, Chan CKM, et al. Treatment of choroidal neovascularization in central serous chorioretinopathy by photodynamic therapy with verteporfin. Am J Ophthalmol. 2003; 136: 836–45. https://doi.org/10.1016/s0002-9394(03)00462-8 PMID: 14597034
19.
Hu YC, Chen YL, Chen YC, Chen SN. 3-year follow-up of half-dose verteporfin photodynamic therapy
for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization. Sci
Rep. 2021; 11: 13286. https://doi.org/10.1038/s41598-021-92693-z PMID: 34168238
20.
van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE, et al. HalfDose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in
Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial. Ophthalmology. 2018; 125:
1547–1555. https://doi.org/10.1016/j.ophtha.2018.04.021 PMID: 29776672
21.
Chubachi A, Miki A, Hayashida M, Sakamoto M, Imai H, Kusuhara S, et al. Clinical factors associated
with low-contrast visual acuity after reduced-fluence photodynamic therapy in patients with resolved
central serous chorioretinopathy and good baseline visual acuity. Pharmaceuticals (Basel). 2021; 14.
https://doi.org/10.3390/ph14040303 PMID: 33800693
22.
Chen YC, Chen SN. Three-year follow-up of choroidal neovascularisation in eyes of chronic central
serous chorioretinopathy. Br J Ophthalmol. 2020; 104: 1561–1566. https://doi.org/10.1136/
bjophthalmol-2019-315302 PMID: 32051140
23.
Smretschnig E, Hagen S, Glittenberg C, Ristl R, Krebs I, Binder S, et al. Intravitreal anti-vascular endothelial growth factor combined with half-fluence photodynamic therapy for choroidal neovascularization
in chronic central serous chorioretinopathy. Eye (Lond). 2016; 30: 805–811. https://doi.org/10.1038/
eye.2016.41 PMID: 26965012
24.
Miki A, Kusuhara S, Otsuji T, Kawashima Y, Miki K, Imai H, et al. Photodynamic therapy combined with
anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. PLOS ONE. 2021;
16: e0248760. https://doi.org/10.1371/journal.pone.0248760 PMID: 33755678
25.
Li M, Qu J, Liang Z, Tang J, Hu J, Yao Y, et al. Risk factors of persistent subretinal fluid after half-dose
photodynamic therapy for treatment-naïve central serous chorioretinopathy. Graefes Arch Clin Exp
Ophthalmol. 2022; 260: 2175–2182. https://doi.org/10.1007/s00417-021-05531-3 PMID: 35024912
26.
Bousquet E, Bonnin S, Mrejen S, Krivosic V, Tadayoni R, Gaudric A. Optical coherence tomography
angiography of flat irregular pigment epithelium detachment in chronic central serous chorioretinopathy.
Retina. 2018; 38: 629–638. https://doi.org/10.1097/IAE.0000000000001580 PMID: 28267114
PLOS ONE | https://doi.org/10.1371/journal.pone.0284979 May 2, 2023
10 / 10
...