1 Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, J.-i., Ohtani, M., Fujii, H., and Koyasu, S. 2009. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463:540.
2 Xue, L., Salimi, M., Panse, I., Mjösberg, J. M., McKenzie, A. N., Spits, H., Klenerman, P., and Ogg, G. 2014. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. J Allergy Clin Immunol 133:1184.
3 Klose, C. S. N., Mahlakõiv, T., Moeller, J. B., Rankin, L. C., Flamar, A. L., Kabata, H., Monticelli, L. A., Moriyama, S., Putzel, G. G., Rakhilin, N., Shen, X., Kostenis, E., König, G. M., Senda, T., Carpenter, D., Farber, D. L., and Artis, D. 2017. The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature 549:282.
4 Wallrapp, A., Riesenfeld, S. J., Burkett, P. R., Abdulnour, R. E., Nyman, J., Dionne, D., Hofree, M., Cuoco, M. S., Rodman, C., Farouq, D., Haas, B. J., Tickle, T. L., Trombetta, J. J., Baral, P., Klose, C. S. N., Mahlakõiv, T., Artis, D., Rozenblatt-Rosen, O., Chiu, I. M., Levy, B. D., Kowalczyk, M. S., Regev, A., and Kuchroo, V. K. 2017. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature 549:351.
5 Laffont, S., Blanquart, E., Savignac, M., Cénac, C., Laverny, G., Metzger, D., Girard, J. P., Belz, G. T., Pelletier, L., Seillet, C., and Guéry, J. C. 2017. Androgen signaling negatively controls group 2 innate lymphoid cells. J Exp Med 214:1581.
6 Cardoso, V., Chesné, J., Ribeiro, H., García-Cassani, B., Carvalho, T., Bouchery, T., Shah, K., Barbosa-Morais, N. L., Harris, N., and Veiga-Fernandes, H. 2017. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature 549:277.
7 Doherty, T. A., Khorram, N., Chang, J. E., Kim, H. K., Rosenthal, P., Croft, M., and Broide, D. H. 2012. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria. Am J Physiol Lung Cell Mol Physiol 303:L577.
8 Halim, T. Y., Krauss, R. H., Sun, A. C., and Takei, F. 2012. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36:451.
9 Brestoff, J. R., Kim, B. S., Saenz, S. A., Stine, R. R., Monticelli, L. A., Sonnenberg, G. F., Thome, J. J., Farber, D. L., Lutfy, K., Seale, P., and Artis, D. 2015. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519:242.
10 Lee, M.-W., Odegaard, Justin I., Mukundan, L., Qiu, Y., Molofsky, Ari B., Nussbaum, Jesse C., Yun, K., Locksley, Richard M., and Chawla, A. 2015. Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis. Cell 160:74.
11 Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G., Doering, T. A., Angelosanto, J. M., Laidlaw, B. J., Yang, C. Y., Sathaliyawala, T., Kubota, M., Turner, D., Diamond, J. M., Goldrath, A. W., Farber, D. L., Collman, R. G., Wherry, E. J., and Artis, D. 2011. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol 12:1045.
12 Dalmas, E., Lehmann, F. M., Dror, E., Wueest, S., Thienel, C., Borsigova, M., Stawiski, M., Traunecker, E., Lucchini, F. C., Dapito, D. H., Kallert, S. M., Guigas, B., Pattou, F., Kerr-Conte, J., Maechler, P., Girard, J. P., Konrad, D., Wolfrum, C., Böni-Schnetzler, M., Finke, D., and Donath, M. Y. 2017. Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production. Immunity 47:928.
13 Hoyler, T., Klose, C. S., Souabni, A., Turqueti-Neves, A., Pfeifer, D., Rawlins, E. L., Voehringer, D., Busslinger, M., and Diefenbach, A. 2012. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37:634.
14 Gasteiger, G., Fan, X., Dikiy, S., Lee, S. Y., and Rudensky., A. Y. 2015. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 350:981.
