リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Annexin A10 is involved in the induction of pancreatic duodenal homeobox-1 in gastric cancer tissue, cells and organoids」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Annexin A10 is involved in the induction of pancreatic duodenal homeobox-1 in gastric cancer tissue, cells and organoids

石川 洸 広島大学

2020.03.23

概要

Gastric cancer (GC) is the third leading cause of cancer‑related
death in the world (1). A deeper understanding of the patho‑
genesis and biological features of GC is necessary to further
enhance early detection and treatment methods. The identifi‑
cation of novel biomarkers, which could become both potent
new tools for the diagnosis of GC and targets for treatment,
is one of the main strategies for improving the diagnosis and
treatment of GC (2). In addition to the Lauren histology‑based
classification (3), GC can be subdivided into four phenotypes
according to mucin expression (2). Accumulating evidence
suggests that the gastric/intestinal mucin phenotypes of GC
have different clinical characteristics and specific genetic and
epigenetic changes (4). Thus, the classification of the subtype
of GC is important for clinical decision‑making.
Annexin A10 (ANXA10), a calcium‑/phospholipid‑binding
protein, is a member of the Annexin family. It has been
reported that Annexin family proteins play important roles
in calcium signaling, cell motility, differentiation and prolif‑
eration (5,6). Expression of ANXA10 is observed in foveolar
and glandular cells of the normal antral or the body‑type
gastric mucosa in the stomach (7,8). Other normal organs,
including the duodenum and urothelial epithelium, also show
the robust expression of ANXA10 (8). With regard to cancer
tissue, the expression of ANXA10 has been observed in
several types of cancer, including GCs, but the clinical signifi‑
cance of ANXA10 is still controversial in various types of
cancer (8‑13). In colorectal adenocarcinomas, several studies
that have confirmed the induction of the expression of gastric
mucins in serrated neoplasms have shown that the aberrant
expression of ANXA10 is significantly correlated with gastric
differentiation (14‑17). ...

この論文で使われている画像

参考文献

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C,

Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence

and mortality worldwide: Sources, methods and major patterns

in GLOBOCAN 2012. Int J Cancer 136: E359‑E386, 2015.

2. Oue N, Sentani K, Sakamoto N and Yasui W: Clinicopathologic

and molecular characteristics of gastric cancer showing

gastric and intestinal mucin phenotype. Cancer Sci 106:

951‑958, 2015.

3. Lauren P: The two histological main types of gastric carcinoma:

Diffuse and so‑called intestinal‑type carcinoma. An attempt at

a histo‑clinical classification. Acta Pathol Microbiol Scand 64:

31‑49, 1965.

4. Endoh Y, Sakata K, Tamura G, Ohmura K, Ajioka Y, Watanabe H

and Motoyama T: Cellular phenotypes of differentiated‑type

adenocarcinomas and precancerous lesions of the stomach are

dependent on the genetic pathways. J Pathol 191: 257‑263, 2000.

5. Ohnishi M, Tokuda M, Masaki T, Fujimura T, Tai Y, Matsui H,

Itano T, Ishida T, Takahara J and Konishi R: Changes in annexin I

and II levels during the postnatal development of rat pancreatic

islets. J Cell Sci 107: 2117‑2125, 1994.

6. Gerke V and Moss SE: Annexins: From structure to function.

Physiol Rev 82: 331‑371, 2002.

7. Lu SH, Chen YL, Shun CT, Lai JN, Peng SY, Lai PL and Hsu HC:

Expression and prognostic significance of gastric‑specific

annexin A10 in diffuse‑ and intestinal‑type gastric carcinoma.

J Gastroenterol Hepatol 26: 90‑97, 2011.

8. Lu SH, Yuan RH, Chen YL, Hsu HC and Jeng YM: Annexin

A10 is an immunohistochemical marker for adenocarcinoma

of the upper gastrointestinal tract and pancreatobiliary system.

Histopathology 63: 640‑648, 2013.

9. Kodaira H, Koma YI, Hosono M, Higashino N, Suemune K,

Nishio M, Shigeoka M and Yokozaki H: ANAX10 induction

by interaction with tumor‑associated macrophages the growth

of esophageal squamous cell carcinoma. Pathol Int 69: 135‑147,

2019.

10. Shimizu T, Kasamatsu A, Yamamoto A, Koike K, Ishige S,

Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H and

Uzawa K: Annexin A10 in human oral cancer: Biomarker for

tumoral growth via G1/S transition by targeting MAPK signaling

pathways. PLoS One 7: e45510, 2012.

11. Masaki T, Tokuda M, Ohnishi M, Watanabe S, Fujimura T,

Miyamoto K, Itano T, Matsui H, Arima K, Shirai M, et al:

Enhanced expression of the protein kinase substrate annexin in

human hepatocellular carcinoma. Hepatology 24: 72‑81, 1996.

12. Kim JH, Rhee YY, Kim KJ, Cho NY, Lee HS and Kang GH:

Annexin A10 expression correlates with serrated pathway

features in colorectal carcinoma with microsatellite instability.

APMIS 122: 1187‑1195, 2014.

13. Tsai JH, Lin YL, Cheng YC, Chen CC, Lin LI, Tseng LH,

Cheng ML, Liau JY and Jeng YM: Aberrant expression of

annexin A10 is closely related to gastric phenotype in serrated

pathway to colorectal carcinoma. Mod Pathol 28: 268‑278, 2015.

