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大学・研究所にある論文を検索できる 「In vitro efficacy of 5-aminolevulic acid against Babesia gibsoni by solo-use and combined use with atovaquone」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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In vitro efficacy of 5-aminolevulic acid against Babesia gibsoni by solo-use and combined use with atovaquone

Iguchi, Aiko Iwatani, Nao Sakai, Aki 北海道大学

2022.02

概要

Babesia gibsoni is a tick-borne parasite of dogs. Atovaquone (ATV) is used to treat B. gibsoni infections, but recurrent with a single-nucleotide polymorphism (M121I) is a serious concern. The present study aimed to evaluate the effect of 5-aminolevulinic acid (5-ALA) on inhibiting in vitro growth of B. gibsoni and to evaluate the effect of combined use of ATV and 5-ALA on suppressing in vitro growth and regrowth. The growth of B. gibsoni was suppressed by nearly 85% with 1250 µM 5-ALA. Although the growth of B. gibsoni was suppressed after the combined exposure, the regrowth was observed. M121I was not detected in the regrowth population. 5-ALA might be useful in preventing the development of refractory canine babesiosis due to ATV.

参考文献

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