15 Moro, K., Kabata, H., Tanabe, M., Koga, S., Takeno, N., Mochizuki, M., Fukunaga, K., Asano, K., Betsuyaku, T., and Koyasu, S. 2016. Interferon and IL- 27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nat Immunol 17:76.
16 Koga, S., Hozumi, K., Hirano, K. I., Yazawa, M., Terooatea, T., Minoda, A., Nagasawa, T., Koyasu, S., and Moro, K. 2018. Peripheral PDGFRalpha(+)gp38(+) mesenchymal cells support the differentiation of fetal liver-derived ILC2. J Exp Med 215:1609.
17 Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., and Martin, T. J. 1999. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345.
18 Fumoto, T., Takeshita, S., Ito, M., and Ikeda, K. 2014. Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasis. J Bone Miner Res 29:830.
19 Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-Hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., Penninger, J. M., and Takayanagi, H. 2011. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 17:1231.
20 Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., and Suda, T. 1988. Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600.
21 Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., and Takayanagi, H. 2017. Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems. Physiol Rev 97:1295.
22 Fujiwara, Y., Piemontese, M., Liu, Y., Thostenson, J. D., Xiong, J., and O'Brien, C. A. 2016. RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice. J Biol Chem 291:24838.
23 Rauber, S., Luber, M., Weber, S., Maul, L., Soare, A., Wohlfahrt, T., Lin, N. Y., Dietel, K., Bozec, A., Herrmann, M., Kaplan, M. H., Weigmann, B., Zaiss, M. M., Fearon, U., Veale, D. J., Canete, J. D., Distler, O., Rivellese, F., Pitzalis, C., Neurath, M. F., McKenzie, A. N. J., Wirtz, S., Schett, G., Distler, J. H. W., and Ramming, A. 2017. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med 23:938.
24 Omata, Y., Frech, M., Primbs, T., Lucas, S., Andreev, D., Scholtysek, C., Sarter, K., Kindermann, M., Yeremenko, N., Baeten, D. L., Andreas, N., Kamradt, T., Bozec, A., Ramming, A., Kronke, G., Wirtz, S., Schett, G., and Zaiss, M. M. 2018. Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep 24:169.
25 Omata, Y., Frech, M., Lucas, S., Primbs, T., Knipfer, L., Wirtz, S., Kadono, Y., Saito, T., Tanaka, S., Sarter, K., Schett, G., and Zaiss, M. M. 2020. Type 2 innate lymphoid cells inhibit the differentiation of osteoclasts and protect from ovariectomy-induced bone loss. Bone 136:115335.
26 Kikuta, J., Wada, Y., Kowada, T., Wang, Z., Sun-Wada, G. H., Nishiyama, I., Mizukami, S., Maiya, N., Yasuda, H., Kumanogoh, A., Kikuchi, K., Germain, R. N., and Ishii, M. 2013. Dynamic visualization of RANKL and Th17-mediated osteoclast function. J Clin Invest 123:866.
27 Furuya, M., Kikuta, J., Fujimori, S., Seno, S., Maeda, H., Shirazaki, M., Uenaka, M., Mizuno, H., Iwamoto, Y., Morimoto, A., Hashimoto, K., Ito, T., Isogai, Y., Kashii, M., Kaito, T., Ohba, S., Chung, U. I., Lichtler, A. C., Kikuchi, K., Matsuda, H., Yoshikawa, H., and Ishii, M. 2018. Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo. Nat Commun 9:300.
28 Hong, Y. S., Moon, S. J., Joo, Y. B., Jeon, C. H., Cho, M. L., Ju, J. H., Oh, H. J., Heo, Y. J., Park, S. H., Kim, H. Y., and Min, J. K. 2011. Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci 26:1132.
