Albarado D.C., McClaine J., Stephens J.M., et al. (2004) Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endcrinology 145, 243-252.
Auerbach A.B. (2004) Production of functional trangenic mice by DNA pronuclear microinjection. Acta Biochim. Pol. 51, 9031
Auerbach A.B., Norinsky R., Ho W., Losos K., Guo Q., Chatterjee S. and Joyner A.L. (2003) Strain-dependent differences in the efficiency of transgenic mouse production. Transgenic Res.12, 59-69
Balthasar N., Dalgaard L.T., Lee C.E., et al. (2005) Divergence of melanocotin pathways in the control of food intake and energy expenditure. Cell 123, 493-505.
Baron J., Tarnow C., Mayoli-Nussle D., Schilling E., Meyer D., Hammami M., Schwalm F., Sterinmetzer T., Guan Y., Garten W., Klenk H.D. and Bottcher-Friebertshauser E. (2013) Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses. J. Virol. 87, 1811-1820.
Beaufort N., Leduc D., Eguchi H., Mengele K., Hellmann D., Masegi T., Kamimura T., Yasuoka S., Fend F., Chignard M. and Pidard D. (2007) The human airway trypsin-like protease modulates the urokinase receptor (uPAR, CD87) structure and functions. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L1263-L1272
Bertram S., Clowacka I., Muller M.A., Lavender H., Gnirss K., Nehlmeier I., Niemeyer D., He Y., Simmons G., Drosten C., Soilleux E.J., Jahn O., Steffen I., and Pohlmann S. (2011) Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease. J. Virol. 85, 13363-13372.
Bonnerot C., Vernet M., Grimber G., Briand P. and Nicolas J.F. (1991) Transcriptional selectivity in early mouse embryos: a qualitative study. Nucleic Acids Res. 19, 7251-7257
Bottcher E., Matrosovich T., Beyerle M., Klenk H.-D., Garten W. and Matrosovich M. (2006) Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. J. Virol. 80, 9896-9898
Burdon T.G. and Wall R.J. (1992) Fate of microginjected genes in preimplantation mouse embryos. Mol. Reprod. Dev. 33, 436-442
Cai X., Hagedorn C.H. and Cullen B.R. 2004. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10, 1957-1966.
Capecchi M.R. (1989) Altering the genome by homologous recombination. Science 244, 1288-1292.
Chaipan C., Kobasa D., Bertram S., Glowacka I., Steffen I., Tsegaye T.S., Takeda M., Bugge T.H., Kim S., Park Y., Marzi A., and Pohlmann S. (2009) Proteolytic activation of the 1918 influenza virus hemagglutinin. J. Virol. 83, 3200-3211.
Cheng H., Fukushima T., Takahashi N., Tanaka H., and Kataoka H. (2009) Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membranebound serine proteinases. Cancer Res. 69, 1828-1835.
Chokki M., Eguchi H., Hamamura I., Mitsuhashi H. and Kamimura T. (2005) Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF -converting enzyme activity in airway epithelial cells. FEBS J. 272, 6387-6399
Chokki M., Yamamura S., Eguchi H., Masegi T., Horiuchi H., Tanabe H., Kamimura T. and Yasuoka S. (2003) Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 30, 470-478
Chung K.H., Hart C.C., Al-Bassam S., Avery A., Taylor J., Patel P.D., Vojtek A.B. and Turner D.L. (2006) Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155. Nucleic Acids Res. 34, e53
Claas E.C.J., Osterhaus A.D.M.E., Van Beek R., De Jong J.C., Rimmelzwaan G.F., Senne D.A., Krauss S., Shortridge K.F., and Webster R.G. (1998) Human influenza A H5N1 virus related to a highly pathogenic human influenza virus. Lancet, 351, 472-477.
Clark A.J., Cowper A., Wallace R., Wright G. and Simons J.P. 1992. Rescuing transgene expression by co-integration. Nat. Biotech. 10, 1450-1454.
Corish P. and Tyler-Smith C. (1999) Attenuation of green fluorescent protein half-life in mammalian cells. Protein Eng. 12, 1035-1040
Cormack B.P., Valdivia R.H. and Falkow S. (1996) FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173, 33-38.
Coumoul X., Shukla V., Li C., Wang R.-H. and Deng C.-X. (2005) Conditional knockdown of Fgfr2 in mice using Cre-loxP induced RNA interference. Nucl. Acids Res. 33, e102.
