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大学・研究所にある論文を検索できる 「Immunohistochemical assessment of sex-determining region Y (SRY)-related high mobility group (HMG)-box 2 (Sox2) and Krüppel-like factor 4 (Klf4) in ameloblastomas」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Immunohistochemical assessment of sex-determining region Y (SRY)-related high mobility group (HMG)-box 2 (Sox2) and Krüppel-like factor 4 (Klf4) in ameloblastomas

黒田 佳奈子 東北大学

2021.03.25

概要

Background: To investigate the possible roles of stem cell-related molecules in odontogenic tissues, the expression of sex-determining region Y (SRY)- related high mobility group (HMG)-box 2 (Sox2) and Krüppel-like factor 4 (Klf4) was examined in ameloblastomas and in dental follicles.

Methods: Immunohistochemical reactivity for Sox2 and Klf4 was examined in 10 dental follicle and 54 ameloblastoma specimens. The association between these molecules and clinical variables was analyzed in ameloblastoma cases.

Results: Dental follicles showed immunoreactivity for Sox2 and Klf4 predominantly in dental lamina. In ameloblastomas, expression of Sox2 and Klf4 was detected in 48 of 54 cases, respectively, and was predominantly localized in neoplastic cells neighboring the basement membrane. Sox2 reactivity was significantly higher in dental follicles than in ameloblastomas. Granular cell ameloblastomas tended to show lower reactivity for Sox2 and Klf4 than acanthomatous ameloblastomas. Immunoreactivity for Sox2 and Klf4 in ameloblastomas was slightly higher in recurrence-positive cases than in non-recurrent cases.

Conclusion: Patterns of Sox2 and Klf4 reactivity in dental follicles and ameloblastomas suggest that these molecules might be associated with the regulation of odontogenic tissues. These molecules were considered to be correlated with cell proliferation and differentiation of odontogenic epithelium and might contribute to tumorigenesis or disease prognosis.

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