29 Matsuyama, Y., Okazaki, H., Tamemoto, H., Kimura, H., Kamata, Y., Nagatani, K., Nagashima, T., Hayakawa, M., Iwamoto, M., Yoshio, T., Tominaga, S., and Minota, S. 2010. Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis. The Journal of rheumatology 37:18.
30 Kanzaki, H., Makihira, S., Suzuki, M., Ishii, T., Movila, A., Hirschfeld, J., Mawardi, H., Lin, X., Han, X., Taubman, M. A., and Kawai, T. 2016. Soluble RANKL Cleaved from Activated Lymphocytes by TNF-α-Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis. J Immunol 197:3871.
31 Asano, T., Okamoto, K., Nakai, Y., Tsutsumi, M., Muro, R., Suematsu, A., Hashimoto, K., Okamura, T., Ehata, S., Nitta, T., and Takayanagi, H. 2019. Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone. Nat Metab 1:868.
32 Palmqvist, P., Lundberg, P., Persson, E., Johansson, A., Lundgren, I., Lie, A., Conaway, H. H., and Lerner, U. H. 2006. Inhibition of hormone and cytokine- stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway. J Biol Chem 281:2414.
33 Atanga, E., Dolder, S., Dauwalder, T., Wetterwald, A., and Hofstetter, W. 2011. TNFα inhibits the development of osteoclasts through osteoblast-derived GM- CSF. Bone 49:1090.
34 Gong, L., Zhao, Y., Zhang, Y., and Ruan, Z. 2016. The Macrophage Polarization Regulates MSC Osteoblast Differentiation in vitro. Ann Clin Lab Sci 46:65.
35 Zhang, Y., Böse, T., Unger, R. E., Jansen, J. A., Kirkpatrick, C. J., and van den Beucken, J. J. J. P. 2017. Macrophage type modulates osteogenic differentiation of adipose tissue MSCs. Cell and Tissue Research 369:273.
36 Wilhelm, C., Kharabi Masouleh, S., and Kazakov, A. 2017. Metabolic Regulation of Innate Lymphoid Cell-Mediated Tissue Protection—Linking the Nutritional State to Barrier Immunity. Frontiers in Immunology 8.
37 Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Jr., Wang, J., Ramalingam, T. R., Bhandoola, A., Wynn, T. A., and Belkaid, Y. 2014. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 343:432.
38 Melhus, H., Michaëlsson, K., Kindmark, A., Bergström, R., Holmberg, L., Mallmin, H., Wolk, A., and Ljunghall, S. 1998. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Annals of internal medicine 129:770.
39 Weitzmann, M. N., Roggia, C., Toraldo, G., Weitzmann, L., and Pacifici, R. 2002. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 110:1643.
40 Toraldo, G., Roggia, C., Qian, W. P., Pacifici, R., and Weitzmann, M. N. 2003. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A 100:125.
41 Wang, X., Liang, T., Zhu, Y., Qiu, J., Qiu, X., Lian, C., Gao, B., Peng, Y., Liang, A. , Zhou, H., Yang, X., Liao, Z., Li, Y., Xu, C., Su, P., and Huang, D. 2019. Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis. Mol Med 25:43.
42 Lind, T., Sundqvist, A., Hu, L., Pejler, G., Andersson, G., Jacobson, A., and Melhus, H. 2013. Vitamin a is a negative regulator of osteoblast mineralization. PLoS One 8:e82388.
43 Yang, Q., Ge, M. Q., Kokalari, B., Redai, I. G., Wang, X., Kemeny, D. M., Bhandoola, A., and Haczku, A. 2016. Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 137:571.
44 Ricardo-Gonzalez, R. R., Van Dyken, S. J., Schneider, C., Lee, J., Nussbaum, J. C., Liang, H. E., Vaka, D., Eckalbar, W. L., Molofsky, A. B., Erle, D. J., and Locksley, R. M. 2018. Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol 19:1093.
45 Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K. A., Bucks, C., Kane, C. M., Fallon, P. G., Pannell, R., Jolin, H. E., and McKenzie, A. N. J. 2010. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464:1367.
