論文の公開元へ重症TAFRO症候群2症例に対する運動療法の負荷量の検討(症例報告）
概要
After the onset of severe thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome, we performed exercise therapy for 2 patients with weakness of the limbs. During exercise the muscular strength of the lower limbs, as determined with manual muscle testing, was poor in both patients, and the activities of daily living received Barthel Index scores of 0. Starting from bed support, the exercise load of the 2 patients was increased or decreased as the blood test results improved. Although the recovery courses of the 2 patients differed, both patients were able to leave their homes by walking on their own. A review of the recovery course of physical function and test results showed a correlation with the recovery of muscle strength and the levels of platelets and alkaline phosphatase. Although the pathophysiology of TAFRO syndrome is still unknown, we believe that appropriate exercise therapy should be considered because muscle weakness can easily be caused by corticosteroid therapy and long-term bed rest. In addition, our findings suggest the usefulness of examining the increase or decrease of exercise load on the basis of the progression of platelet and alkaline phosphatase levels in patients with TAFRO syndrome.
