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20
Tables
Table 1. Patient characteristics and clinical outcomes of the FIRS and non-FIRS groups
Characteristics
FIRS
Non-FIRS
p-value
Patients
36
93
N/A
Age (years)a
33
34
0.654
(22–45)
(18–47)
22.5
44.1
(20/36)
(41/93)
54.7
17.2
(11/36)
(16/93)
22.8
20.9
(16.4–43.9)
(15.2–38.6)
22.2
6.5
(8/36)
(6/93)
16.7
10.8
(6/36)
(10/93)
1.1
(0/36)
(1/93)
2.8
1.1
(1/36)
(1/93)
36.1
34.4
(13/36)
(32/93)
61.1
47.3
(22/36)
(44/93)
Primipara (%)b
IVF (%)b
BMI (kg/m2)a
GDM (%)b
HDP (%)b
Maternal fever (%)b
Fetal tachycardia (%)b
Spontaneous labor onset (%)b
CS (%)b
0.326
0.146
0.047
0.022
0.38
0.482
0.84
0.175
21
GA at delivery (weeks)a
Birth weight (g)a
Umbilical artery pHa
NICU admission (%)b
Neonatal jaundice (%)b
TTN (%)b
RDS (%)b
Respiratory support (%)b
IVH (%)b
ROP (%)b
38.4
38.3
(28.7–40.7)
(30.4–41.4)
3006
2854
(1360–3768)
(1324–3594)
7.302
7.302
(7.016–7.386)
(7.109–7.412)
27.8
26.9
(10/36)
(25/93)
13.9
9.7
(5/36)
(9/93)
8.3
11.8
(3/36)
(11/93)
2.8
1.1
(1/36)
(1/93)
16.7
12.9
(6/36)
(12/93)
2.3
(1/36)
(0/93)
2.3
(1/36)
(0/93)
The Mann–Whitney U-test was used for between-group comparisons, which are
presented as median (range).
0.282
0.343
0.795
0.533
0.756
0.482
0.58
0.279
0.279
22
Fisher’s exact test was used for between-group comparisons.†
FIRS, fetal inflammatory response syndrome; BMI, body mass index; GDM, gestational diabetes
mellitus; IVF, in vitro fertilization; CS, cesarean section; GA, gestational age; NICU, neonatal intensive
care unit; TTN, transient tachypnea of the newborn; RDS, respiratory distress syndrome; IVH,
intraventricular hemorrhage; ROP, retinopathy of prematurity.
23
Table 2. Maternal WBC and CRP levels and amniotic fluid IL-6, NGAL and L-FABP
levels in the FIRS and non-FIRS groups on univariate analysis
Data comparison
WBC (/μL)a
CRP (mg/dL)a
IL-6 (pg/mL)
NGAL
Total
(ng/mL)a
VD
CS
L-FABP (ng/ml)a
FIRS
Non-FIRS
(n=36)
(n=93)
9600
7950
(5200-22900)
(4600-19000)
0.22
0.23
(0.04–7.27)
(0.05–3.21)
22022
2282
(900.5–225145)
(627.3–77969)
581.5
244.5
(113–14700)
(65.0–3090)
1180
529.0
(230–14700)
(170–3090)
156.0
123.5
(113–5610)
(65.0–330)
2.58
2.05
(0.79–91.6)
(0.42–20.8)
p-value
0.008
0.773
<0.001
0.001
<0.001
0.006
0.232
The Mann–Whitney U test was used to compare the data between the groups, presented
as median (range).‡
WBC, white blood cell; CRP, C-reactive protein; IL, interleukin; NGAL, neutrophil
gelatinase-associated lipocalin; L-FABP, L-type fatty acid-binding protein; FIRS, fetal inflammatory
response syndrome; VD, vaginal delivery; CS, cesarean section.
24
Table 3. Maternal WBC level and amniotic fluid IL-6 and NGAL levels on multivariate
logistic regression analysis§
Data comparison
OR (95% CI)
p-value
WBC
4.02 (1.33–12.1)
0.013
IL-6
10.9 (3.41–35.0)
<0.001
NGAL
9.33 (2.86–30.4)
<0.001
§ WBC, white blood cell; IL, interleukin; NGAL, neutrophil gelatinase-associated lipocalin; OR, odds
ratio; CI, confidence interval.
25
Table 4. The relationship between amniotic fluid L-FABP levels and neonatal clinical
outcomes
Data comparison
L-FABP
p-value
control
CS (%)a
50.8
2.13
1.96
(61/120)
(0.42-24.7)
(0.57-17.3)
NICU admission
28.3
2.05
1.98
(%)a
(34/120)
(0.90-24.7)
(0.42-9.17)
Neonatal jaundice
10.8
2.69
1.97
(%)a
(13/120)
(1.06-17.3)
(0.42-24.7)
TTN (%)a
11.6
3.18
1.95
(14/120)
(1.06-24.7)
(0.42-13.9)
1.6
5.19
1.97
(2/120)
(4.07-6.31)
(0.42-24.7)
Respiratory support
14.1
4.57
1.94
(%)a
(17/120)
(0.90-24.7)
(0.42-9.17)
IVH (%)a
0.8
4.57
1.98
(1/120)
(4.57-4.57)
(0.42-24.7)
0.8
4.96
1.98
(1/120)
(4.96-4.96)
(0.42-24.7)
RDS (%)a
ROP (%)a
0.258
0.07
0.09
0.018
0.066
<0.001
0.237
0.194
26
The Mann–Whitney U-test was used for between-group comparisons, which are
presented as median (range).¶
L-FABP, L-type fatty acid-binding protein; CS, cesarean section; NICU, neonatal intensive care unit;
TTN, transient tachypnea of the newborn; RDS, respiratory distress syndrome; IVH, intraventricular
hemorrhage; ROP, retinopathy of prematurity.
27
Table 5. Maternal WBC and CRP levels and amniotic fluid IL-6, NGAL and L-FABP
levels in the spontaneous labor onset and control groups on univariate analysis
Data comparison
Spontaneous
Control
labor onset
(n=82)
p-value
(n=47)
WBC (/μL)a
CRP (mg/dL)a
IL-6 (pg/mL)a
NGAL
Total
(ng/mL)a
VD
CS
L-FABP (ng/ml)a
8700
7800
(5400-22900)
(4600-21700)
0.26
0.22
(0.05–3.21)
(0.04–7.27)
8738.4
2096.9
(737.4–225145)
(627.3–199347)
565
172.5
(142–14700)
(65.0–5610)
618
477
(170–14700)
(188–5610)
218
139
(142–3010)
(65.0–5610)
1.97
2.34
(0.79–17.3)
(0.42–91.6)
0.209
0.846
0.002
<0.001
0.411
0.013
0.512
The Mann–Whitney U-test was used for between-group comparisons, which are
presented as median (range).i
WBC, white blood cell; CRP, C-reactive protein; IL, interleukin; NGAL, neutrophil
gelatinase-associated lipocalin; L-FABP, L-type fatty acid-binding protein; FIRS, fetal inflammatory
response syndrome; VD, vaginal delivery; CS, cesarean section.
...
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