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Malignant Progression of Diffuse Low-grade Gliomas : A Systematic Review and Meta-analysis on Incidence and Related Factors.

NAKASU Satoshi 00135477 0000-0001-8719-9806 NAKASU Yoko 10135478 滋賀医科大学

2022.04.15

概要

Malignant progression of diffuse low-grade glioma (LGG) is a critical event affecting patient survival; however, the incidence and related factors have been inconsistent in literature. According to the PRISMA guidelines, we systematically reviewed articles from 2009, meta-analyzed the incidence of malignant progression, and clarified factors related to the transformation. Forty-one articles were included in this study (n = 7,122; n, number of patients). We identified two definitions of malignant progression: histologically proven (Htrans) and clinically defined (Ctrans). The malignant progression rate curves of Htrans and Ctrans were almost in parallel when constructed from the results of meta-regression by the mean follow-up time. The true transformation rate was supposed to lie between the two curves, approximately 40% at the 10-year mean follow-up. Risk of malignant progression was evaluated using hazard ratio (HR). Pooled HRs were significantly higher in tumors with a larger pre- and postoperative tumor volume, lower degree of resection, and notable preoperative contrast enhancement on magnetic resonance imaging than in others. Oligodendroglial histology and IDH mutation (IDHm) with 1p/19q codeletion (Codel) also significantly reduced the HRs. Using Kaplan-Meier curves from eight studies with molecular data, we extracted data and calculated the 10-year malignant progression-free survival (10yMPFS). The 10yMPFS in patients with IDHm without Codel was 30.4% (95% confidence interval [95% CI]: 22.2-39.0) in Htrans and 38.3% (95% CI: 32.3-44.3) in Ctrans, and that with IDHm with Codel was 71.7% (95% CI: 61.7-79.5) in Htrans and 62.5% (95% CI: 55.9-68.5) in Ctrans. The effect of adjuvant radiotherapy or chemotherapy could not be determined.

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参考文献

Several limitations associated with the present study

warrant mention. First, the accumulated data were obtained from retrospective studies with a moderate quality,

which might have caused some bias. Second, we attempted

to establish two definitions of malignant transformation.

This might have been inappropriate in some cases, as the

histological diagnosis rate for recurrences might differ

among institutes, and some institutes employed various

MRI sequences or positron emission tomography for the

Neurol Med Chir (Tokyo) 62, April, 2022

1) Louis DN, Ohagaki H, Wiestler OD, et al.: WHO classification of

tumours of the central nervous system, International Agency for

Research on Cancer, Lyon, 2016

2) Louis DN, Perry A, Wesseling P, et al.: The 2021 WHO Classification of Tumors of the Central Nervous System: A summary.

Neuro Oncol 23: 1231-1251, 2021

3) Nakasu S, Notsu A, Nakasu Y: Prevalence of incidental meningiomas and gliomas on MRI: A meta-analysis and metaregression analysis. Acta Neurochir (Wien) 163: 3401-3415, 2021

184

S. Nakasu et al.

4) Jansen E, Hamisch C, Ruess D, et al.: Observation after surgery

for low grade glioma: Long-term outcome in the light of the

2016 WHO classification. J Neurooncol 145: 501-507, 2019

5) Thon N, Eigenbrod S, Kreth S, et al.: IDH1 mutations in grade II

astrocytomas are associated with unfavorable progression-free

survival and prolonged postrecurrence survival. Cancer 118: 452460, 2012

6) Lima GL, Zanello M, Mandonnet E, Taillandier L, Pallud J,

Duffau H: Incidental diffuse low-grade gliomas: From early detection to preventive neuro-oncological surgery. Neurosurg Rev 39:

377-384, 2016

7) Duffau H: Long-term outcomes after supratotal resection of diffuse low-grade gliomas: A consecutive series with 11-year followup. Acta Neurochir (Wien) 158: 51-58, 2016

8) Narang AK, Chaichana KL, Weingart JD, et al.: Progressive lowgrade glioma: Assessment of prognostic importance of histologic

reassessment and MRI findings. World Neurosurg 99: 751-757,

2017

9) Capelle L, Fontaine D, Mandonnet E, et al.: Spontaneous and

therapeutic prognostic factors in adult hemispheric World

Health Organization Grade II gliomas: A series of 1097 cases:

Clinical article. J Neurosurg 118: 1157-1168, 2013

10) Obara T, Blonski M, Brzenczek C, et al.: Adult diffuse low-grade

gliomas: 35-year experience at the nancy france neurooncology

unit. Front Oncol 10: 2020

11) Tom M, Park D, Wei W, et al.: Malignant transformation of adult

low grade glioma: Risk factors and outcomes in the molecular

era. Int J Radiat Oncol Biol Phys 105: S143, 2019

12) Cesselli D, Ius T, Isola M, et al.: Application of an artificial intelligence algorithm to prognostically stratify grade II gliomas. Cancers 12: 50, 2021

13) Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR: Practical

methods for incorporating summary time-to-event data into

meta-analysis. Trials 8: 16, 2007

14) Aoki K, Suzuki H, Yamamoto T, et al.: Mathematical modeling

and mutational analysis reveal optimal therapy to prevent malignant transformation in grade II IDH-mutant gliomas. Cancer Res

81: 4861-4873, 2021

15) Ahmadi R, Dictus C, Hartmann C, et al.: Long-term outcome and

survival of surgically treated supratentorial low-grade glioma in

adult patients. Acta Neurochir (Wien) 151: 1359-1365, 2009

16) Bauman G, Fisher B, Watling C, Cairncross JG, Macdonald D:

Adult supratentorial low-grade glioma: Long-term experience at

a single institution. Int J Radiat Oncol Biol Phys 75: 1401-1407,

2009

17) Dahlrot RH, Kristensen BW, Hjelmborg J, Herrstedt J, Hansen S:

A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1). J Neurooncol 114: 309-317, 2013

18) El-Hateer H, Souhami L, Roberge D, et al.: Low-grade oligodendroglioma: an indolent but incurable disease? Clinical article. J

Neurosurg 111: 265-271, 2009

19) Etxaniz O, Carrato C, de Aguirre I, et al.: IDH mutation status

trumps the Pignatti risk score as a prognostic marker in lowgrade gliomas. J Neurooncol 135: 273-284, 2017

20) Gousias K, Schramm J, Simon M: Extent of resection and survival in supratentorial infiltrative low-grade gliomas: Analysis of

and adjustment for treatment bias. Acta Neurochir (Wien) 156:

327-337, 2014

21) Heo YJ, Park JE, Kim HS, et al.: Prognostic relevance of gemistocytic grade II astrocytoma: Gemistocytic component and MR imaging features compared to non-gemistocytic grade II astrocytoma. Eur Radiol 27: 3022-3032, 2017

22) Iwadate Y, Matsutani T, Hirono S, Ikegami S, Shinozaki N, Saeki

N: IDH1 mutation is prognostic for diffuse astrocytoma but not

low-grade oligodendrogliomas in patients not treated with early

radiotherapy. J Neurooncol 124: 493-500, 2015

23) Jaber M, Ewelt C, Wölfer J, et al.: Is visible aminolevulinic acidinduced fluorescence an independent biomarker for prognosis in

histologically confirmed (World Health Organization 2016) lowgrade gliomas? Neurosurgery 84: 1214-1224, 2019

24) Jung TY, Jung S, Moon JH, et al.: Early prognostic factors related

to progression and malignant transformation of low-grade

gliomas. Clin Neurol Neurosurg 113: 752-757, 2011

25) Juratli TA, Kirsch M, Robel K, et al.: IDH mutations as an early

and consistent marker in low-grade astrocytomas WHO grade II

and their consecutive secondary high-grade gliomas. J Neurooncol

108: 403-410, 2012

26) Karschnia P, Teske N, Dorostkar MM, et al.: Extent and prognostic value of MGMT promotor methylation in glioma WHO grade

II. Sci Rep 10: 19758, 2020

27) Kavouridis VK, Boaro A, Dorr J, et al.: Contemporary assessment

of extent of resection in molecularly defined categories of diffuse

low-grade glioma: A volumetric analysis. J Neurosurg 133: 12911301, 2019

28) Koo T, Lim DH, Seol HJ, et al.: Impact of adjuvant treatments on

survival in Korean patients with WHO grade II gliomas: KNOG

15-02 and KROG 16-04 intergroup study. J Neurooncol 140: 445455, 2018

29) Leu S, von Felten S, Frank S, Boulay JL, Mariani L: IDH mutation

is associated with higher risk of malignant transformation in

low-grade glioma. J Neurooncol 127: 363-372, 2016

30) Majchrzak K, Kaspera W, Bobek-Billewicz B, et al.: The assessment of prognostic factors in surgical treatment of low-grade

gliomas: A prospective study. Clin Neurol Neurosurg 114: 11351144, 2012

31) Snyder LA, Wolf AB, Oppenlander ME, et al.: The impact of extent of resection on malignant transformation of pure oligodendrogliomas. J Neurosurg 120: 309-314, 2014

32) Suzuki A, Maruyama T, Nitta M, et al.: Evaluation of DNA ploidy

with intraoperative flow cytometry may predict long-term survival of patients with supratentorial low-grade gliomas: Analysis

of 102 cases. Clin Neurol Neurosurg 168: 46-53, 2018

33) Tanaka K, Sasayama T, Mizukawa K, et al.: Combined IDH1 mutation and MGMT methylation status on long-term survival of

patients with cerebral low-grade glioma. Clin Neurol Neurosurg

138: 37-44, 2015

34) Turkoglu E, Gurer B, Sanli AM, et al.: Clinical outcome of surgically treated low-grade gliomas: A retrospective analysis of a single institute. Clin Neurol Neurosurg 115: 2508-2513, 2013

