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The dynamic pulmonary functional change after thoracoscopic lower lobe segmentectomy

Kuroda, Sanae Tane, Shinya Kitamura, Yoshitaka Maniwa, Yoshimasa Nishio, Wataru 神戸大学

2023.03

概要

Background The advantages of segmentectomy over lobectomy in sparing pulmonary function remain controversial. Lower lobe segmentectomy is divided into simple segmentectomy, such as segment 6; and complex segmentectomy that includes the basal segments. Here, we compared residual lung function after thoracoscopic segmentectomy versus lobectomy in the lower lobe using the three-dimensional computed tomography volumetric method. Methods Between January 2012 and October 2020, 67 patients who underwent thoracoscopic segmentectomy of the lower lobe were matched to 67 patients who underwent thoracoscopic lower lobectomy during the same period using propensity score matching analysis. The postoperative decrease in the rate of forced expiratory volume in 1 s was compared between methods. The regional forced expiratory volume in 1 s of the residual lobe rescued by segmentectomy was measured using volumetric and spirometric analyses and compared to lower lobectomy. The ratio of the actual to predicted postoperative forced expiratory volume in 1 s in the residual lobe was defined as the preservation rate. Results Of the 67 thoracoscopic segmentectomies, 43 were S6, seven were S8, three were S8  +  9, seven were S10, and seven were S9  +  10. The percentage of postoperative/preoperative forced expiratory volume in 1 s was significantly higher in the segmentectomy versus lobectomy group (90.7% vs. 85.7%, p  =  0.001). The preservation rates after simple segmentectomy (n  =  43) and complex segmentectomy (n  =  24) did not differ significantly (82.2% vs. 80.2%, p  =  0.709). Conclusions Thoracoscopic lower lobe segmentectomy versus lobectomy preserves postoperative lung function. Even complex segmentectomy exhibited outcomes relevant to simple segmentectomy by sparing the residual lobe.

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参考文献

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Table 1,

Table 1. Patients Characteristics After Propensity Score Matching

Segmentectomy

Lobectomy

(n = 67)

(n = 67)

Age,y

Gender

Male

69.5

69.4

44

41

Female

Smoking History (PY)

Diagnosis

Lung Cancer

Metastases

Malignant lymphoma

Benign diseases

Preoperative FEV1.0/FVC, %

Preoperative FEV1.0, L

Postoperative FEV1.0, L

Resected location

Right

S6

S8

S8+9

S10

S9+10

Left

S6

S8

S8+9

S10

23

28.6

26

23.6

57

73.7

2.23 ± 0.68

2.02 ± 0.63

64

73.7

2.31 ± 0.66

1.98 ± 0.61

34

22

33

21

46

Characteristics

S9+10

Operating time, min

Blood loss, mL

190 ± 58

47.9 ± 60.1

P value

0.928

0.594

0.373

0.049

0.995

0.478

0.704

0.035

21

180 ± 44

74.6 ± 87.2

0.250

0.041

17

Postoperative complications

Prolonged air leak *

Pneumonia

Empyema

Interstitial pneumonia

Atrial fibrillation

Cerebral infarction

8 (11.9)

9 (13.4)

0.797

*Prolonged air leak was defined as air leak lasting longer than 7 days or the use of

pleurodesis.

Value are n, mean ± SD, or n (%)

FEV1.0, forced expiratory volume in 1 second.

PY, pack-year.

18

Table 2,

Table 2. Comparison of patient characteristics and perioperative outcomes between COPD and

non-COPD patients who underwent segmentectomy.

Characteristics

Age,y

Gender

Male

Female

Smoking History (PY)

Postoperative complications

Prolonged air leak *

Pneumonia

Empyema

Atrial fibrillation

COPD

FEV1.0/FVC < 70%

(n= 19)

68.7

17

49.1

4 (21.1)

non-COPD

FEV1.0/FVC ≥ 70%

(n = 48)

71.7

27

21

20.4

4 (8.3)

P-value

0.228

0.009

0.002

0.152

*Prolonged air leak was

defined as air leak lasting longer

than 7 days or the use of

pleurodesis.

Value are n, mean ± SD, or n

(%)

FEV1.0, forced expiratory volume in 1 second.

FVC, forced vital capacity.

PY, pack-year.

19

Figure legends

Figure 1,

A representative case of thoracoscopic left S10 segmentecomy.

A, Computed tomography findings showing a solid nodule (yellow arrow) in the left S10c.

B, Three-dimensional vasculature image and visual guidance of virtual S10 segmentectomy

produced by the Synapse Vincent.

C, After ligation of the segmental artery, vein, and bronchus, the intersegmental plane was

identified using a systemic indocyanine green injection.

D, Operative view after S10 segmentectomy. The intersegmental plane was dissected to preserve

10

the intersegmental veins.

11

12

Figure 2,

13

The regional FEV1.0 of the residual lobe rescued by segmentectomy was measured from the

14

volumetric and spirometric parameters.

15

16

Figure 3,

17

Comparison of the percentage of postoperative/preoperative of FEV1.0 (A) between

18

segmentectomy and lobectomy in the lower lobe, and (B) simple, complex segmentectomy, and

19

lobectomy.

20

21

Figure 4,

20

The change in the left upper residual lobe volume before and after simple (S6) and complex (S10)

segmentectomy (A, C). There were no significant differences in predicted and actual residual lobe

volume (S6; p=0.191, complex; p=0.115) (B, D).

Figure 5,

Comparison of the preservation rate of the residual lobe between simple (S6) and complex

segmentectomies. The preservation rate was not significant different in simple and complex

segmentectomies (p=0.71).

10

21

Figure 1

22

Figure 2

23

Figure 3

24

Figure 4

25

Figure 5

26

...

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