リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Short-Term Outcomes of Faricimab Treatment in Aflibercept-Refractory Eyes with Neovascular Age-Related Macular Degeneration」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Short-Term Outcomes of Faricimab Treatment in Aflibercept-Refractory Eyes with Neovascular Age-Related Macular Degeneration

Kishi, Maya Miki, Akiko Kamimura, Aya Okuda, Mina Matsumiya, Wataru Imai, Hisanori Kusuhara, Sentaro Nakamura, Makoto 神戸大学

2023.08

概要

To evaluate the functional and anatomical effects of switching to faricimab for patients with neovascular age-related macular degeneration (nAMD) refractory to intravitreal aflibercept, this retrospective study evaluated patients with nAMD who received intravitreal injections of aflibercept (IVA) every <8 weeks and were switched to faricimab. After switching, the patients were treated with a treatment and extended regimen that started with the interval just before switching and received at least three injections. We evaluated changes in the best-corrected visual acuity (BCVA), central retinal thickness (CRT), central choroidal thickness (CCT), treatment interval, and presence of retinal fluid. Overall, 55 eyes from 55 patients were examined. After three injections of faricimab, the BCVA and CCT did not change significantly. However, the CRT decreased significantly (p < 0.05), the injection interval was significantly extended (7.5 ± 2.3 vs. 5.9 ± 1.5 weeks, p < 0.01), and the rates of the presence of intraretinal fluid and subretinal fluid decreased significantly to 16.4% and 40% of eyes, respectively (both p < 0.01). An ocular adverse event (retinal pigment epithelium tear) developed in one eye. Switching to faricimab was effective for anatomic changes. It may be an additional treatment option for some eyes refractory to IVA.

この論文で使われている画像

参考文献

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

Lim, L.S.; Mitchell, P.; Seddon, J.M.; Holz, F.G.; Wong, T.Y. Age-related macular degeneration. Lancet 2012, 379, 1728–1738.

[CrossRef]

Ohji, M.; Takahashi, K.; Okada, A.A.; Kobayashi, M.; Matsuda, Y.; Terano, Y.; ALTAIR Investigators. Efficacy and safety of

intravitreal aflibercept treat-and-extend regimens in exudative age-related macular degeneration: 52- and 96-week findings from

ALTAIR: A randomized controlled trial. Adv. Ther. 2020, 37, 1173–1187. [CrossRef]

Ramakrishnan, M.S.; Yu, Y.; VanderBeek, B.L. Association of visit adherence and visual acuity in patients with neovascular

age-related macular degeneration: Secondary analysis of the comparison of age-related macular degeneration treatment trial.

JAMA Ophthalmol. 2020, 138, 237–242. [CrossRef]

Heier, J.S.; Khanani, A.M.; Ruiz, C.Q.; Basu, K.; Ferrone, P.J.; Brittain, C.; Figueroa, M.S.; Lin, H.; Holz, F.G.; Patel, V.; et al. Efficacy,

durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA

and LUCERNE): Two randomised, double-masked, phase 3, non-inferiority trials. Lancet 2022, 399, 729–740. [CrossRef]

Spaide, R.F.; Jaffe, G.J.; Sarraf, D.; Freund, K.B.; Sadda, S.R.; Staurenghi, G.; Waheed, N.K.; Chakravarthy, U.; Rosenfeld, P.J.;

Holz, F.G.; et al. Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on

Neovascular Age-Related Macular Degeneration Nomenclature Study Group. Ophthalmology 2020, 127, 616–636. [CrossRef]

Rush, R.B.; Rush, S.W. Intravitreal faricimab for aflibercept-resistant neovascular age-related macular degeneration. Clin. Ophthalmol.

2022, 16, 4041–4046. [CrossRef]

Stanga, P.E.; Valentín-Bravo, F.J.; Stanga, S.E.F.; Reinstein, U.I.; Pastor-Idoate, S.; Downes, S.M. Faricimab in neovascular AMD:

First report of real-world outcomes in an independent retina clinic. Eye 2023. Online ahead of print. [CrossRef]

Ahn, J.; Hwang, D.D.-J.; Sohn, J.H.; Son, G. Retinal pigment epithelium tears after anti-vascular endothelial growth factor therapy

for neovascular age-related macular degeneration. Ophthalmologica 2022, 245, 1–9. [CrossRef]

Chan, C.K.A.P.; Meyer, C.H.; Kokame, G.T.; Kaiser, P.K.; Rauser, M.E.; Gross, J.G.; Nuthi, A.S.; Lin, S.G.; Daher, N.S. Optical

coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears

associated with intravitreal bevacizumab injections. Retina 2010, 30, 203–211. [CrossRef]

Chan, C.K.M.C.; Gross, J.G.; Abraham, P.; Nuthi, A.S.; Kokame, G.T.; Lin, S.G.; Rauser, M.E.; Kaiser, P.K. Retinal pigment

epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration. Retina 2007, 27, 541–551.

[CrossRef]

J. Clin. Med. 2023, 12, 5145

11.

12.

8 of 8

Chiang, A.; Chang, L.K.; Yu, F.; Sarraf, D. Predictors of anti-VEGF-associated retinal pigment epithelial tear using FA and OCT

analysis. Retina 2008, 28, 1265–1269. [CrossRef]

Clemens, C.R.; Alten, F.; Eter, N. Reading the signs: Microrips as a prognostic sign for impending RPE tear development.

Acta Ophthalmol. 2015, 93, e600–e602. [CrossRef]

Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual

author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to

people or property resulting from any ideas, methods, instructions or products referred to in the content.

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る