1. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A and
Roberts LR: A global view of hepatocellular carcinoma: Trends,
risk, prevention and management. Nat Rev Gastroenterol
Hepatol 16: 589‑604, 2019.
2. Wang CH, Wey KC, Mo LR, Chang KK, Lin RC and Kuo JJ:
Current trends and recent advances in diagnosis, therapy, and
prevention of hepatocellular carcinoma. Asian Pac J Cancer
Prev 16: 3595‑3604, 2015.
3. Sherman M: Hepatocellular carcinoma: Epidemiology,
surveillance, and diagnosis. Semin Liver Dis 30: 3‑16, 2010.
4. Iwama H, Masaki T and Kuriyama S: Abundance of microRNA
target motifs in the 3'‑UTRs of 20527 human genes. FEBS
Lett 581: 1805‑1810, 2007.
5. Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and
function. Cell 116: 281‑297, 2004.
6. Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ,
MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, et al:
Combinatorial microRNA target predictions. Nat Genet 37:
495‑500, 2005.
7. Bartel DP: Metazoan MicroRNAs. Cell 173: 20‑51, 2018.
8. Tomasello L, Cluts L and Croce CM: Experimental validation
of microRNA targets: Mutagenesis of binding regions. Methods
Mol Biol 1970: 331‑339, 2019.
9. Meng F, Henson R, Wehbe‑Janek H, Ghoshal K, Jacob ST
and Patel T: MicroRNA‑21 regulates expression of the PTEN
tumor suppressor gene in human hepatocellular cancer.
Gastroenterology 133: 647‑658, 2007.
10. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H,
Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, et al:
Reduced expression of the let‑7 microRNAs in human lung
cancers in association with shortened postoperative survival.
Cancer Res 64: 3753‑3756, 2004.
11. Varnholt H, Drebber U, Schulze F, Wedemeyer I, Schirmacher P,
Dienes HP and Odenthal M: MicroRNA gene expression profile
of hepatitis C virus‑associated hepatocellular carcinoma.
Hepatology 47: 1223‑1232, 2008.
12. Visone R and Croce CM: miRNAs and cancer. Am J Pathol 174:
1131‑1138, 2009.
13. Morishita A and Masaki T: miRNA in hepatocellular carcinoma.
Hepatol Res 45: 128‑141, 2015.
14. Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD,
Shimizu M, Cimmino A, Zupo S, Dono M, et al: MicroRNA
profiling reveals distinct signatures in B cell chronic lymphocytic
leukemias. Proc Natl Acad Sci USA 101: 11755‑11760, 2004.
15. Sevignani C, Calin GA, Siracusa LD and Croce CM: Mammalian
microRNAs: A small world for fine‑tuning gene expression.
Mamm Genome 17: 189‑202, 2006.
16. Metzler M, Wilda M, Busch K, Viehmann S and Borkhardt A:
High expression of precursor microRNA‑155/BIC RNA
in children with Burkitt lymphoma. Genes Chromosomes
Cancer 39: 167‑169, 2004.
17. Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP
and James RJ: Reduced accumulation of specific microRNAs in
colorectal neoplasia. Mol Cancer Res 1: 882‑891, 2003.
18. Tokarz P and Blasiak J: The role of microRNA in metastatic
colorectal cancer and its significance in cancer prognosis and
treatment. Acta Biochim Pol 59: 467‑474, 2012.
19. Del Vescovo V and Denti MA: microRNA and lung cancer. Adv
Exp Med Biol 889: 153‑177, 2015.
20. Yang X, Liang L, Zhang XF, Jia HL, Qin Y, Zhu XC, Gao XM,
Qiao P, Zheng Y, Sheng YY, et al: MicroRNA‑26a suppresses
tumor growth and metastasis of human hepatocellular carcinoma
by targeting interleukin‑6‑Stat3 pathway. Hepatology 58:
158‑170, 2013.
21. Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C and
Zhuang SM: MicroRNA‑26a/b and their host genes cooperate to
inhibit the G1/S transition by activating the pRb protein. Nucleic
Acids Res 40: 4615‑4625, 2012.
22. Wang Y, Lu Y, Toh ST, Sung WK, Tan P, Chow P, Chung AYF,
Jooi LLP and Lee CG: Lethal‑7 is down‑regulated by the
hepatitis B virus x protein and targets signal transducer and
activator of transcription 3. J Hepatol 53: 57‑66, 2010.
23. Wang Z, Lin S, Li JJ, Xu Z, Yao H, Zhu X, Xie D, Shen Z, Sze J,
Li K, et al: MYC protein inhibits transcription of the microRNA
cluster MC‑let‑7a‑1~let‑7d via noncanonical E‑box. J Biol
Chem 286: 39703‑39714, 2011.
24. Tsang WP and Kwok TT: Let‑7a microRNA suppresses
therapeutics‑induced cancer cell death by targeting caspase‑3.
Apoptosis 13: 1215‑1222, 2008.
25. Di Fazio P, Montalbano R, Neureiter D, Alinger B, Schmidt A,
Merkel AL, Quint K and Ocker M: Downregulation of HMGA2
by the pan‑deacetylase inhibitor panobinostat is dependent on
hsa‑let‑7b expression in liver cancer cell lines. Exp Cell Res 318:
1832‑1843, 2012.
NOMURA et al: ASSOCIATION BETWEEN miR‑527 AND GLYPICAN‑3 IN HEPATOCELLULAR CARCINOMA
26. Zhu XM, Wu LJ, Xu J, Yang R and Wu FS: Let‑7c microRNA
expression and clinical significance in hepatocellular carcinoma.