14. Gonzalo DH, Lai KK, Shadrach B, Goldblum JR, Bennett AE,

Downs‑Kelly E, Liu X, Henricks W, Patil DT, Carver P, et al:

Gene expression profiling of serrated polyps identifies

annexin A10 as a marker of a sessile serrated adenoma/polyp.

J Pathol 230: 420‑429, 2013.

15. Bartley AN, Thompson PA, Buckmeier JA, Kepler CY, Hsu CH,

Snyder MS, Lance P, Bhattacharyya A and Hamilton SR:

Expression of gastric pyloric mucin, MUC6, in colorectal

serrated polyps. Mod Pathol 23: 169‑176, 2010.

16. Gibson JA, Hahn HP, Shahsafaei A and Odze RD: MUC

expression in hyperplastic and serrated colonic polyps: Lack of

specificity of MUC6. Am J Surg Pathol 35: 742‑749, 2011.

17. Walsh MD, Clendenning M, Williamson E, Pearson SA, Walters RJ,

Nagler B, Packenas D, Win AK, Hopper JL, Jenkins MA, et al:

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins

in colorectal cancers and their association with the CpG island

methylator phenotype. Mod Pathol 26: 1642‑1656, 2013.

18. Kim J, Kim MA, Jee CD, Jung EJ and Kim WH: Reduced

expression and homozygous deletion of annexin A10 in gastric

carcinoma. Int J Cancer 125: 1842‑1850, 2009.

19. Kim JK, Kim PJ, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ,

Shan JM, Ping WY, Park WS, et al: Decreased expression of

Annexin A10 in gastric cancer and its overexpression in tumor

cell growth suppression. Oncol Rep 24: 607‑612, 2010.

20. Brooke NM, Garcia‑Fernàndez J and Holland PW: The ParaHox

gene cluster is an evolutionary sister of the Hox gene cluster.

Nature 392: 920‑922, 1998.

21. Koizumi M, Doi R, Toyoda E, Masui T, Tulachan SS,

Kawaguchi Y, Fujimoto K, Gittes GK and Imamura M: Increased

PDX‑1 expression is associated with outcome in patients with

pancreatic cancer. Surgery 134: 260‑266, 2003.

22. Ma J, Chen M, Wang J, Xia HH, Zhu S, Liang Y, Gu Q,

Qiao L, Dai Y, Zou B, et al: Pancreatic duodenal homeobox‑1

(PDX1) functions as a tumor suppressor in gastric cancer.

Carcinogenesis 29: 1327‑1333, 2008.

23. Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J,

Green ME, Sentani K, Yasui W, McMahon M, et al: BRAFV600E

cooperates with CDX2 inactivation to promote serrated colorectal

tumorigenesis. Elife 6: e20331, 2017.

24. Yanagihara K, Tanaka H, Takigahira M, Ino Y, Yamaguchi Y,

Toge T, Sugano K and Hirohashi S: Establishment of two cell

lines from human gastric scirrhous carcinoma that possess the

potential to metastasize spontaneously in nude mice. Cancer

Sci 95: 575‑582, 2004.

25. Yasui W, Ayhan A, Kitadai Y, Nishimura K, Yokozaki H,

Ito H and Tahara E: Increased expression of p34cdc2 and its

kinase activity in human gastric and colonic carcinomas. Int J

Cancer 53: 36‑41, 1993.

26. Sakamoto N, Naito Y, Oue N, Sentani K, Uraoka N, Oo HZ,

Yanagihara K, Aoyagi K, Sasaki H and Yasui W: MicroRNA‑148a

is downregulated in gastric cancer, targets MMP7, and indicates

tumor invasiveness and poor prognosis. Cancer Sci 105: 236‑243,

2014.

27. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X,

Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, et al: Functional

engraftment of colon epithelium expanded in vitro from a single

adult Lgr5+ stem cell. Nat Med 18: 618‑623, 2012.

28. Koo BK, Sasselli V and Clevers H: Retroviral gene expression

control in primary organoid cultures. Curr Protoc Stem Cell

Biol 27: Unit 5A.6, 2013.

29. Livak KJ and Schmittgen TD: Analysis of relative gene expres‑

sion data using real‑time quantitative PCR and the 2(‑Delta Delta

C(T)) method. Methods 25: 402‑408, 2001.

30. Kim TH and Shivdasani RA: Stomach development, stem cells

and disease. Development 143: 554‑565, 2016.

31. Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N,

Stange DE, van Es JH, Abo A, Kujala P, Peters PJ and

Clevers H: Single Lgr5 stem cells build crypt‑villus structures

in vitro without a mesenchymal niche. Nature 459: 262‑265, 2009.

32. Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K,

Ohta Y, Toshimitsu K, Nakazato Y, Kawasaki K, et al: A

colorectal tumor organoid library demonstrates progressive loss

of niche factor requirements during tumorigenesis. Cell Stem

Cell 18: 827‑838, 2016.

33. Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H,

Kujala P, Vries R, Peters PJ and Clevers H: In vitro expansion of

human gastric epithelial stem cells and their responses to bacte‑

rial infection. Gastroenterology 148: 126‑136.e126, 2015.

34. Cancer Genome Atlas Research Network: Comprehensive molec‑

ular characterization of gastric adenocarcinoma. Nature 513:

202‑209, 2014.

35. van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F,

Pronk A, van Houdt W, van Gorp J, Taylor‑Weiner A, Kester L, et al:

Prospective derivation of a living organoid biobank of colorectal

cancer patients. Cell 161: 933‑945, 2015.

...

参考文献をもっと見る