35) Youland RS, Brown PD, Giannini C, Parney IF, Uhm JH, Laack

NN: Adult low-grade glioma: 19-year experience at a single institution. Am J Clin Oncol 36: 612-619, 2013

36) Zhang S, Chiang GC, Magge RS, et al.: Texture analysis on conventional MRI images accurately predicts early malignant transformation of low-grade gliomas. Eur Radiol 29: 2751-2759, 2019

37) Chaichana KL, McGirt MJ, Laterra J, Olivi A, Quiñones-Hinojosa

A: Recurrence and malignant degeneration after resection of

adult hemispheric low-grade gliomas. J Neurosurg 112: 10-17,

2010

38) Eseonu CI, Eguia F, ReFaey K, et al.: Comparative volumetric

analysis of the extent of resection of molecularly and histologically distinct low grade gliomas and its role on survival. J

Neurooncol 134: 65-74, 2017

39) Fukuya Y, Ikuta S, Maruyama T, et al.: Tumor recurrence pat-

Neurol Med Chir (Tokyo) 62, April, 2022

Malignant Progression of Low-grade Gliomas

40)

41)

42)

43)

44)

45)

46)

47)

48)

terns after surgical resection of intracranial low-grade gliomas. J

Neurooncol 144: 519-528, 2019

Jakola AS, Myrmel KS, Kloster R, et al.: Comparison of a strategy

favoring early surgical resection vs a strategy favoring watchful

waiting in low-grade gliomas. JAMA 308: 1881-1888, 2012

Jungk C, Scherer M, Mock A, et al.: Prognostic value of the extent of resection in supratentorial WHO grade II astrocytomas

stratified for IDH1 mutation status: A single-center volumetric

analysis. J Neurooncol 129: 319-328, 2016

Ross DA, Tao S, Gultekin S, Ross AM: Lobar distribution of low

grade oligodendroglioma: Distribution, molecular characteristics,

and survival based upon location. J Cancer Ther 5: 1249, 2014

Jansen NL, Suchorska B, Wenter V, et al.: Dynamic 18F-FET PET

in newly diagnosed astrocytic low-grade glioma identifies highrisk patients. J Nucl Med 55: 198-203, 2014

Patel T, Bander ED, Venn RA, et al.: The role of extent of resection in IDH1 wild-type or mutant low-grade gliomas. Neurosurgery 82: 808-814, 2018

Sakarunchai I, Sangthong R, Phuenpathom N, Phukaoloun M:

Free survival time of recurrence and malignant transformation

and associated factors in patients with supratentorial low-grade

gliomas. J Med Assoc Thai 96: 1542-1549, 2013

Smith JS, Chang EF, Lamborn KR, et al.: Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas.

J Clin Oncol 26: 1338-1345, 2008

Gozé C, Blonski M, Le Maistre G, et al.: Imaging growth and isocitrate dehydrogenase 1 mutation are independent predictors for

diffuse low-grade gliomas. Neuro Oncol 16: 1100-1109, 2014

Murphy ES, Leyrer CM, Parsons M, et al.: Risk factors for malignant transformation of low-grade glioma. Int J Radiat Oncol Biol

Neurol Med Chir (Tokyo) 62, April, 2022

185

Phys 100: 965-971, 2018

49) Pallud J, Blonski M, Mandonnet E, et al.: Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse lowgrade gliomas. Neuro Oncol 15: 595-606, 2013

50) Weller J, Katzendobler S, Karschnia P, et al.: PCV chemotherapy

alone for WHO grade 2 oligodendroglioma: Prolonged disease

control with low risk of malignant progression. J Neurooncol 2021

51) Wen B, Fu F, Hu L, et al.: Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients

with low grade astrocytoma. Clin Neurol Neurosurg 168: 12-17,

2018

52) Zeng L, Mei Q, Li H, Ke C, Yu J, Chen J: A survival analysis of

surgically treated incidental low-grade glioma patients. Sci Rep

11: 8522, 2021

53) Johnson BE, Mazor T, Hong C, et al.: Mutational analysis reveals

the origin and therapy-driven evolution of recurrent glioma. Science 343: 189-193, 2014

54) Yu Y, Villanueva-Meyer J, Grimmer MR, et al.: Temozolomideinduced hypermutation is associated with distant recurrence and

reduced survival after high-grade transformation of low-grade

IDH-mutant gliomas. Neuro Oncol 23: 1872-1884, 2021

55) Aihara K, Mukasa A, Nagae G, et al.: Genetic and epigenetic stability of oligodendrogliomas at recurrence. Acta Neuropathol

Commun 5: 18, 2017

Corresponding author: Satoshi Nakasu, M.D.

Division of Neurosurgery, Omi Medical Center, 1660 Yabase-cho,

Kusatsu, Shiga 525-8585, Japan.

e-mail: neuro-nakasu@kfx.biglobe.ne.jp

...

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