[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
[9]
[10]
[11]
[12]
[13]
E. A. Bassett and V. A. Wallace, Cell fate determination in the ertebrate retina,
Trends in Neurosciences, vol. 35, no. 9, pp. 565 573, 2012.
L. Centanin and J. Wittbrodt, Retinal ne rogenesis, Development (Cambridge),
vol. 141, no. 2, pp. 241 244, 2014.
R. Marg eron and D. Reinberg, The Pol comb comple PRC2 and its mark in life,
Nature, vol. 469, no. 7330, pp. 343 349, 2011.
C. Cepko, Intrinsicall different retinal progenitor cells prod ce specific t pes of
progen , Nature Reviews Neuroscience, vol. 15, no. 9, pp. 615 627, 2014.
B. S. Clark, G. L. Stein-O Brien, F. Shia , G. H. Cannon, E. Da is-Marcisak, T.
Sherman, C. P. Santiago, T. V. Hoang, F. Rajaii, R. E. James-Esposito, R. M.
Gronostajski, E. J. Fertig, L. A. Goff, and S. Blacksha , Single-Cell RNA-Seq
Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit
and Late-Born Cell Specification, Neuron, vol. 102, no. 6, pp. 1111-1126.e5, 2019.
D. M. Davis and M. A. Dyer, Retinal progenitor cells, differentiation, and barriers
to cell cycle reentry, Current Topics in Developmental Biology, vol. 93, no. C, pp.
175-188, 2010.
M. Xiang, Intrinsic control of mammalian retinogenesis, Cellular and Molecular
Life Sciences, vol. 70, no. 14. pp. 2519 2532, 2013.
A. S aroop, D. Kim, and D. Forrest, Transcriptional reg lation of photoreceptor
de elopment and homeostasis in the mammalian retina, Nature Reviews
Neuroscience, vol. 11, no. 8, pp. 563 576, 2010.
T. J. Cherry, J. M. Trimarchi, M. B. Stadler, and C. L. Cepko, De elopment and
di ersification of retinal amacrine interne rons at single cell resol tion,
Proceedings of the National Academy of Sciences of the United States of America,
vol. 106, no. 23, pp. 9495 9500, 2009.
E. M. Morro , C. M. A. Chen, and C. L. Cepko, Temporal order of bipolar cell
genesis in the ne ral retina, Neural Development, vol. 3, no. 1, p. 2, 2008.
J. A. Br e inski, L. Praso , and T. Glaser, Math5 defines the ganglion cell
competence state in a s bpop lation of retinal progenitor cells e iting the cell c cle,
Developmental Biology, vol. 365, no. 2, pp. 395 413, 2012.
B. P. Hafler, N. Surzenko, K. T. Beier, C. Punzo, J. M. Trimarchi, J. H. Kong, and
C. L. Cepko, Transcription factor Olig2 defines subpopulations of retinal progenitor
cells biased to ard specific cell fates, Proceedings of the National Academy of
Sciences of the United States of America, vol. 109, no. 20, pp. 7882 7887, 2012.
S. Blackshaw, S. Harpavat, J. Trimarchi, L. Cai, H. Huang, W. P. Kuo, G. Weber, K.
Lee, R. E. Fraioli, S.-H. Cho, R. Yung, E. Asch, L. Ohno-Machado, W. H. Wong,
and C. L. Cepko, Genomic Anal sis of Mo se Retinal De elopment, PLoS
Biology, vol. 2, no. 9, p. e247, 2004.
49
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]
[25]
[26]
[27]
[28]
C. Dupont, D. R. Armant, and C. A. Brenner, Epigenetics: Definition, mechanisms
and clinical perspecti e, Seminars in Reproductive Medicine, vol. 27, no. 5, pp.
351 357, 2009.
T. S gan ma and J. L. Workman, Signals and Combinatorial F nctions of Histone
Modifications, Annual Review of Biochemistry, vol. 80, pp. 473 499, 2011.
R. Straussman, D. Nejman, D. Roberts, I. Steinfeld, B. Blum, N. Benvenisty, I.
Simon, Z. Yakhini, and H. Cedar, De elopmental programming of CpG island
methylation profiles in the human genome, Nature Structural and Molecular
Biology, vol. 16, no. 5, pp. 564 571, 2009.
