Arai E, Ushijima S, Gotoh M et al (2009) Genome-wide DNA meth- ylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma. Int J Cancer 125:2854–2862
Arai E, Chiku S, Mori T et al (2012) Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. Carcino- genesis 33:1487–1493
Baylin SB, Jones PA (2016) Epigenetic determinants of cancer. Cold Spring Harb Perspect Biol 8:a019505
Bibikova M, Le J, Barnes B, Saedinia-Melnyk S et al (2009) Genome- wide DNA methylation profiling using Infinium(R) assay. Epig- enomics 1:177–200
Brierley JD, Gospodarowicz MK, Wittekind C (2017) Stomach. TNM Classification of Malignant Tumours, 8th edn. Wiley-Blackwell Press, Hoboken, pp 93–95
Conroy T, Hammel P, Hebbar M et al (2018) FOLFIRINOX or gem- citabine as adjuvant therapy for pancreatic cancer. New Eng J Med 379:2395–2406
Egawa S, Toma H, Ohigashi H et al (2012) Japan pancreatic cancer registry; 30th year anniversary: Japan Pancreas Society. Pancreas 41:985–992
Fan S, Zhao C, Zhang L et al (2015) Knockdown of PFTK1 inhibits the migration of glioma cells. J Mol Neurosci 57:257–264
Fujimoto M, Arai E, Tsumura K et al (2020) Establishment of diag- nostic criteria for upper urinary tract urothelial carcinoma based on genome-wide DNA methylation analysis. Epigenetics 4:1–13
Gotoh M, Arai E, Wakai-Ushijima S et al. (2011) Diagnosis and prog- nostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial arti- ficial chromosome array-based methylated CpG island ampli- fication. J Biomed Biotechnol 2011;2011:780836. https://doi. org/10.1155/2011/780836
Groot VP, Rezaee N, Wu W et al (2018) Patterns, timing, and predic- tors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg 267:936–945
Groot VP, Gemenetzis G, Blair AB et al (2019) Defining and predicting early recurrence in 957 patients with resected pancreatic ductal adenocarcinoma. Ann Surg 269:1154–1162
Hassan MM, Bondy ML, Wolff RA et al (2007) Risk factors for pancreatic cancer: case-control study. Am J Gastroenterol 102:2696–2707
Hruban RH, Maitra A, Kern SE et al (1997) Precursors to pancreatic cancer. Gastroenterol Clin North Am 36:831–849
Hruban RH, Boffetta P, Hiraoka N et al (2019) Tumours of the pan- creas. WHO Classification of Tumours of Digestive System Tumours, 5th edn. IARC Press, Lyon, pp 279–337
Imawari Y, Mimoto R, Hirooka S et al (2018) Downregulation of dual- specificity tyrosine-regulated kinase 2 promotes tumor cell pro- liferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer. Cancer Sci 109:363–372
Johnstone SE, Reyes A, Qi Y et al (2020) Large-scale topological changes restrain malignant progression in colorectal cancer. Cell 182:1474–1489
Jones PA, Issa JP, Baylin S (2016) Targeting the cancer epigenome for therapy. Nat Rev Genet 17:630–641
Kanai Y, Nishihara H, Miyagi Y et al (2018) The Japanese Society of Pathology Guidelines on the handling of pathological tissue sam- ples for genomic research: standard operating procedures based on empirical analyses. Pathol Int 68:63–90
Kim J, Bretz CL, Lee S (2015) Epigenetic instability of imprinted genes in human cancers. Nucleic Acids Res 43:10689–10699
Kurahara H, Maemura K, Mataki Y et al (2018) A therapeutic strat- egy for resectable pancreatic cancer based on risk factors of early recurrence. Pancreas 47:753–758
Kuramoto J, Arai E, Tian Y (2017) Genome-wide DNA methylation analysis during non-alcoholic steatohepatitis-related multistage hepatocarcinogenesis: comparison with hepatitis virus-related carcinogenesis. Carcinogenesis 38:261–270
Liu Y, Gu Y, Su M et al (2019) An analysis about heterogeneity among cancers based on the DNA methylation patterns. BMC Cancer 19:1259
Makabe T, Arai E, Hirano T et al (2019) Genome-wide DNA methyla- tion profile of early-onset endometrial cancer: its correlation with genetic aberrations and comparison with late-onset endometrial cancer. Carcinogenesis 40:611–623
Matsumoto I, Murakami Y, Shinzeki M et al (2015) Proposed preop- erative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after surgical resection: a multi- center retrospective study. Pancreatology 15:674–680
Mishra SR, Mahapatra KK, Behera BR et al. (2020) Inflammasomes in cancer: Effect of epigenetic and autophagic modulations. Semin Cancer Biol 9:S1044–579X(20)30205–4.