Denda K., Shimomura T., Kawaguchi T., Miyazawa K. and Kitamura N. (2002) Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. J. Biol. Chem. 277, 14053-14059
Deyde V.M., Xu X.Y., Bright R.A., Shaw M., Smith C.B., Zhang A., et al. (2007) Surveillance of resistance to adamantanes among influenza A (H3N2) and A (H1N1) viruses isolated worldwide. J. Infect. Dis. 196, 249–257.
Fan B., Brennan J., Grant D., Peale F., Rangell L. and Kirchhofer D. (2007) Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth. Dev. Biol. 303, 222-230
Fan B., Wu T.D., Li W. and Kirchhofer D. (2005) Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. J. Biol. Chem. 280, 34513-34520
Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E. and Mello C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 392, 806-811.
Godiksen S., Selzer-Plon J., Pedersen E.D.K., Abell K., Rasmussen H.B., Szabo R., Bugge T.H. and Vogel L.K. (2008) Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary. Biochem. J. 413, 251-259
Grimm D., Streetz K.L., Jopling C.L., et al. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 44, 537-541.
Hamilton B.S., and Whittaker G.R. (2013) Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12. J. Biol. Chem. 288, 17399-17407.
Han J., Lee Y., Yeom K.H., Nam J.W., Heo I., Rhee J.K., Sohn S.Y., Cho Y., Zhang B.T. and Kim V.N. (2006) Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125, 887-901.
Harborth J., Elbashir S.M., Bechert K., et al. (2001) Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci. 114, 4557-4565.
Hashimoto T., Kato M., Shimomura T. and Kitamura N. (2010) TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activatoro inhibitor type 1 and activates pro-hepatocyte growth factor. FEBS J. 277, 4888-4900.
He M., Liu Y., Wang X., et al. (2012) Cell-type based analysis of microRNA profiles in the mouse brain. Neuron 73, 35-48.
Hemann M.T., Fridman J.S., Zilfou J.T., et al. (2003) An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat. Genet. 33, 396-400.
Herter S., Piper D.E., Aaron W., Gabriele T., Cuter G., Cao P., Bhatt A.S., Choe Y., Craik C.S., Walker N., Meininger D., Hoey T. and Austin R.J. (2005) Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem. J. 390, 125-136
Hofmann A., Kessler B., Ewerling S., Weppert M., Vogg B., Ludwig H., Stojkovic M., Boelhauve M., Brem G., Wolf E. and Pfeifer A. (2003) Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep. 4, 1054-1060.
Hofmann A., Zakhartchenko V., Weppert M., Sebald H., Wenigerkind H., Brem G., Wolf E. and Pfeifer A. (2004) Generation of transgenic cattle by lentiviral gene transfer into oocytes. Biol. Reprod. 71, 405-409.
Hogan B., Constantini F. and Lacy E. (1994) Manipulating the mouse embryo: a laboratory manual.
Hopkins A.L. and Groom C.R. (2002) The druggable genome. Nat. Rev. Drug Discov. 1, 727-730
Houdebine L.M. (2007) Transgenic animal models in biomedical research. Target discovery and validation reviews and protocols. 360, 163-202.
Huszar D., Lynch C.A., Fairchild-Huntress V., et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141.
Hutvagner G., McLachlan J., Pasquinelli A.E., et al. (2001) A cellular function for the RNAinterference enzyme Dicer in the maturation fo the let-7 small temporal RNA. Science 293, 834-838.
Jiang W., Zhou L., Breyer B., Feng T., Cheng H., Haydon R., Ishikawa A. and He T.C. (2001) Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cells. J. Biol. Chem. 276, 168-174.
Kataoka H., Shimomura T., Kawaguchi T., Hamasuna R., Itoh H., Kitamura N., Miyazawa K. and Koono M. (2000) Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in pericellular microenvironment. J. Biol. Chem. 275, 40453-40462
Kataoka H., Suganuma T., Shimomura T., Itoh H., Kitamura N., Nabeshima K. and Koono M. (1999) Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues: cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. J. Histochem. Cytochem. 47, 673-682
Kato M., Yamanouchi K., Ikawa M., et al. 1999. Efficient selection of transgenic mouse embryos using EGFP as a marker gene. Mol. Reprod. Dev. 54, 43-48.
Ketting R.F., Fisher S.E., Bernstein E., et al. (2001) Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654-2659.
Khvorova A., Reynolds A. and Jayasena S.D. (2003) Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216.