M. Esteller, Cancer epigenomics: DNA meth lomes and histone-modification
maps, Nature Reviews Genetics, vol. 8, no. 4 pp. 286 298, 2007.
M. Esteller, Epigenetic gene silencing in cancer: The DNA h permeth lome,
Human Molecular Genetics, vol. 16, no. R1, pp. R50 R59, 2007.
R. K. Tittle, R. Sze, A. Ng, R. J. Nuckels, M. E. Swartz, R. M. Anderson, J. Bosch,
D. Y. R. Stainier, J. K. Eberhart, and J. M. Gross, Uhrf1 and Dnmt1 are req ired for
de elopment and maintenance of the ebrafish lens, Developmental Biology, vol.
350, no. 1, pp. 50 63, 2011.
M. Bostick, K. K. Jong, P. O. Estève, A. Clark, S. Pradhan, and S. E. Jacobsen,
UHRF1 pla s a role in maintaining DNA meth lation in mammalian cells,
Science, vol. 317, no. 5845, pp. 1760 1764, 2007.
C. Bronner, G. Fuhrmann, F. L. Chédin, M. Macaluso, and S. Dhe-Paganon,
UHRF1 links the histone code and DNA meth lation to ens re faithf l epigenetic
memor inheritance, Genetics and Epigenetics, vol. 2009, no. 2, pp. 29 36, 2009.
C. M. Ri era and B. Ren, Mapping h man epigenomes, Cell, vol. 155, no. 1, pp.
39 55, 2013.
D. H ertas, R. Sendra, and P. M o , Chromatin d namics co pled to DNA
repair, Epigenetics, vol. 4, no. 1, pp. 31 42, 2009.
T. Ko arides, Chromatin Modifications and Their F nction, Cell, vol. 128, no. 4,
pp. 693 705, 2007.
A. Jambhekar, A. Dhall, and Y. Shi, Roles and reg lation of histone meth lation in
animal de elopment, Nature Reviews Molecular Cell Biology, vol. 20, no. 10, pp.
625 641, 2019.
B. Li, M. Carey, and J. L. Workman, The Role of Chromatin d ring Transcription,
Cell, vol. 128, no. 4. Cell, pp. 707 719, 2007.
R. Karli , H. R. Ch ng, J. Lasserre, K. Vlaho i ek, and M. Vingron, Histone
modification le els are predicti e for gene e pression, Proceedings of the National
Academy of Sciences of the United States of America, vol. 107, no. 7, pp. 2926
2931, 2010.
A. J. R thenb rg, C. D. Allis, and J. W socka, Meth lation of L sine 4 on Histone
H3: Intricac of Writing and Reading a Single Epigenetic Mark, Molecular Cell,
vol. 25, no. 1, pp. 15 30, 2007.
50
[29]
[30]
[31]
[32]
[33]
[34]
[35]
[36]
[37]
[38]
[39]
[40]
[41]
Y. B. Sch art and V. Pirrotta, Pol comb silencing mechanisms and the
management of genomic programmes, Nature Reviews Genetics, vol. 8, no. 1, pp.
9 22, 2007.
L. Simó-Riudalbas and M. Esteller, Targeting the histone orthograph of cancer:
dr gs for riters, erasers and readers, British Journal of Pharmacology, vol. 172,
no. 11, pp. 2716 2732, 2015.
C. N. Vallianatos and S. I ase, Disr pted intricac of histone H3K4 meth lation in
neurodevelopmental disorders, Epigenomics, vol. 7, no. 3, pp. 503 518, 2015.
S. K. T. Ooi, C. Qiu, E. Bernstein, K. Li, D. Jia, Z. Yang, H. Erdjument-Bromage, P.
Tempst, S.-P. Lin, C. D. Allis, X. Cheng, and T. H. Bestor, DNMT3L connects
unmethylated lysine 4 of histone H3 to de no o meth lation of DNA, Nature, vol.
448, no. 7154, pp. 714 717, 2007.
M. Tachibana, Y. Mats m ra, M. F k da, H. Kim ra, and Y. Shinkai, G9a/GLP
complexes independently mediate H3K9 and DNA methylation to silence
transcription, EMBO Journal, vol. 27, no. 20, pp. 2681 2690, 2008.
