Several limitations associated with the present study
warrant mention. First, the accumulated data were obtained from retrospective studies with a moderate quality,
which might have caused some bias. Second, we attempted
to establish two definitions of malignant transformation.
This might have been inappropriate in some cases, as the
histological diagnosis rate for recurrences might differ
among institutes, and some institutes employed various
MRI sequences or positron emission tomography for the
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Corresponding author: Satoshi Nakasu, M.D.
Division of Neurosurgery, Omi Medical Center, 1660 Yabase-cho,
Kusatsu, Shiga 525-8585, Japan.
e-mail: neuro-nakasu@kfx.biglobe.ne.jp
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