Motoi F, Satoi S, Honda G et al (2019) A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study. J Gastroenterol 54:194–203
Murphy JE, Wo JY, Ryan DP et al (2018) Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiother- apy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial. JAMA Oncol 4:963–969
Nagashio R, Arai E, Ojima H et al (2011) Carcinogenetic risk estima- tion based on quantification of DNA methylation levels in liver tissue at the precancerous stage. Int J Cancer 129:1170–1179
Neoptolemos JP, Palmer DH, Ghaneh P et al (2017) Comparison of adjuvant gemcitabine and capecitabine with gemcitabine mono- therapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet 389:1011–1024
Nishio K, Kimura K, Amano R et al (2017) Preoperative predictors for early recurrence of resectable pancreatic cancer. World J Surg Oncol 15:16
Nones K, Waddell N, Song S et al (2014) Genome-wide DNA meth- ylation patterns in pancreatic ductal adenocarcinoma reveal epi- genetic deregulation of SLIT-ROBO, ITGA2 and MET signal- ing. Int J Cancer 135:1110–1118
Ohara K, Arai E, Takahashi Y et al (2017) Genes involved in devel- opment and differentiation are commonly methylated in can- cers derived from multiple organs: a single-institutional meth- ylome analysis using 1007 tissue specimens. Carcinogenesis 38:241–251
Ou-Yang J, Huang LH, Sun XX (2017) Cyclin-dependent kinase 14 promotes cell proliferation, migration and invasion in ovarian can- cer by inhibiting Wnt signaling pathway. Gynecol Obstet Invest 82:230–239
Peng DF, Kanai Y, Sawada M et al (2005) Increased DNA methyltrans- ferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci 96:403–408
Peng DF, Kanai Y, Sawada M et al (2006) DNA methylation of mul- tiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcino- genesis of the pancreas. Carcinogenesis 27:1160–1168
Sato T, Arai E, Kohno T et al (2014) Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. Int J Cancer 135:319–334
Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30
Sinn M, Bahra M, Liersch T et al (2017) CONKO-005: Adjuvant chem- otherapy with gemcitabine plus erlotinib versus gemcitabine alone in patients after R0 resection of pancreatic cancer: a multicenter randomized phase III trial. J Clin Oncol 35:3330–3337
Sugiura T, Uesaka K, Kanemoto H et al (2012) Serum CA19-9 is a sig- nificant predictor among preoperative parameters for early recur- rence after resection of pancreatic adenocarcinoma. J Gastrointest Surg 16:977–985
Tsumura K, Arai E, Tian Y et al (2019) Establishment of permutation for cancer risk estimation in the urothelium based on genome- wide DNA methylation analysis. Carcinogenesis 40:1308–1319
Tu J, Zhao Z, Xu M et al (2019) LINC00707 contributes to hepatocel- lular carcinoma progression via sponging miR-206 to increase CDK14. J Cell Physiol 234:10615–10624
Uesaka K, Boku N, Fukutomi A et al (2016) Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet 388:248–257
Wen X, Jeong S, Kim Y et al (2017) Improved results of LINE-1 meth- ylation analysis in formalin-fixed, paraffin- embedded tissues with the application of a heating step during the DNA extraction pro- cess. Clin Epigenetics 9:1
Yamanoi K, Arai E, Tian Y et al (2015) Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome. Carcinogenesis 36:509–520
Yokoyama T, Miura F, Araki H et al (2015) Changepoint detection in base-resolution methylome data reveals a robust signature of methylated domain landscape. BMC Genomics 16:594
Yotani T, Yamada Y, Arai E et al (2018) Novel method for DNA meth- ylation analysis using high-performance liquid chromatography and its clinical application. Cancer Sci 109:1690–1700
Yuan YH, Zhou J, Zhang Y et al (2019) Identification of key genes and pathways downstream of the β-catenin-TCF7L1 complex in pancreatic cancer cells using bioinformatics analysis. Oncol Lett 18:1117–1132
Zhang J, Shi K, Huang W et al (2019) The DNA methylation profile of non-coding RNAs improves prognosis prediction for pancreatic adenocarcinoma. Cancer Cell Int 19:107