J. P. Thomson, P. J. Skene, J. Selfridge, T. Clouaire, J. Guy, S. Webb, A. R. W.
Kerr, A. Deaton, R. Andrews, K. D. James, D. J. Turner, R. Illingworth, and A. Bird,
CpG islands infl ence chromatin str ct re ia the CpG-binding protein Cfp1,
Nature, vol. 464, no. 7291, pp. 1082 1086, 2010.
K. Y. Kim, Y. Tanaka, J. Su, B. Cakir, Y. Xiang, B. Patterson, J. Ding, Y. W. Jung,
J. J. H. Kim, E. Hysolli, H. Lee, R. Dajani, J. J. H. Kim, M. Zhong, J. H. Lee, D.
Skalnik, J. M. Lim, G. J. Sullivan, J. Wang, and I. H. Park, Uhrf1 reg lates acti e
transcriptional marks at bi alent domains in pl ripotent stem cells thro gh Setd1a,
Nature Communications, vol. 9, no. 1, p. 2583, 2018.
X. Corso-D a , C. Jaeger, V. Chaitankar, and A. S aroop, Epigenetic control of
gene reg lation d ring de elopment and disease: A ie from the retina, Progress
in Retinal and Eye Research, vol. 65, pp. 1 27, 2018.
L. Zelinger and A. S aroop, RNA Biolog in Retinal De elopment and Disease,
Trends in Genetics, vol. 34, no. 5, pp. 341 351, 2018.
T. I aga a and S. Watanabe, Molec lar mechanisms of H3K27me3 and H3K4me3
in retinal de elopment, Neuroscience research, vol. 138, pp. 43 48, 2018.
A. Iida, T. Iwagawa, Y. Baba, S. Satoh, Y. Mochizukil, H. Nakauchi, T. Furukawa,
H. Koseki, A. M rakami, and S. Watanabe, Roles of histone H3K27 trimeth lase
E h2 in retinal proliferation and differentiation, Developmental Neurobiology, vol.
75, no. 9, pp. 947 960, 2015.
D. Umutoni, T. Iwagawa, Y. Baba, A. Tsuhako, H. Honda, M. Aihara, and S.
Watanabe, H3K27me3 demeth lase UTX reg lates the differentiation of a s bset of
bipolar cells in the mo se retina, Genes to Cells, vol. 25, no. 6, pp. 402 412, 2020.
E. Shen, H. Sh lha, Z. Weng, and S. Akbarian, Reg lation of histone H3K4
meth lation in brain de elopment and disease, Philosophical Transactions of the
Royal Society B: Biological Sciences, vol. 369, no. 1652, 2014.
51
[42]
[43]
[44]
[45]
[46]
[47]
[48]
[49]
[50]
[51]
[52]
H. Hao, D. S. Kim, B. Klocke, K. R. Johnson, K. Cui, N. Gotoh, C. Zang, J.
Gregorski, L. Gieser, W. Peng, Y. Fann, M. Seifert, K. Zhao, and A. Swaroop,
Transcriptional reg lation of rod photoreceptor homeostasis re ealed b in i o
NRL targetome anal sis, PLoS Genetics, vol. 8, no. 4, 2012.
K. Ueno, T. Iwagawa, H. Kuribayashi, Y. Baba, H. Nakauchi, A. Murakami, M.
Nagasaki, Y. S ki, and S. Watanabe, Transition of differential histone H3
methylation in photoreceptors and other retinal cells d ring retinal differentiation,
Scientific Reports, vol. 6, p. 29264, 2016.
A. Shilatifard, The COMPASS famil of histone H3K4 meth lases: Mechanisms of
reg lation in de elopment and disease pathogenesis, Annual Review of
Biochemistry, vol. 81, pp. 65 95, 2012.
J. R. Da ie, W. X , and G. P. Delc e, Histone H3K4 trimeth lation: D namic
interplay with pre-mRNA splicing1, Biochemistry and Cell Biology, vol. 94, no. 1,
pp. 1 11, 2015.
Q. Qu, Y. hei Takahashi, Y. Yang, H. Hu, Y. Zhang, J. S. Brunzelle, J. F. Couture,
A. Shilatifard, and G. Skiniotis, Str ct re and Conformational D namics of a
COMPASS Histone H3K4 Meth ltransferase Comple , Cell, vol. 174, no. 5, pp.