Kim V.N. (2005) MicroRNA biogenesis: coordinated cropping and dicing. Nat. Rev. Mol. Cell Biol. 6, 376-385
Kirchhofer D., Peek M., Lipari T., Billeci K., Fan B. and Moran P. (2005) Hepsin activates prohepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett. 579, 1945-1950
Kojima K., Tsuzukim S., Fushikim T. and Inouye K. (2008) Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase. J. Biol. Chem. 283, 2478-2487
Kondo A., Hirayama N., Sugito Y., Shono M., Tanaka T. and Kitamura N. (2008) Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. J. Biol. Chem. 283, 1428-1436
Kubisch H.M., Hernandez-Ledezma J.J., Larson M.A., Sikes J.D. and Roberts R.M. (1995) Expression of two transgenes in vitro matured and fertilized bovine zygotes after DNA microinjection. J. Reprod. Fertil. 104, 133-139.
Lee Y., Kim M., Han J., Yeom K.H., Lee S., Baek S.H. and Kim V.N. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 371-380.
Lewandski M. (2001) Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2, 743-755.
Lin C.Y., Anders, J., Johnson, M. and Dickson, R.B. (1999) Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. J. Biol. Chem. 274, 18237-18242
Lois C., Hong, E.J., Pease S., Brown E.J. and Baltimore D. (2004) Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295, 868-872.
Lund E., Guttinger S., Calad A., Dahlberg J.E. and Kutay U. (2004) Nuclear export of microRNA precursors. Science 303, 95-98.
Majumder S., Miranda M. and DePamphilis M.L. (1993) Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters. EMBO J. 12, 1131-1140.
Matsushima R., Takahashi A., Nakaya Y., Maezawa H., Miki M., Nakamura Y., Ohgushi F. and Yasuoka S. (2006) Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. Am. J. Physiol. Lung Cell Mol. Physiol. 290, L385-L395
McGrew M. J., Sherman A., Ellard F.M., et al. (2004) Efficient production of germline transgenic chickens using lentiviral vectors. EMBO Rep. 5, 728-733.
McManus M.T. and Sharp P.A. (2002) Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet. 3, 737-747.
Miyazawa K., Shimomura T., Naka D. and Kitamura N. (1994) Proteolytic activation of hepatocyte growth factor in response to tissue injury. J. Biol. Chem. 269, 8966-8970
Miyazawa K., Tsubouchi H., Naka D., Takahashi K., Okigaki M., Arakaki N., Nakayama H., Hirono S., Sakiyama O., Takahashi K., Gohda E., Daikuhara Y. and Kitamura N. (1989) Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem. Biophys. Res. Commun. 163, 967-973
Montes-Cobos E., Li X., Fischer H.J., et al. (2015) Inducible knock-down of the mineralocorticoid receptor in mice disturbs regulation of the Renin-Angiotensin-Aldosterone system and attenuates heart failure induced by pressure overload. PLoS ONE 10, e0143954.
Morgan E.A., McDaniel L.N., Yin T., et al., (2015) Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus. Diabetes 64, 1976-1987.
Moscona A. (2005) Oseltamivir resistance-disabling our influenza defenses. N. Engl. J. Med. 353, 2633–2636.
Mukai S., Fukushima T., Naka D., Tanaka H., Osada Y. and Kataoka H. (2008) Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1 related peptidases. FEBS J. 275, 1003-1017.
Myers K.P., Olsen C.W., and Gray G.C. (2007) Cases of swine influenza in humans: A review of the literature. Clin. Infect. Dis. 44, 1084-1088.
Nagaike K., Kawaguchi M., Takeda N., Fukushima T., Sawaguchi A., Kohama K., Setoyama M. and Kataoka H. (2008) Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/spint1) leads to ichthyosis-like condition and abnormal hair development in mice. Am. J. Pathol. 173, 1464-1475
Naito Y., Yamada T., Ui-Tei K., et al. (2004) siDirect, highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res. 32, W124-W129
Naka D., Ishii T., Yoshiyama Y., Miyazawa K., Hara H., Hishida T. and Kitamura N. (1992) Activation of hepatocyte growth factor by proteolytic conversion of a single-chain form to a heterodimer. J. Biol. Chem. 267, 20114-20119
Nakamura A., Okumura J. and Muramatsu T. (1998) Quantitative analysis of luciferase activity of viral and hybrid promoters in bovine preimplantation embryos. Mol. Reprod. Dev. 49, 368-373.
Niwa H., Yamamura K. and Miyazaki J. (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-199.
