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大学・研究所にある論文を検索できる 「Myocardial Strain Derived from ＾<13>N-ammonia Positron Emission Tomography: Detection of Ischemia-Related Wall Motion Abnormality」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Myocardial Strain Derived from ＾<13>N-ammonia Positron Emission Tomography: Detection of Ischemia-Related Wall Motion Abnormality

Nagao, Michinobu 長尾, 充展 ナガオ, ミチノブ Kawakubo, Masateru 河窪, 正照 カワクボ, マサテル Yamamoto, Atsushi 山本, 篤志 ヤマモト, アツシ Nakao, Risako ナカオ, リサコ Matsuo, Yuka マツオ, ユウカ Fukushima, Kenji 福島, 賢慈 フクシマ, ケンジ Sakai, Akiko サカイ, アキコ Momose, Mitsuru モモセ, ミツル Sakai, Shuji 坂井, 修二 サカイ, シュウジ 九州大学

2022.10

概要

Background: Due to the limitation of spatial resolution, cardiac nuclear medicine images have not been applied to feature-tracking method to automatic extraction of myocardial contours. We have successfully applied the feature-tracking method to high-resolution cine ＾<13>N-ammonia positron emission tomography (PET) images to calculate the regional myocardial strains. Here, we investigate the potential of ＾<13>N-ammonia PET-derived strain to detect ischemia-related wall motion abnormality.
Methods: Data of adenosine-stress/rest ＾<13>N-ammonia PET for 95 coronary artery disease patients was retrospectively analyzed. Using an original algorithm dedicated to ＾<13>N-ammonia PET, the longitudinal strain (LS) corresponding to the three main coronary artery territories (RCA, LAD, and LCX) was calculated from semi-automatic endocardial contours extraction on cine ＾<13>N-ammonia PET images of the left ventricular long-axis. The presence of ischemia in three main territories was determined from rest and stress-perfusion images.
Results: In all three coronary territories, LS at stress was significantly smaller at rest in the ischemic region RCA: -19.2±8.0% vs. -22.7±6.1%, LAD: -19.0±6.9% vs. -24.4±6.4%, LCX: -20.5%±7.6% vs. -22.6±6.9%). In contrast, in the non-ischemic region, there was no significant difference between the LS at stress and at rest. Receiver-operating-characteristic analysis revealed that using the optimal cutoff of the LS ratio of stress to rest, ischemia could be diagnosed with area under the curve of 0.82 in the RCA, 0.86 in the LAD, and 0.69 in the LCX.
Conclusions: Myocardial strain derived from endocardial feature-tracking of ＾<13>N-ammonia PET cine imaging is reduced in the ischemia induced by adenosine-stress. The LS ratio of stress to rest may detect wall motion abnormality related to ischemia.

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参考文献

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