1117-1126.e12, 2018.
N. T. Cr mp and T. A. Milne, Wh are so many MLL lysine methyltransferases
req ired for normal mammalian de elopment?, Cellular and Molecular Life
Sciences, vol. 76, no. 15, pp. 2885 2898, 2019.
A. Kran and K. Anastassiadis, The role of SETD1A and SETD1B in de elopment
and disease, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol.
1863, no. 8, p. 194578, 2020.
A. S. Bledau, K. Schmidt, K. Neumann, U. Hill, G. Ciotta, A. Gupta, D. C. Torres, J.
F , A. Kran , A. F. Ste art, and K. Anastassiadis, The H3K4 meth ltransferase
Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after
gastr lation, Development (Cambridge), vol. 141, no. 5, pp. 1022 1035, 2014.
M. R. Higgs, K. Sato, J. J. Reynolds, S. Begum, R. Bayley, A. Goula, A. Vernet, K.
L. Paquin, D. G. Skalnik, W. Kobayashi, M. Takata, N. G. Howlett, H. Kurumizaka,
H. Kim ra, and G. S. Ste art, Histone Meth lation b SETD1A Protects Nascent
DNA thro gh the N cleosome Chaperone Acti it of FANCD2, Molecular Cell,
vol. 71, no. 1, pp. 25-41.e6, 2018.
K. Tajima, S. Matsuda, T. Yae, B. J. Drapkin, R. Morris, M. Boukhali, K.
Niederhoffer, V. Comaills, T. Dubash, L. Nieman, H. Guo, N. K. C. Magnus, N.
D son, T. Shioda, W. Haas, D. A. Haber, and S. Mahes aran, SETD1A protects
from senescence thro gh reg lation of the mitotic gene e pression program, Nature
Communications, vol. 10, no. 1, pp. 1 13, 2019.
T. Hoshii, P. Cifani, Z. Feng, C. H. Huang, R. Koche, C. W. Chen, C. D. Delaney, S.
W. Lo e, A. Kentsis, and S. A. Armstrong, A Non-catalytic Function of SETD1A
Reg lates C clin K and the DNA Damage Response, Cell, vol. 172, no. 5, pp.
1007-1021.e17, 2018.
52
[53]
[54]
[55]
[56]
[57]
[58]
[59]
[60]
[61]
[62]
[63]
J. Mukai, E. Cannavò, G. W. Crabtree, Z. Sun, A. Diamantopoulou, P. Thakur, C. Y.
Chang, Y. Cai, S. Lom ardas, A. Takata, B. X , and J. A. Gogos, Recapit lation
and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice,
Neuron, vol. 104, no. 3, pp. 471-487.e12, 2019.
A. Takata, B. Xu, I. Ionita-Laza, J. L. Roos, J. A. Gogos, and M. Karayiorgou,
Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate
S sceptibilit Gene, Neuron, vol. 82, no. 4, pp. 773 780, 2014.
T. Singh, M. I. Kurki, D. Curtis, S. M. Purcell, L. Crooks, J. McRae, J. Suvisaari, H.
Chheda, D. Blackwood, G. Breen, O. Pietilinen, S. S. Gerety, M. Ayub, M. Blyth, T.
Cole, D. Collier, E. L. Coomber, N. Craddock, M. J. Daly, J. Danesh, J. C. Barrett,
Rare loss-of-function variants in SETD1A are associated with schizophrenia and
de elopmental disorders, Nature Neuroscience, vol. 19, no. 4, pp. 571 577, 2016.
A. Takata, B. Xu, I. Ionita-Laza, J. L. Roos, J. A. Gogos, and M. Karayiorgou,
Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate
S sceptibilit Gene, Neuron, vol. 82, no. 4, pp. 773 780, 2014.
K. Nagahama, K. Sakoori, T. Watanabe, Y. Kishi, K. Kawaji, and M. Koebis,
Article Setd1a Ins fficienc in Mice Attenuates Excitatory Synaptic Function and
Recapitulates Schizophrenia- Related Behavioral Abnormalities ll Setd1a
Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates
Schizophrenia-Related , Cell Reports, vol. 32, no. 11, p. 108126, 2020.
