リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas.」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
リケラボ

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas.

堀田 尚誠 津端 由佳里 谷野 明里 中尾 美香 天野 芳宏 濱口 愛 濱口 俊一 岸本 晃司 礒部 威 島根大学 DOI:10.21203/rs.3.rs-27772/v2

2020.06.22

概要

Background
Multiple synchronous ground glass nodules (GGNs) are known to be malignant, however, they tend to progress slowly. Multiple synchronous lesions in the same patient which show different characteristics must be treated individually.
Methods
This was a retrospective review of 34 lung adenocarcinoma patients with multiple synchronous GGNs in an Asian population. One hundred twenty-seven single lung adenocarcinoma patients were included for comparison purposes. The follow-up period was 5 years for all patients.
Results
The 5-year overall survival (OS) patients with multiple lesions did not differ from that of the patients with single lesions to a statistically significant extent (Single: 81.8% vs. Multiple: 88.2%, P = 0.3602). Dominant tumors (DTs) with a ground glass component and consolidation were divided into three categories based on the consolidation-to-tumor ratio on radiological imaging. No significant differences were observed among the three DT categories. Twenty-four patients had unresected GGNs, while a progression of the unresected GGN occurred in 10 of these cases. The OS and disease-free survival (DFS) curves of patients with and without GGN progression did not differ to a statistically significant extent (OS: 80% vs. 92.9%, P = 0.3870; DFS: 80% vs. 100%, P = 0.0977).
Conclusions
The outcomes were best predicted by the stage of the DT. After surgery patients require a careful follow-up because unresected GGNs may show progression. At the same time, the increase in residual lesions and the appearance of new GGNs were not related to OS. The management of such patients should be determined according to the DT with the worst prognosis.

論文の公開元へ

この論文で使われている画像

関連論文

関連論文をもっと見る

参考文献

1. Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality

with low-dose computed tomographic screening. N Engl J Med. 2011;

365:395–409.

2. Church TR, Black WC, Aberle DR, et al. Results of initial low-dose computed

tomographic screening for lung cancer. N Engl J Med. 2013;368:1980–91.

3. Zhao SJ, Wu N. Early detection of lung cancer: low-dose computed

tomography screening in China. Thoracic Cancer. 2015;6:385–9.

4. Nawa T, Nakagawa T, Mizoue T, et al. Low-dose computed tomography

screening in Japan. J Thorac Imaging. 2015;30:108–14.

5. Yousaf-Khan U, van der Aalst C, de Jong PA, et al. Final screening round of

the NELSON lung cancer screening trial: the effect of a 2.5-year screening

interval. Thorax. 2017;72:48–56.

6. Sihoe AD, Cardillo G. Solitary pulmonary ground-glass opacity: is it time for

new surgical guidelines? Eur J Cardiothorac Surg. 2017;52:848–51.

Lococo F, Cusumano G, De Filippis AF, et al. Current practices in the

Management of Pulmonary Ground-Glass Opacities: a survey of SICT

members. Ann Thorac Surg. 2018;106:1504–11.

Wu C, Zhao C, Yang Y, et al. High discrepancy of driver mutations in

patients with NSCLC and synchronous multiple lung ground-glass nodules.

J Thorac Oncol. 2015;10:778–83.

Liu M, He WX, Song N, et al. Discrepancy of epidermal growth factor

receptor mutation in lung adenocarcinoma presenting as multiple groundglass opacities. Eur J Cardiothorac Surg. 2016;50:909–13.

Park E, Ahn S, Kim H, et al. Targeted sequencing analysis of pulmonary

adenocarcinoma with multiple synchronous ground-glass/Lepidic nodules. J

Thorac Oncol. 2018;13:778–83.

Shimada Y, Saji H, Otani K, et al. Survival of a surgical series of lung cancer

patients with synchronous multiple ground-glass opacities, and the

management of their residual lesions. Lung Cancer. 2015;88:174–80.

Hattori A, Matsunaga T, Takamochi K, et al. Radiological classification of

multiple lung cancers and the prognostic impact based on the presence of

a ground glass opacity component on thin section computed tomography.

Lung Cancer. 2017;113:7–13.

Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant

tumours. 7th ed: Wiley-Blackwell; 2009.

Gu B, Burt BM, Merritt RE, et al. A dominant adenocarcinoma with multifocal

ground glass lesions does not behave as advanced disease. Ann Thorac

Surg. 2013;96:411–8.

Gao RW, Berry MF, Kunder CA, et al. Survival and risk factors for progression

after resection of the dominant tumor in multifocal, lepidic-type pulmonary

adenocarcinoma. J Thorac Cardiovasc Surg. 2017;154:2092–9.

Bongiolatti S, Corzani R, Borgianni S, et al. Long-term results after surgical

treatment of the dominant lung adenocarcinoma associated with groundglass opacities. J Thorac Dis. 2018;10:4838–48.

Hasegawa M, Sone S, Takashima S, et al. Growth rate of small lung cancers

detected on mass CT screening. Br J Radiol. 2000;73:1252–9.

Aoki T, Nakata H, Watanabe H, et al. Evolution of peripheral lung

adenocarcinomas: CT findings correlated with histology and tumor

doubling time. AJR Am J Roentgenol. 2000;174:763–8.

Kobayashi Y, Fukui T, Ito S, et al. How long should small lung lesions of

ground-glass opacity be followed? J Thorac Oncol. 2013;8:309–14.

Suh YJ, Lee HJ, Kim YJ, et al. Computed tomography characteristics of lung

adenocarcinomas with epidermal growth factor receptor mutation: a

propensity score matching study. Lung Cancer. 2018;123:52–9.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in

published maps and institutional affiliations.

...

参考文献をもっと見る