リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat

Takahashi Yu 三重大学

2020.12.16

概要

Adiponectin is a plasma protein predominantly derived from adipocytes. Adiponectin has beneficial properties against diabetes, cardiovascular diseases, and cancer. In experimental acute cerebral ischemia, adiponectin accumulates on vessels in ischemic lesions and has anti-inflammatory protective effects. Chronic cerebral hypoperfusion is associated with white matter lesions and risk of dementia. Chronic cerebral hypoperfusion induced by permanent occlusion of the bilateral common carotid artery can experimentally produce cerebrovascular white matter lesions in the rat brain. Microglia are activated shortly after ischemia and correlate with the severity of white matter and hippocampal tissue damage. These data suggest that the inflammatory response selectively increases white matter and hippocampal damage during chronic cerebral hypoperfusion. However, factors protecting the cerebral cortex have not been elucidated. To clarify the role of adiponectin, we investigated possible changes in adiponectin and adiponectin receptor 1 (ADR1) in the brains of rats under chronic cerebral hypoperfusion. Adiponectin accumulated on the vessels predominantly in the cerebral cortex under chronic cerebral hypoperfusion. Adiponectin accumulation was not detected in the white matter or hippocampus. In the cerebral cortex, the number of ADR1-immunopositive vessels was increased, and adiponectin was colocalized with ADR1. It is plausible that accumulation of adiponectin may be mediated by the binding of adiponectin to ADR1, and its accumulation in the cerebral cortex may protect tissue injury by inhibiting inflammation under chronic cerebral hypoperfusion.

参考文献

1 Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes

and vascular function. J Clin Endocrinol Metab 2004; 89:2563–2568.

2 Fang H, Judd RL. Adiponectin regulation and function. Compr Physiol

2018; 8:1031–1063.

3 Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, et al.

Structure-function studies of the adipocyte-secreted hormone acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem

2003; 278:9073–9085.

4 Thundyil J, Pavlovski D, Sobey CG, Arumugam TV. Adiponectin receptor

signalling in the brain. Br J Pharmacol 2012; 165:313–327.

5 Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.

Improved ELISA for selective measurement of adiponectin multimers and

identification of adiponectin in human cerebrospinal fluid. Clin Chem 2007;

53:1541–1544.

6 Chen MP, Tsai JC, Chung FM, Yang SS, Hsing LL, Shin SJ, et al.

Hypoadiponectinemia is associated with ischemic cerebrovascular disease.

Arterioscler Thromb Vasc Biol 2005; 25:821–826.

7 Efstathiou SP, Tsioulos DI, Tsiakou AG, Gratsias YE, Pefanis AV,

Mountokalakis TD. Plasma adiponectin levels and five-year survival after

first-ever ischemic stroke. Stroke 2005; 36:1915–1919.

8 Chen B, Liao WQ, Xu N, Xu H, Wen JY, Yu CA, et al. Adiponectin protects

against cerebral ischemia-reperfusion injury through anti-inflammatory

action. Brain Res 2009; 1273:129–137.

9 Yatomi K, Miyamoto N, Komine-Kobayashi M, Liu M, Oishi H, Arai H, et al.

Pathophysiological dual action of adiponectin after transient focal ischemia

in mouse brain. Brain Res 2009; 1297:169–176.

10 Teixeira AL, Diniz BS, Campos AC, Miranda AS, Rocha NP, Talib LL, et al.

Decreased levels of circulating adiponectin in mild cognitive impairment

and Alzheimer’s disease. Neuromolecular Med 2013; 15:115–121.

11 Une K, Takei YA, Tomita N, Asamura T, Ohrui T, Furukawa K, Arai H.

Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer’s

disease. Eur J Neurol 2011; 18:1006–1009.

12 Wakita H, Tomimoto H, Akiguchi I, Kimura J. Glial activation and white

matter changes in the rat brain induced by chronic cerebral hypoperfusion:

an immunohistochemical study. Acta Neuropathol 1994; 87:484–492.

13 Wakita H, Ruetzler C, Illoh KO, Chen Y, Takanohashi A, Spatz M,

Hallenbeck JM. Mucosal tolerization to E-selectin protects against memory

dysfunction and white matter damage in a vascular cognitive impairment

model. J Cereb Blood Flow Metab 2008; 28:341–353.

14 Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery

occlusion in the rat: a model for chronic cerebral hypoperfusion-related

neurodegenerative diseases. Brain Res Rev 2007; 54:162–180.

15 Bang J, Jeon WK, Lee IS, Han JS, Kim BY. Biphasic functional regulation

in hippocampus of rat with chronic cerebral hypoperfusion induced by

permanent occlusion of bilateral common carotid artery. Plos One 2013;

8:e70093.

16 Mizutani K, Sonoda S, Yamada K, Beppu H, Shimpo K. Alteration of protein

expression profile following voluntary exercise in the perilesional cortex of

rats with focal cerebral infarction. Brain Res 2011; 1416:61–68.

17 Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al.

Adiponectin stimulates angiogenesis by promoting cross-talk between

AMP-activated protein kinase and akt signaling in endothelial cells. J Biol

Chem 2004; 279:1304–1309.

18 Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin

stimulates production of nitric oxide in vascular endothelial cells. J Biol

Chem 2003; 278:45021–45026.

Copyright © 2019 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.

8 NeuroReport 2019, Vol XXX No XXX

19 Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, Kudo C, et al.

Adiponectin prevents cerebral ischemic injury through endothelial nitric

oxide synthase dependent mechanisms. Circulation 2008; 117:

216–223.

20 Otori T, Katsumata T, Muramatsu H, Kashiwagi F, Katayama Y, Terashi

A. Long-term measurement of cerebral blood flow and metabolism in

a rat chronic hypoperfusion model. Clin Exp Pharmacol Physiol 2003;

30:266–272.

21 Xu N, Zhang Y, Doycheva DM, Ding Y, Zhang Y, Tang J, et al. Adiponectin

attenuates neuronal apoptosis induced by hypoxia-ischemia via the

activation of adipor1/APPL1/LKB1/AMPK pathway in neonatal rats.

Neuropharmacology 2018; 133:415–428.

22 Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, Hough K, et al.

Adiponectin deficiency increases leukocyte-endothelium interactions via

upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest

2007; 117:1718–1726

Copyright © 2019 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.

AUTHOR QUERY FORM

LIPPINCOTT

WILLIAMS AND WILKINS

JOURNAL NAME: WNR

ARTICLE NO: NR-D-19-01101

QUERIES AND / OR REMARKS

QUERY NO.

Details Required

Q1

 or indexing purposes, please confirm

that author names have been correctly

identified as given names (blue) and

surnames (red). Color in the byline

will not appear on the final published

version.

Q2

Kindly confirm the ‘conflicts of interest’

statement.

Author’s Response

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る