S. Satoh, K. Tang, A. Iida, M. Inoue, T. Kodama, S. Y. Tsai, M. J. Tsai, Y. Furuta,
and S. Watanabe, The spatial patterning of mo se cone opsin e pression is
regulated by bone morphogenetic protein signaling through downstream effector
COUP-TF n clear receptors, Journal of Neuroscience, vol. 29, no. 40, pp. 12401
12411, 2009.
Y. Tabata, Y. Ouchi, H. Kamiya, T. Manabe, K. Arai, and S. Watanabe,
Specification of the Retinal Fate of Mo se Embr onic Stem Cells b Ectopic
Expression of R /ra , a Homeobo Gene, Molecular and Cellular Biology, vol. 24,
no. 10, pp. 4513 4521, 2004.
A. Iida, T. Shinoe, Y. Baba, H. Mano, S. Watanabe, Y. Tabata, Y. Ouchi, H.
Kami a, T. Manabe, K. Arai, and S. Watanabe, Dicer pla s essential roles for
retinal de elopment b reg lation of s r i al and differentiation, Investigative
Ophthalmology and Visual Science, vol. 52, no. 10, pp. 4513 4521, 2004.
T. Shinoe, H. Kuribayashi, H. Saya, M. Seiki, H. Aburatani, and S. Watanabe,
Identification of CD44 as a cell s rface marker for M ller glia prec rsor cells,
Journal of Neurochemistry, vol. 115, no. 6, pp. 1633 1642, 2010.
R. Patro, G. D ggal, M. I. Lo e, R. A. Iri arr , and C. Kingsford, Salmon pro ides
fast and bias-aware quantification of transcript e pression, Nature Methods, vol. 14,
no. 4, pp. 417 419, 2017.
N. L. Bra , H. Pimentel, P. Melsted, and L. Pachter, Near-optimal probabilistic
RNA-seq q antification, Nature Biotechnology, vol. 34, no. 5, pp. 525 527, 2016.
53
[64]
[65]
[66]
[67]
[68]
[69]
[70]
[71]
[72]
[73]
[74]
D. W. H ang, B. T. Sherman, and R. A. Lempicki, S stematic and integrati e
anal sis of large gene lists sing DAVID bioinformatics reso rces, Nature
Protocols, vol. 4, no. 1, pp. 44 57, 2009.
D. W. H ang, B. T. Sherman, and R. A. Lempicki, Bioinformatics enrichment
tools: Paths to ard the comprehensi e f nctional anal sis of large gene lists,
Nucleic Acids Research, vol. 37, no. 1, pp. 1 13, 2009.
A. Iida, T. Iwagawa, H. Kuribayashi, S. Satoh, Y. Mochizuki, Y. Baba, H. Nakauchi,
T. Furukawa, H. Koseki, A. M rakami, and S. Watanabe, Histone demeth lase
Jmjd3 is req ired for the de elopment of s bsets of retinal bipolar cells,
Proceedings of the National Academy of Sciences of the United States of America,
vol. 111, no. 10, pp. 3751 3756, 2014.
I. Aldiri, B. Xu, L. Wang, X. Chen, D. Hiler, L. Griffiths, M. Valentine, A.
Shirinifard, S. Thiagarajan, A. Sablauer, M. E. Barabas, J. Zhang, D. Johnson, S.
Frase, X. Zhou, J. Easton, J. Zhang, E. R. Mardis, R. K. Wilson, J. R. Downing, and
M. A. D er, The D namic Epigenetic Landscape of the Retina D ring
De elopment, Reprogramming, and T morigenesis, Neuron, vol. 94, no. 3, pp. 550568.e10, 2017.
B. Langmead and S. L. Sal berg, Fast gapped-read alignment ith Bo tie 2,
Nature Methods, vol. 9, no. 4, pp. 357 359, 2012.
H. Li, B. Handsaker, A. Wysoker, T. Fennell, J. Ruan, N. Homer, G. Marth, G.
Abecasis, and R. D rbin, The Seq ence Alignment/Map format and SAMtools,
Bioinformatics, vol. 25, no. 16, pp. 2078 2079, 2009.
