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大学・研究所にある論文を検索できる 「Dose–volume histogram analysis and clinical evaluation of knowledge-based plans with manual objective constraints for pharyngeal cancer」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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Dose–volume histogram analysis and clinical evaluation of knowledge-based plans with manual objective constraints for pharyngeal cancer

植原 拓也 近畿大学

2023.01.12

概要

The present study aimed to evaluate whether knowledge-based plans (KBP) from a single optimization could be used clinically, and to compare dose-volume histogram (DVH) parameters and plan quality between KBP with (KBPCONST) and without (KBPORIG) manual objective constraints and clinical manual optimized (CMO) plans for pharyngeal cancer. KBPs were produced from a system trained on clinical plans from 55 patients with pharyngeal cancer who had undergone intensity-modulated radiation therapy or volumetric-modulated arc therapy (VMAT). For another 15 patients, DVH parameters of KBPCONST ^nd KBPORIG from a single optimization were compared with CMO plans with respect to the planning target volume (D^-w, Dso%> 02%), brainstem maximum dose (Dmax), spina] cord Dmax, parotid gland median and mean dose (Dmvj and Dmcan), monitor units and modulation complexity score for VMAT. The Dmax of spinal cord and brainstem and the Dmci, and Dmean of ipsilateral parotid glands were unacceptably high for KBPQRJG, although the KBPCONST DVH parameters met our goal for most patients. KBPCONST and CiMO plans produced comparable DVH parameters. The monitor units of KBPCONST were significantly lower than those of the CMO plans (P < 0.001). Dose distribution of the KBPCONST was better than or comparable to that of the CMO plans for 13 (87%) of the 15 patients. In conclusion, KBPORIG was found to be clinically unacceptable, while KBPCONST from a single optimization was comparable or superior to CMO plans for most patients with head and neck cancer.

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