1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics, 2019. Cancer J. Clin. 2019, 69, 7–34. [CrossRef]
Rawla, P.; Sunkara, T.; Gaduputi, V. Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors. World J. Oncol.
2019, 10, 10–27. [CrossRef]
Center for Cancer Control and Information Services. Available online: https://ganjoho.jp/reg_stat/statistics/stat/summary
(accessed on 4 December 2020).
Egawa, S.; Toma, H.; Ohigashi, H.; Okusaka, T.; Nakao, A.; Hatori, T.; Maguchi, H.; Yanagisawa, A.; Tanaka, M. Japan pancreatic
cancer registry; 30th year anniversary: Japan Pancreas Society. Pancreas 2012, 41, 985–992. [CrossRef]
Hur, C.; Tramontano, A.C.; Dowling, E.C.; Brooks, G.A.; Jeon, A.; Brugge, W.R.; Gazelle, G.S.; Kong, C.Y.; Pandharipande, P.V. Early
pancreatic ductal adenocarcinoma survival is dependent on size: Positive implications for future targeted screening. Pancreas
2016, 45, 1062–1066. [CrossRef]
Tanaka, S.; Nakao, M.; Ioka, T.; Takakura, R.; Takano, Y.; Tsukuma, H.; Uehara, H.; Suzuki, R.; Fukuda, J. Slight dilatation of the
main pancreatic duct and presence of pancreatic cysts as predictive signs of pancreatic cancer: A prospective study. Radiology
2010, 254, 965–972. [CrossRef] [PubMed]
Yoon, S.H.; Lee, J.M.; Cho, J.Y.; Lee, K.B.; Kim, J.E.; Moon, S.K.; Kim, S.J.; Baek, J.H.; Kim, S.H.; Kim, S.H.; et al. Small (≤20 mm)
pancreatic adenocarcinomas: Analysis of enhancement patterns and secondary signs with multiphasic multidetector CT. Radiology
2011, 259, 442–452. [CrossRef] [PubMed]
Yamao, K.; Takenaka, M.; Ishikawa, R.; Okamoto, A.; Yamazaki, T.; Nakai, A.; Omoto, S.; Kamata, K.; Minaga, K.; Matsumoto, I.; et al.
Partial pancreatic parenchymal atrophy is a new specific finding to diagnose small pancreatic cancer (≤10 mm) including
carcinoma in situ: Comparison with localized benign main pancreatic duct stenosis patients. Diagnostics 2020, 10, 445. [CrossRef]
[PubMed]
Nakahodo, J.; Kikuyama, M.; Nojiri, S.; Chiba, K.; Yoshimoto, K.; Kamisawa, T.; Horiguchi, S.I.; Honda, G. Focal parenchymal
atrophy of pancreas: An important sign of underlying high-grade pancreatic intraepithelial neoplasia without invasive carcinoma,
i.e., carcinoma in situ. Pancreatology 2020, 20, 1689–1697. [CrossRef] [PubMed]
Japan Pancreas Society. General Rules for the Study of Pancreatic Cancer, 7th ed.; Kanehara & Co: Tokyo, Japan, 2016; pp. 12–57.
Satoh, T.; Kikuyama, M.; Kawaguchi, S.; Kanemoto, H.; Muro, H.; Hanada, K. Acute pancreatitis-onset carcinoma in situ
of the pancreas with focal fat replacement diagnosed using serial pancreatic-juice aspiration cytologic examination (SPACE).
Clin. J. Gastroenterol. 2017, 10, 541–545. [CrossRef]
Cotton, P.B.; Lehman, G.; Vennes, J.; Geenen, J.E.; Russell, R.C.; Meyers, W.C.; Liguory, C.; Nickl, N. Endoscopic sphincterotomy
complications and their management: An attempt at consensus. Gastrointest. Endosc. 1991, 37, 383–393. [CrossRef]
Okusaka, T.; Nakamura, M.; Yoshida, M.; Kitano, M.; Uesaka, K.; Ito, Y.; Furuse, J.; Hanada, K.; Okazaki, K. Clinical practice
guidelines for pancreatic cancer 2019 from the Japan Pancreas Society: A Synopsis. Pancreas 2020, 49, 326–335. [CrossRef]
Singhi, A.D.; Koay, E.J.; Chari, S.T.; Maitra, A. Early detection of pancreatic cancer: Opportunities and challenges. Gastroenterology
2019, 156, 2024–2040. [CrossRef]
Hanada, K.; Minami, T.; Shimizu, A.; Fukuhara, M.; Yano, S.; Sasaki, K.; Koda, M.; Sugiyama, K.; Yonehara, S.; Yanagisawa, A.