H. Li, A statistical frame ork for SNP calling, m tation disco er , association
mapping and pop lation genetical parameter estimation from seq encing data,
Bioinformatics, vol. 27, no. 21, pp. 2987 2993, 2011.
Y. Zhang, T. Liu, C. A. Meyer, J. Eeckhoute, D. S. Johnson, B. E. Bernstein, C.
N ssba m, R. M. M ers, M. Bro n, W. Li, and X. S. Shirle , Model-based
analysis of ChIP-Seq (MACS), Genome Biology, vol. 9, no. 9, p. R137, 2008.
G. Y , L. G. Wang, and Q. Y. He, ChIP seeker: An R/Biocond ctor package for
ChIP peak annotation, comparison and is ali ation, Bioinformatics, vol. 31, no.
14, pp. 2382 2383, 2015.
S. B. Rothbart, K. Krajewski, N. Nady, W. Tempel, S. Xue, A. I. Badeaux, D.
Barsyte-Lovejoy, J. Y. Martinez, M. T. Bedford, S. M. Fuchs, C. H. Arrowsmith,
and B. D. Strahl, Association of UHRF1 ith meth lated H3K9 directs the
maintenance of DNA meth lation, Nature Structural and Molecular Biology, vol.
19, no. 11, pp. 1155 1160, 2012.
S. B. Rothbart, B. M. Dickson, M. S. Ong, K. Krajewski, S. Houliston, D. B. Kireev,
C. H. Arro smith, and B. D. Strahl, M lti alent histone engagement b the linked
tandem tudor and PHD domains of UHRF1 is required for the epigenetic inheritance
of DNA meth lation, Genes and Development, vol. 27, no. 11, pp. 1288 1298,
2013.
54
[75]
[76]
[77]
[78]
[79]
[80]
[81]
[82]
[83]
[84]
[85]
[86]
[87]
J. Y. Hahm, J. W. Park, J. Y. Kang, J. Park, C. H. Kim, J. Y. Kim, N. C. Ha, J. W.
Kim, and S. B. Seo, Acet lation of UHRF1 Reg lates Hemi-methylated DNA
Binding and Maintenance of Genome- ide DNA Meth lation, Cell Reports, vol.
32, no. 4, p. 107958, 2020.
K. J. Wahlin, R. A. Enke, J. A. Fuller, G. Kalesnykas, D. J. Zack, and S. L. Merbs,
Epigenetics and cell death: DNA h permeth lation in programmed retinal cell
death, PLoS ONE, vol. 8, no. 11, p. e79140, 2013.
M. S e and K. H. Sit, VAD-fmk and DEVD-cho induced late mitosis arrest and
apoptotic e pressions, Apoptosis, vol. 5, no. 1, pp. 29 36, 2000.
T. I aga a and S. Watanabe, Molec lar mechanisms of H3K27me3 and H3K4me3
in retinal de elopment, Neuroscience Research, vol. 138, pp. 43 48, 2019.
T. I aga a, H. Honda, and S. Watanabe, Jmjd3 pla s pi otal roles in the proper
development of early-born retinal lineages: Amacrine, horizontal, and retinal
ganglion cells, Investigative Ophthalmology and Visual Science, vol. 61, no. 11, pp.
43 43, 2020.
D. Umutoni, T. Iwagawa, Y. Baba, A. Tsuhako, H. Honda, M. Aihara, and S.
Watanabe, H3K27me3 demeth lase UTX reg lates the differentiation of a s bset of
bipolar cells in the mo se retina, Genes to Cells, vol. 25, no. 6, pp. 402 412, 2020.
C. Ki il aprak, D. Spehner, D. De s, and P. Sch lt , In Vi o chromatin
organi ation of mo se rod photoreceptors correlates ith histone modifications,
PLoS ONE, vol. 5, no. 6, p. e11039, 2010.
J. H. Lee and D. G. Skalnik, Rbm15-Mkl1 interacts with the Setd1b histone H3Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent
proliferation, PLoS ONE, vol. 7, no. 8, p. e42965, 2012.