Oberst M.D., Chen L.-Y.L., Kiyomiya K., Williams C.A., Lee M.-S., Johnson M.D., Dickson R.B. and Lin C. (2005) HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. Am. J. Physiol. Cell Physiol. 289, C462-C470
Oberst M.D., Williams C.A., Dickson R.B., Johnson M.D. and Lin C.-Y. (2003) The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. J. Biol. Chem. 278, 26773-26779
Okabe M., Ikawa M., Kominami K., Nakanishi T. and Nishimune Y. (1997) “Green mice” as a soursce of ubiquitous green cells. FEBS Lett. 407, 313-319.
Okumura Y., Takahashi E., Yano M., Ohuchi M., Daidoji T., Nakaya T., Böttcher E., Garten W., Klenk H.D. and Kido H. (2010) Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avial influenza viruses and induce their multicycle replication. J. Virol. 84, 5089-5096.
Overington J.P., Al-Lazikani B. and Hopkins A.L. (2006) How many drug targets are there? Nat. Rev. Drug Discov. 5, 993-996.
Pinkert C.A. (2002) Transgenic Animal Technology. Academic, Orlando, FL. Podolska K. and Svoboda P. (2011) Targeting genes in living mammals by RNA interference. Briefings in Functional Genomics 10, 238-247.
Pracher D.C., Eckenrode V.K., Ward W.W., Prendergast F.G. and Cormier M.J. (1992) Primary structure of the Aequorea Victoria green-fluorescent protein. Gene 111, 229-233.
Rigby P.W., Dieckmann M., Rhodes C. and Berg P. (1977) Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113, 237-251
Rubin J.S., Chan A.M.-L., Bottaro D.P., Burgess W.H., Taylor W.G., Cech A.C., Hirschfield D.W., Wong J., Miki T., Finch P.W. and Aaronson S.A. (1991) A broad-spectrum human lung fibroblastderived mitogen is a variant of hepatocyte growth factor. Proc. Natl. Acad. Sci. USA 88, 415-419
Sasaki E., Suemizu H., Shimada A., Hanazawa K., Oiwa R., Kamioka M., Tomioka I., Sotomaru Y., Hirakawa R., Eto T., Shiozawa S., Maeda T., Ito M., Ito R., Kito C., Yagihashi C., Kawai K., Miyoshi H., Tanioka Y., Tamaoki N., Habu S., Okano H., and Nomura T. (2009) Generation of transgenic non-human primates with germline transmission. Nature 459, 523-528.
Scannel J.W., Blanckley A., Boldon H. and Warrington B. (2012) Diagnosing the decline in pharmaceutical R&D efficiency. Nat. Rev. Drug Discov. 11, 191-200
Scgwarz D.S., Hutvagner G., Du T., et al. (2003) Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208.
Sheu T.G., Fry A.M., Garten R.J., Deyde V.M., Shwe T., Bullion L. Peebles P.J., Li Y., Klimov A.I. and Gubareva L.V. (2011) Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010. J. Infect. Dis. 203, 13-17.
Shi Y. (2003) Mammalian RNAi for the masses. Trends Genet. 19, 9-12.
Shimomura T. and Kato M. (2008) New influenza therapeutic agent and/or prophylactic. patent,JP2008308438.
Shimomura T., Denda K., Kawaguchi T., Matsumoto K., Miyazawa K. and Kitamura N. (1999) Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. J. Biochem. 126, 821-828
Shimomura T., Denda K., Kitamura A., Kawaguchi T., Kito M., Kondo J., Kagaya S., Qin L., Takata H., Miyazawa K. and Kitamura N. (1997) Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J. Biol. Chem. 272, 6370-6376
Shimomura T., Ochiai M., Kondo J. and Morimoto Y. (1992) A novel protease obtained from FBS-containing culture supernatant, that processes single-chain form hepatocyte growth factor to two chain form in serum-free culture. Cytotechnology 8, 219-229
Shinagawa T. and Ishii S. (2003) Generation of Ski-knockdown mice by expressing a long doublestrand RNA from an RNA polymerase II promoter. Genes Dev. 17, 1340-1345.
Smith K.R. (2002) Gene transfer in higher animals: theoretical considerations and key concepts. J. Biotechnol. 99, 1-22.
Soe B.B., Kim C.H., Tojo H., Tanaka S., Yamanouchi K., Takahashi M., Sawasaki T. and Tachi C. (1997) Efficient selection of preimplantation transgenic embryos by an improved procedure using DpnI-Bal31 digestion and the polymerase chain reaction. Reprod. Fertil. Dev. 9, 263-269.
Sutton G.M., Trevaskis J.L., Hulver M.W., et al. (2006) Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147, 2183-2196.
Suzuki M., Kasai K. and Saeki Y. 2006. Plasmid DNA sequences present in conventional Herpes Simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin. J. Virol. 80, 3293-3300.