Roles of ERCP in the early diagnosis of pancreatic cancer. Diagnostics 2019, 9, 30. [CrossRef] [PubMed]
Hanada, K.; Okazaki, A.; Hirano, N.; Izumi, Y.; Minami, T.; Ikemoto, J.; Kanemitsu, K.; Hino, F. Effective screening for early
diagnosis of pancreatic cancer. Best Pract. Res. Clin. Gastroenterol. 2015, 29, 929–939. [CrossRef]
Sharma, C.; Eltawil, K.M.; Renfrew, P.D.; Walsh, M.J.; Molinari, M. Advances in diagnosis, treatment and palliation of pancreatic
carcinoma: 1990–2010. World J. Gastroenterol. 2011, 17, 867–897. [CrossRef] [PubMed]
Jung, K.W.; Kim, M.H.; Lee, T.Y.; Kwon, S.; Oh, H.C.; Lee, S.S.; Seo, D.W.; Lee, S.K. Clinicopathological aspects of 542 cases of
pancreatic cancer: A special emphasis on small pancreatic cancer. J. Korean Med. Sci. 2007, 22, S79–S85. [CrossRef]
Hanada, K.; Amano, H.; Abe, T. Early diagnosis of pancreatic cancer: Current trends and concerns. Ann. Gastroenterol. Surg. 2017,
1, 44–51. [CrossRef] [PubMed]
Kanno, A.; Masamune, A.; Hanada, K.; Kikuyama, M.; Kitano, M. Advances in early detection of pancreatic cancer. Diagnostics
2019, 9, 18. [CrossRef] [PubMed]
Kanno, A.; Masamune, A.; Hanada, K.; Maguchi, H.; Shimizu, Y.; Ueki, T.; Hasebe, O.; Ohtsuka, T.; Nakamura, M.; Takenaka, M.; et al.
Multicenter study of early pancreatic cancer in Japan. Pancreatology 2018, 18, 61–67. [CrossRef]
Diagnostics 2021, 11, 287
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
13 of 13
Kurihara, K.; Hanada, K.; Shimizu, A. Endoscopic ultrasonography diagnosis of early pancreatic cancer. Diagnostics 2020, 10, 1086.
[CrossRef]
Sakamoto, H.; Kitano, M.; Suetomi, Y.; Maekawa, K.; Takeyama, Y.; Kudo, M. Utility of contrast-enhanced endoscopic ultrasonography for diagnosis of small pancreatic carcinomas. Ultrasound Med. Biol. 2008, 34, 525–532. [CrossRef]
Yasuda, I.; Iwashita, T.; Doi, S.P.; Nakashima, M.; Moriwaki, H. Role of EUS in the early detection of small pancreatic cancer.
Dig. Endosc. 2011, 23, 22–25. [CrossRef]
Kumagi, T.; Terao, T.; Yokota, T.; Azemoto, N.; Kuroda, T.; Imamura, Y.; Uesugi, K.; Kisaka, Y.; Tanaka, Y.; Shibata, N.; et al. Early
detection of pancreatic cancer in patients with chronic liver disease under hepatocellular carcinoma surveillance. Mayo Clin. Proc.
2019, 94, 2004–2010. [CrossRef] [PubMed]
Kimura, H.; Ohtsuka, T.; Matsunaga, T.; Watanabe, Y.; Tamura, K.; Ideno, N.; Aso, T.; Miyazaki, T.; Osoegawa, T.; Aishima, S.; et al.
Predictors and diagnostic strategies for early-stage pancreatic ductal adenocarcinoma a retrospective study. Pancreas 2015, 44,
1148–1154. [CrossRef]
Iiboshi, T.; Hanada, K.; Fukuda, T.; Yonehara, S.; Sasaki, T.; Chayama, K. Value of cytodiagnosis using endoscopic nasopancreatic
drainage for early diagnosis of pancreatic cancer: Establishing a new method for the early detection of pancreatic carcinoma in
situ. Pancreas 2012, 41, 523–529. [CrossRef]
Cheng, C.L.; Sherman, S.; Watkins, J.L.; Barnett, J.; Freeman, M.; Geenen, J.; Ryan, M.; Parker, H.; Frakes, J.T.; Fogel, E.L.; et al.
