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Acknowledgements
This work was supported by a JSPS Grant-in-Aid for Scientific Research (19H01026 to KH), the Takeda Science
Foundation (KH), the Mochida Memorial Foundation for Medical and Pharmaceutical Research (KH), and the
Uehara Memorial Foundation (KH).
Author contributions
Y.T. and K.H. designed the study. Y.T., D.O., H.W., G.K., and K.H. performed the experiments. N.S., S.S., A.M.,
and T.M. provided intellectual input. Y.T. and K.H. wrote the manuscript. K.H. supervised the project. All authors
reviewed the manuscript.
Competing interests The authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.org/
10.1038/s41598-021-98145-y.
Correspondence and requests for materials should be addressed to K.H.
Reprints and permissions information is available at www.nature.com/reprints.
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