46 Ikutani, M., Yanagibashi, T., Ogasawara, M., Tsuneyama, K., Yamamoto, S., Hattori, Y., Kouro, T., Itakura, A., Nagai, Y., Takaki, S., and Takatsu, K. 2012. Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol 188:703.
47 Nussbaum, J. C., Van Dyken, S. J., von Moltke, J., Cheng, L. E., Mohapatra, A., Molofsky, A. B., Thornton, E. E., Krummel, M. F., Chawla, A., Liang, H. E., and Locksley, R. M. 2013. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502:245.
48 Sawa, S., Lochner, M., Satoh-Takayama, N., Dulauroy, S., Bérard, M., Kleinschek, M., Cua, D., Di Santo, J. P., and Eberl, G. 2011. RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 12:320.
49 Bando, J. K., Gilfillan, S., Song, C., McDonald, K. G., Huang, S. C., Newberry, R. D., Kobayashi, Y., Allan, D. S. J., Carlyle, J. R., Cella, M., and Colonna, M. 2018. The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells. Immunity 48:1208.
50 Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y., and Suda, T. 2005. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med 202:345.
51 Miyamoto, H., Suzuki, T., Miyauchi, Y., Iwasaki, R., Kobayashi, T., Sato, Y., Miyamoto, K., Hoshi, H., Hashimoto, K., Yoshida, S., Hao, W., Mori, T., Kanagawa, H., Katsuyama, E., Fujie, A., Morioka, H., Matsumoto, M., Chiba, K., Takeya, M., Toyama, Y., and Miyamoto, T. 2012. Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells. J Bone Miner Res 27:1289.
52 Kukita, T., Wada, N., Kukita, A., Kakimoto, T., Sandra, F., Toh, K., Nagata, K., Iijima, T., Horiuchi, M., Matsusaki, H., Hieshima, K., Yoshie, O., and Nomiyama, H. 2004. RANKL-induced DC-STAMP is essential for osteoclastogenesis. J Exp Med 200:941.
53 Kim, M. H., Park, M., Baek, S. H., Kim, H. J., and Kim, S. H. 2011. Molecules and signaling pathways involved in the expression of OC-STAMP during osteoclastogenesis. Amino Acids 40:1447.
54 Conaway, H. H., Pirhayati, A., Persson, E., Pettersson, U., Svensson, O., Lindholm, C., Henning, P., Tuckermann, J., and Lerner, U. H. 2011. Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem 286:31425.
55 Kim, K. W., Cho, M. L., Lee, S. H., Oh, H. J., Kang, C. M., Ju, J. H., Min, S. Y., Cho, Y. G., Park, S. H., and Kim, H. Y. 2007. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunology letters 110:54.
56 Kim, K. W., Cho, M. L., Oh, H. J., Kim, H. R., Kang, C. M., Heo, Y. M., Lee, S. H., and Kim, H. Y. 2009. TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis. Immunology letters 124:9.
57 Mantovani, A., Sozzani, S., Locati, M., Allavena, P., and Sica, A. 2002. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549.
58 Gordon, S. 2003. Alternative activation of macrophages. Nat Rev Immunol 3:23.
59 Li, Y., Kong, N., Li, Z., Tian, R., Liu, X., Liu, G., Wang, K., and Yang, P. 2019. Bone marrow macrophage M2 polarization and adipose-derived stem cells osteogenic differentiation synergistically promote rehabilitation of bone damage. Journal of cellular biochemistry 120:19891.
60 Zaiss, M. M., Kurowska-Stolarska, M., Bohm, C., Gary, R., Scholtysek, C., Stolarski, B., Reilly, J., Kerr, S., Millar, N. L., Kamradt, T., McInnes, I. B., Fallon, P. G., David, J. P., Liew, F. Y., and Schett, G. 2011. IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF- -Mediated Bone Loss. The Journal of Immunology 186:6097.
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