Studies on the functional roles of structural dynamics mediated by intrinsically disordered proteins

概要

Ꮫ఩ㄽᩥせ⣙
Studies on the functional roles of structural dynamics
mediated by intrinsically disordered proteins
㸦ኳ↛ኚᛶࢱࣥࣃࢡ㉁࡟ࡼࡿᵓ㐀ືែࡢᶵ⬟ୖࡢᙺ๭ࡢ◊✲㸧

ᕝᔘ ு♸
Department of Mathematical and Life Sciences,
Graduate School of Science,
Hiroshima University

Content of the thesis
General Introduction
Chapter Ⅰ
Dynamic allostery modulates catalytic activity by modifying the hydrogen
bonding network in the catalytic site of human Pin1
Chapter Ⅱ Multi-domain protein, Pin1 enhances the bivalent binding affinity through
the inter-domain communication
Chapter Ⅲ Transiently extended conformation of the intrinsically disordered protein,
Tau is strengthened by the P301L mutation
General conclusion
Acknowledgments
References