荷電粒子入射反応における医療用放射性核種169Ybの生成断面積測定

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荷電粒子入射反応における医療用放射性核種169Ybの生成断面積測定

花田, 萌美

北海道大学. 博士(医理工学) 甲第14118号

2020-03-25

10.14943/doctoral.k14118

http://hdl.handle.net/2115/78121

theses (doctoral)

Moemi_Hanada.pdf

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Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP

、

Yb

169

(Cross section measurements of charged-particle induced reactions
to produce medical radionuclide 169Yb)

2020

3

(Moemi HANADA)
1

、

Yb

169

(Cross section measurements of charged-particle induced reactions
to produce medical radionuclide 169Yb)

2020

3

(Moemi HANADA)

...................................................................................................................1

、
1.

............................................................................................................................................................................2
1.1

n

1.2

..................................................................................................................................................2
n

..........................................................................................................................3

1.3

-169L169YbM ......................................................................................................................................4

1.4 169Yb

................................................................................................................................................................5

1.4.1 169Tm

................................................................................................................................................................ 6

1.4.2 169Tm

........................................................................................................................................................... 7

169

1.4.3 Tm

............................................................................................................................................. 8

1.4.4 natEr

.............................................................................................................................................10

1.5

...................................................................................................................................................................11

........................................................................................................................................................................ 12
2.

............................................................................................................................................................... 13
2.1

Lactivation methodM..................................................................................................................................13

2.2

Lstacked foil methodM ...............................................................................................................................13

2.3

Lgamma-ray spectrometryM.......................................................................................................14

2.4

.................................................................................................................................................................................15

2.5

...................................................................................................................................................................16

3.

............................................................................................................................................................... 17
3.1 169Tm

..................................................................................................................18

3.1.1

......................................................................................................................................................................................................18

3.1.2

..................................................................................................................................................................................19

3.1.3

............................................................................................................................................................................................20

3.1.4

............................................................................................................................................................................................21

3.2 natEr

.....................................................................................................................22

3.2.1

......................................................................................................................................................................................................22

3.2.2

..................................................................................................................................................................................24

3.2.3

............................................................................................................................................................................................24

3.2.4

............................................................................................................................................................................................25

4.

............................................................................................................................................................... 26
4.1 169Tm

..................................................................................................................26

4.1.1 169Yb
169

4.1.2 Yb

............................................................................................................................................................................................28
.......................................................................................................................................................................................29

4.1.3

..............................................................................................................................................................................30

4.2 natEr

.....................................................................................................................37

4.2.1 169Yb
169

4.2.2 Yb
4.2.3

............................................................................................................................................................................................39
...................................................................................................................................................................................40
..............................................................................................................................................................................41

5.

......................................................................................................................................................................... 48

6.

、 ................................................................................................................................................. 49
............................................................................................................................................................................. 50
................................................................................................................................................................... 51

、
t
、
H
1. M. Saito, M. Aikawa, H. Haba, Y. Komori, S. Takács
Production cross sections of 169Yb and Tm isotopes in deuteron-induced reactions on 169Tm
Applied Radiation and Isotopes 125, 23-26, 2017
2. M. Saito, M. Aikawa, M. Sakaguchi, N. Ukon, H. Haba, Y. Komori, S. Takács
Production cross sections of ytterbium and thulium radioisotopes in alpha-induced nuclear
reactions on natural erbium
Applied Radiation and Isotopes 154, 108874, 2019
t
a.

H
Sandor Takacs

・
169
Tm

169

Yb

2016
b.

9

7

~9

I

・
169

Yb

2019
c.

, 2016
nat

Er

, 2019

50 MeV
3

20

~22

I
Sandor Takacs

・
169

2019

1

, 2019

Yb
9 11

~13

I

I

1.
1.1

n
t
H

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t

mt

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8.02

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H

m
H

a

V
nV

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59.4

I

mQ H

V

H
n

H
-192L192IrM

73.8
V

I

mQ H
H

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6

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n
tomography, SPECTM
M
8
T

H
n

a
t
99m
m Tc
H

L

mt 140 keVM
a
LSingle photon emission computed
mQ 99MoLT1/2 = 66
H
m

-18L18FM
keV
PETM

110
a

n
511
LPositron emission tomography,
b

mQ H

n

n
H
n

H
t am

H
V
H

2

n

m
H

t 100

(U.S. Department of Energy)

T n
H

1.2

n
t

a

Q H
mQ
t
mQ

a
n
Lcross sectionM Q H V
H
a
m
Q
Q

g

a
t
n

H
a
a
n
t
m
Lthick target yield, TTYM
H V
m
Q
t
(Otuka and Sándor Takács, 2015)
a H
m
a
t
a
Q H
Q H
mt
99m
a
n m
Tc
mQ 99Mo
H V
m
H
n
[
(Van
Noorden, 2013)
Y
Y
Yt
H
V
H
T n
99
Mo/99mTc
t
15
n
(Van
Noorden, 2013)H
t
T
H
V
H
m
t
n
H
nt
a
nmQ H
mt
nt
n
mQ H
n m
H
t
t
n
-169L169YbM
a
H

3

1.3

-169L169YbM

169

Yb t
mQ H
nV
al., 2006)H

32.02
125

I
e
n

m 49.8 keV V
192

Ir

a

307.7 keV
n

1
a
m
1 169Yb n

L

93 keVM

mQ n T
aH
n
e

]n

a
mQ
(Lymperopoulou et

H
125

I

192

Ir

169

32.0

g

49.8 - 308.7 keV

93 keV

168

125

I

59.4

g

35.5 keV (g), 27.5 keV
31.0 keV (
X )

28.5 keV

124

192

73.8

Yb

Ir

nV

4

b g

130 - 1060 keV (b), 256 - 350 keV
672 keV (g)

177.21 keVLIg = 22.16%Mn 197.96 keVLIg = 35.8%M
169
Yb
L169Yb-DTPAM
(DeLand et al., 1971)H

Yb(n,g)169Yb
Xe(n,g)125Xe
125
I

191

Ir(n,g)192Ir

m

1.4 169Yb
1-1

169

Yb

aH

(-,

(--

(-.

(-

(-+

(-,

(--

(-

(-+

(-,

5

.(

5

5

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(-.

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5

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. ...

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