Szabo R., Molinolo A., List K. and Bugge T.H. (2007) Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene 26, 1546-1556
Szabo R., Wu Q., Dickson R.B., Netzel-Arnett S., Antalis T.M. and Bugge T.H. (2003) Type II transmembrane serine proteases. Thromb. Haemost. 90, 185-193
Takada T., Iida K., Awaji T., Itoh K., Takahashi R., Shibui A., Yoshida K., Sugano S. and Tsujimoto G. (1997) Selective production of transgenic mice using green fluorescent protein as a marker. Nature Biotech. 15, 468-461.
Takahashi M., Sano T., Yamaoka K., Kamimura T., Umemoto N., Nishitani H. and Yasuoka S. (2001) Localization of human airway trypsin-like protease in the airway: an immunohistochemical study. Histochem. Cell Biol. 115, 181-187
Takeda S. and Toyoda Y. (1991) Expression of SV40-lacZ gene in mouse preimplantation embryos after pronuclear microinjection. Mol. Reprod. Dev. 30, 90-94.
Tanaka H., Fukushima T., Yorita K., Kawaguchi M. and Kataoka H. (2009) Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells. Hum. Cell 22, 11-17
Tanaka H., Nagaike K., Takeda N., Itoh H., Kohama K., Fukushima T., Miyata S., Uchiyama S., Uchinokura S., Shimomura T., Miyazawa K., Kitamura N., Yamada G. and Kataoka H. (2005) Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantonic placenta. Mol. Cell. Biol. 25, 5687-5698
Tarran R., Trout L., Donaldson S.H. and Boucher R.C. (2006) Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia. J. Gen. Physiol. 127, 591-604
Thompson E.M., Adenot P., Tsuji F.I. and Renard J.P. (1995) Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreed luciferase. Proc. Natl. Acad. Sci.USA 92, 1317-1321.
Ueno K., Hiramoto Y., Hayashi S. and Kondoh H. (1987) Introduction and expression of recombinant β-galactosidase genes in cleavage stage mouse embryos. Dev. Growth Differ. 30, 61-73.
Ui-Tei K., Naito Y., Takahashi F., et al. (2004) Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32, 936-948.
Venter J.C., Adams M.D., Myers E.W., et al. (2001) The sequence of the human genome. Science 291, 1304-1351.
Wall R.J., Hawk H.W. and Nel N. (1992) Making transgenic livestock: Genetic engineering on a large scale. J. Cell. Biochem. 49, 113-120.
Wang Y., Medvid R., Melton C., et al. (2007) DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 39: 380-385.
Whitelaw C.B.A. (2004) Transgenic livestock made easy. Trends Biotechnol. 22, 157-159.
Wreschner D.H., McGuckin M.A., Williams S.J., Baruch A., Yoeli M., Ziv R., Okun L., Zaretsky J., Smorodinsky N., Keydar I., Neophytou P., Stacey M., Lin H.-H. and Gordon S. (2002) Generation of ligand-receptor alliances by “SEA” module-mediated cleavage of membraneassociated mucin proteins. Protein Sci. 11, 698-706
Yamaoka K., Masuda K., Ogawa H., Takagi K., Umemoto N. and Yasuoka S. (1998) Cloning and characterization of the cDNA for human airway trypsin-like protease. J. Biol. Chem. 273, 11895-11901
Yang H., Wang H. and Jaenisch R. (2014) Generating genetically modified mice using CRISPR/Cas-mediated genome engineering. Nat. Protoc. 9, 1956-1968.
Yasuoka S., Ohnishi T., Kawano S., Tsuchihashi S., Ogawara M., Masuda K., Yamaoka K., Takahashi M. and Sano T. (1997) Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. Am. J. Respir. Cell Mol. Biol. 16, 300-308
Yekta S., Shih I.H. and Bartel D.P. (2004) MicroRNA-directed cleavage of HOXB8 mRNA. Science 304, 594-496.
Yi R., Qin Y., Macara I.G. and Cullen B.R. (2003) Exportin-5 mediates the nuclear export of premicroRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016.
Yue J., Sheng Y., Ren A. and Penmatsa S. (2010) A miR-21 hairpin structure-based gene knockdown vector. Biochem. Biophys. Res. Commun. 394, 667-672
Zeng Y., Yi R. and Cullen B.R. (2003) MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl. Acad. Sci. USA 100, 9779-9784.
Zhou H., Xia X.G. and Xu Z. (2005) An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucl. Acids Res. 33, e62.
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