Risk factors for post-ERCP pancreatitis: A prospective multicenter study. Am. J. Gastroenterol. 2006, 101, 139–147. [CrossRef]
[PubMed]
Freeman, M.L.; DiSario, J.A.; Nelson, D.B.; Fennerty, M.B.; Lee, J.G.; Bjorkman, D.J.; Overby, C.S.; Aas, J.; Ryan, M.E.; Bochna, G.S.; et al.
Risk factors for post-ERCP pancreatitis: A prospective, multicenter study. Gastrointest. Endosc. 2001, 54, 425–434. [CrossRef]
Testoni, P.A.; Mariani, A.; Giussani, A.; Vailati, C.; Masci, E.; Macarri, G.; Ghezzo, L.; Familiari, L.; Giardullo, N.; Mutignani, M.; et al.
Risk factors for post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators: A
prospective multicenter study. Am. J. Gastroenterol. 2010, 105, 1753–1761. [CrossRef] [PubMed]
Mouri, T.; Sasaki, T.; Serikawa, M.; Ishigaki, T.; Ishii, Y.; Shimizu, A.; Tsuboi, T.; Kurihara, K.; Tatsukawa, Y.; Miyaki, E.; et al.
A comparison of 4-Fr with 5-Fr endoscopic nasopancreatic drainage catheters: A randomized, controlled trial. J. Gastroenterol.
Hepatol. 2016, 31, 1783–1789. [CrossRef]
Chen, G.; Liu, S.L.; Zhao, Y.P.; Dai, M.H.; Zhang, T.P. Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration
for pancreatic cancer: A meta-analysis. Pancreatology 2013, 13, 298–304. [CrossRef] [PubMed]
Banafea, O.; Mghanga, F.P.; Zhao, J.F.; Zhao, R.F.; Zhu, L.R. Endoscopic ultrasonography with fine-needle aspiration for
histological diagnosis of solid pancreatic masses: A meta-analysis of diagnostic accuracy studies. BMC Gastroenterol. 2016, 16, 108.
[CrossRef]
Hanada, K.; Okazaki, A.; Hirano, N.; Izumi, Y.; Teraoka, Y.; Ikemoto, J.; Kanemitsu, K.; Hino, F.; Fukuda, T.; Yonehara, S.
Diagnostic strategies for early pancreatic cancer. J. Gastroenterol. 2015, 50, 147–154. [CrossRef]
Izumi, Y.; Hanada, K.; Okazaki, A.; Minami, T.; Hirano, N.; Ikemoto, J.; Kanemitsu, K.; Nakadoi, K.; Shishido, T.; Katamura, Y.; et al.
Endoscopic ultrasound findings and pathological features of pancreatic carcinoma in situ. Endosc. Int. Open 2019, 7, E585–E593.
[CrossRef]
Yane, K.; Kuwatani, M.; Yoshida, M.; Goto, T.; Matsumoto, R.; Ihara, H.; Okuda, T.; Taya, Y.; Ehira, N.; Kudo, T.; et al. Nonnegligible rate of needle tract seeding after endoscopic ultrasound-guided fine-needle aspiration for patients undergoing distal
pancreatectomy for pancreatic cancer. Dig. Endosc. 2020, 32, 801–811. [CrossRef] [PubMed]
Minaga, K.; Takenaka, M.; Katanuma, A.; Kitano, M.; Yamashita, Y.; Kamata, K.; Yamao, K.; Watanabe, T.; Maguchi, H.; Kudo, M.
Needle tract seeding: An overlooked rare complication of endoscopic ultrasound-guided fine-needle aspiration. Oncology 2017,
93, 107–112. [CrossRef]
Japan Pancreas Society. Available online: http://suizou.org/pdf/guide2019_P176-179.pdf (accessed on 29 October 2019).
Yu, J.; Li, A.; Hong, S.M.; Hruban, R.H.; Goggins, M. MicroRNA alterations of pancreatic intraepithelial neoplasias. Clin. Cancer Res.
2012, 18, 981–992. [CrossRef] [PubMed]
Mori, Y.; Ohtsuka, T.; Kono, H.; Nagayoshi, Y.; Ideno, N.; Aso, T.; Kozono, S.; Ohuchida, K.; Takahata, S.; Nakamura, M.; et al. A
Minimally invasive and simple Screening test for detection of pancreatic ductal adenocarcinoma using biomarkers in duodenal
juice. Pancreas 2013, 42, 187–192. [CrossRef] [PubMed]
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