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Creation of supramolecular biomembrane by the bottom-up self-assembly: Where material science meets biophysics

Yasuhara, Kazuma Morigaki, Kenichi 神戸大学

2022

概要

The biological membrane consisting of lipid bilayer and associated proteins possesses unique material properties that are critical to the membrane-based biological functions such as signal transduction and energy conversion [1]. The lipid bilayer is a two-dimensional fluid, in which membrane-associated molecules can laterally diffuse and interact with each other. The lipid membrane also acts as a permeation barrier towards water-soluble molecules, forming microscopic / nanoscopic compartments. These unique physicochemical properties of the biological membrane have important implications in material science, and fostered the development of biomimetic materials and systems. On the other hand, novel synthetic materials have a potential to be utilized in the fundamental studies of membrane biophysics. Bottom-up approaches based on the self-assembly of materials are promising to reproduce unique membrane structures and functions, providing insight into the machinery of the biological membrane and enabling a wide range of applications. In this article, we briefly introduce some recent studies to create novel artificial biomembranes using not only conventional phospholipids but also synthetic polymers, nanoparticles, and their hybrids to explore the interface between biophysics and material science. These topics are featured in the corresponding symposium in the 60th Annual Meeting of the Biophysical Society of Japan in 2022 where Drs. Morigaki, Sugihara, Tero, Fijii, Yusa, Yasuhara, and Mr. Masuda delivered invited lectures.

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