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Predictors of lower limb fractures in general Japanese: NIPPON DATA90.

SAITO Yoshino 80553784 MIURA Katsuyuki 90257452 0000-0002-2646-9582 ARIMA Hisatomi 20437784 0000-0002-2064-2014 HAYAKAWA Takehito TAKASHIMA Naoyuki 80435883 0000-0002-9593-6797 KITA Yoshikuni OKUDA Nagako 80452233 0000-0002-6893-0509 FUJIYOSHI Akira 10567077 0000-0002-5790-7119 IWAHORI Toshiyuki MIYAGAWA Naoko 20388169 0000-0002-9148-1078 KONDO Keiko 20566567 TORII Sayuki 30773973 KADOTA Aya 60546068 0000-0001-7378-0544 OHKUBO Takayoshi 60344652 0000-0002-3283-8196 OKAYAMA Akira 60169159 OKAMURA Tomonori 00324567 UESHIMA Hirotsugu 70144483 0000-0002-7742-4253 NIPPON DATA90 Research Group 滋賀医科大学

2022.02.02

概要

Objective:
This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population.
Methods:
NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures).
Results:
The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow-up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age.
Conclusions:
Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women.

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