J Int Med Res 39: 2323‑2329, 2011.
27. Lan FF, Wang H, Chen YC, Chan CY, Ng SS, Li K, Xie D,
He ML, Lin MC and Kung HF: Hsa‑let‑7g inhibits proliferation
of hepatocellular carcinoma cells by downregulation of c‑Myc
and upregulation of p16(INK4A). Int J Cancer 128: 319‑331,
2011.
28. Traister A, Shi W and Filmus J: Mammalian Notum induces the
release of glypicans and other GPI‑anchored proteins from the
cell surface. Biochem J 410: 503‑511, 2008.
29. Li N, Gao W, Zhang YF and Ho M: Glypicans as Cancer
Therapeutic Targets. Trends Cancer 4: 741‑754, 2018.
30. Capurro MI, Xu P, Shi W, Li F, Jia A and Filmus J: Glypican‑3
inhibits Hedgehog signaling during development by competing
with patched for Hedgehog binding. Dev Cell 14: 700‑711,
2008.
31. Shirakawa H, Suzuki H, Shimomura M, Kojima M, Gotohda N,
Takahashi S, Nakagohri T, Konishi M, Kobayashi N,
Kinoshita T, et al: Glypican‑3 expression is correlated with poor
prognosis in hepatocellular carcinoma. Cancer Sci 100: 1403‑1407,
2009.
32. Zhang J, Zhang M, Ma H, Song X, He L, Ye X and Li X:
Overexpression of glypican‑3 is a predictor of poor prognosis in
hepatocellular carcinoma: An updated meta‑analysis. Medicine
(Baltimore) 97: e11130, 2018.
33. Fujihara S, Kato K, Morishita A, Iwama H, Nishioka T, Chiyo T,
Nishiyama N, Miyoshi H, Kobayashi M, Kobara H, et al:
Antidiabetic drug metformin inhibits esophageal adenocar‑
cinoma cell proliferation in vitro and in vivo. Int J Oncol 46:
2172‑2180, 2015.
34. Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J,
Katsura A, Tatsuta M, Maeda E, Mimura S, et al: Galectin‑9
suppresses the growth of hepatocellular carcinoma via apoptosis
in vitro and in vivo. Int J Oncol 46: 2419‑2430, 2015.
35. Bolstad BM, Irizarry RA, Astrand M and Speed TP: A comparison
of normalization methods for high density oligonucleotide array
data based on variance and bias. Bioinformatics 19: 185‑193,
2003.
36. Laemmli UK: Cleavage of structural proteins during the
assembly of the head of bacteriophage T4. Nature 227: 680‑685,
1970.
37. Towbin H, Staehelin T and Gordon J: Electrophoretic transfer
of proteins from polyacrylamide gels to nitrocellulose sheets:
Procedure and some applications. Proc Natl Acad Sci USA 76:
4350‑4354, 1979.
38. Benjamini Y and Hochberg Y: Controlling the false discovery
rate: A practical and powerful approach to multiple testing.
J R Stat Soc B 57: 289‑300, 1995.
39. Chen Y‑H, Song Y, Yu YL, Cheng W and Tong X: miRNA‑10a
promotes cancer cell proliferation in oral squamous cell
carcinoma by upregulating GLUT1 and promoting glucose
metabolism. Oncol Lett 17: 5441‑5446, 2019.
40. Pal R and Greene S: microRNA‑10b is overexpressed and critical
for cell survival and proliferation in medulloblastoma. PLoS
One 10: e0137845, 2015.
41. Werk AN, Bruckmueller H, Haenisch S and Cascorbi I: Genetic
variants may play an important role in mRNA‑miRNA inter‑
action: Evidence for haplotype‑dependent downregulation of
ABCC2 (MRP2) by miRNA‑379. Pharmacogenet Genomics 24:
283‑291, 2014.
42. Nishida T and Kataoka H: Glypican 3‑targeted therapy in hepa‑
tocellular carcinoma. Cancers (Basel) 11: E1339, 2019.
43. Vongchan P and Linhardt RJ: Characterization of a new mono‑
clonal anti‑glypican‑3 antibody specific to the hepatocellular
carcinoma cell line, HepG2. World J Hepatol 9: 368‑384, 2017.
44. Singh AK, Kumar R and Pandey AK: Hepatocellular Carcinoma:
Causes, Mechanism of Progression and Biomarkers. Curr Chem
Genomics Transl Med 12: 9‑26, 2018.
45. Zhou F, Shang W, Yu X and Tian J: Glypican‑3: A promising
biomarker for hepatocellular carcinoma diagnosis and treatment.
Med Res Rev 38: 741‑767, 2018.
46. Wang L, Yao M, Pan LH, Qian Q and Yao DF: Glypican‑3 is a
biomarker and a therapeutic target of hepatocellular carcinoma.
Hepatobiliary Pancreat Dis Int 14: 361‑366, 2015.
47. Lai JP, Sandhu DS, Yu C, Han T, Moser CD, Jackson KK,
Guerrero RB, Aderca I, Isomoto H, Garrity‑Park MM, et al:
Sulfatase 2 up‑regulates glypican 3, promotes fibroblast growth
factor signaling, and decreases survival in hepatocellular
carcinoma. Hepatology 47: 1211‑1222, 2008.
48. Huo W, Zhu XM, Pan XY, Du M, Sun Z and Li ZM: MicroRNA‑527
inhibits TGF‑β/SMAD induced epithelial‑mesenchymal tran‑
sition via downregulating SULF2 expression in non‑small‑cell
lung cancer. Math Biosci Eng 16: 4607‑4621, 2019.
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