R. K. Singh, R. K. Mallela, A. Hayes, N. R. Dunham, M. E. Hedden, R. A. Enke, R.
N. Fariss, H. Sternberg, M. D. West, and I. O. Nasonkin, Dnmt1, Dnmt3a and
Dnmt3b cooperate in photoreceptor and outer plexiform layer development in the
mammalian retina, Experimental Eye Research, vol. 159, pp. 132 146, 2017.
K. D. Rhee, J. Y , C. Y. Zhao, G. Fan, and X. J. Yang, Dnmt1-dependent DNA
methylation is essential for photoreceptor terminal differentiation and retinal neuron
s r i al, Cell Death and Disease, vol. 3, no. 11, p. e427, 2012.
G. Chen, Y. Luo, K. Warncke, Y. Sun, D. S. Yu, H. Fu, M. Behera, S. S.
Ramalingam, P. W. Doetsch, D. M. Duong, M. Lammers, W. J. Curran, and X.
Deng, Acet lation reg lates ribon cleotide red ctase acti it and cancer cell
gro th, Nature Communications, vol. 10, no. 1, pp. 1 16, 2019.
P. F. Liu, C. F. Chen, C. W. Shu, H. M. Chang, C. H. Lee, H. H. Liou, L. P. Ger, C.
L. Chen, and B. H. Kang, UBE2C is a Potential Biomarker for T morigenesis and
Prognosis in Tong e Sq amo s Cell Carcinoma, Diagnostics, vol. 10, no. 9, p. 674,
2020.
K. Zhang, W. Lin, J. A. Latham, G. M. Riefler, J. M. Schumacher, C. Chan, K.
Tatchell, D. H. Ha ke, R. Koba ashi, and S. Y. R. Dent, The Set1
55
[88]
[89]
[90]
[91]
methyltransferase opposes Ipl1 Aurora kinase functions in chromosome
segregation, Cell, vol. 122, no. 5, pp. 723 734, 2005.
D. R. Lorenz, I. V. Mikheyeva, P. Johansen, L. Meyer, A. Berg, S. I. S. Grewal, and
H. P. Cam, CENP-B Cooperates with Set1 in Bidirectional Transcriptional
Silencing and Genome Organization of Retrotransposons, Molecular and Cellular
Biology, vol. 32, no. 20, pp. 4215 4225, 2012.
M. H dl and K. Basler, Transcription in the absence of histone H3.2 and H3K4
meth lation, Current Biology, vol. 22, no. 23, pp. 2253 2257, 2012.
T. Clouaire, S. Webb, P. Skene, R. Illingworth, A. Kerr, R. Andrews, J. H. Lee, D.
Skalnik, and A. Bird, Cfp1 integrates both CpG content and gene acti it for
acc rate H3K4me3 deposition in embr onic stem cells, Genes and Development,
vol. 26, no. 15, pp. 1714 1728, 2012.
K. Arndt, A. Kranz, J. Fohgrub, A. Jolly, A. S. Bledau, M. Di Virgilio, M. Lesche,
A. Dahl, T. H fer, A. F. Ste art, and C. Wasko , SETD1A protects HSCs from
activation-ind ced f nctional decline in i o, Blood, vol. 131, no. 12, pp. 1311
1324, 2018.
56
Acknowledgements
Firstly, I would like to express my utmost appreciation to my supervisor Professor Sumiko
Watanabe for offering me an opportunity to undertake this PhD study and providing generous
supports. Without her complete trust and continuous encouragement, I would not be able to
commence this PhD program, let alone having such great scientific experience. Always and
forever, I will remember Sumiko sensei and our laboratory.
Secondly, I am sincerely grateful to my advisor
Dr. Toshiro Iwagawa for his perfect
scientific knowledge teaching, effective guidance, and invaluable inspiration throughout the
whole process, all of which are essential for the completion of this thesis and my PhD
program.
Thirdly, I would like to thank Professor Yutaka Suzuki and Dr. Masaya Fukushima for
their contribution to this thesis, and all the other lovely lab members for their always generous
help.
I would also like to acknowledge my country China and the China Scholarship Council
(CSC) for providing sufficient scholarship that supports my living here in Japan.
Last but by no means least, my heartfelt thanks go to my parents
Deng yuanwen and
Luo lin for their deep love and wholehearted support, which inspired me to pursue my ideal,
and to be a better person.
57
...
論文の公開元へ
