論文の公開元へGenotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma (本文)
概要
Lung cancer (LC) is the leading cause of cancer-related deaths,
accounting for approximately 1.8 million annual mortalities or
18% of all cancer-related deaths worldwide.1 LC is a heterogeneous disease that broadly encompasses two major categories:
small cell LC (SCLC) and non-SCLC. The latter mainly consists of
lung adenocarcinoma (LUAD), lung squamous cell carcinoma
(LUSC), and a rare histologic subtype, large cell neuroendocrine
carcinoma (LCNEC). Of these subtypes, chemotherapy for
LUAD, which dominates approximately 60% of all LC cases
and is responsible for the majority of LC-related deaths, has
been rapidly evolving owing to the discovery of molecular
targets2 and the development of targeted drugs that show clinical activity. The list of such druggable molecular targets,
including EGFR, KRASG12C, and BRAFV600E mutations, and
ALK-, ROS1-, RET-, and NTRK-translocations,3–6 has continued
to expand owing to large-scale sequencing efforts. ...
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