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大学・研究所にある論文を検索できる 「Fourth mRNA vaccination increases cross-neutralizing antibody titers against SARS-CoV-2 variants, including BQ.1.1 and XBB, in a very elderly population」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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Fourth mRNA vaccination increases cross-neutralizing antibody titers against SARS-CoV-2 variants, including BQ.1.1 and XBB, in a very elderly population

Sutandhio, Silvia Furukawa, Koichi Kurahashi, Yukiya Marini, Maria Istiqomah Effendi, Gema Barlian Hasegawa, Natsumi Ishimaru, Hanako Nishimura, Mitsuhiro Arii, Jun Mori, Yasuko 神戸大学

2023.07

概要

Background: Omicron variants with immune evasion have emerged, and they continue to mutate rapidly, raising concerns about the weakening of vaccine efficacy, and the very elderly populations are vulnerable to Coronavirus Disease 2019 (COVID-19). Therefore, to investigate the effect of multiple doses of mRNA vaccine for the newly emerged variants on these populations, cross-neutralizing antibody titers were examined against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants, including BQ.1.1 and XBB. Methods: Blood samples were taken from residents at four long-term care facilities in Hyogo prefecture, Japan (median age, 91 years), after 3rd (n = 67) and 4th (n = 48) mRNA vaccinations, from April to October 2022. A live virus microneutralization assay was performed to determine the neutralizing antibody titers in participants’ sera. Results: After 3rd vaccination, cross-neutralizing antibody prevalence against conventional (D614G) virus, Delta, Omicron BA.2, BA.5, BA.2.75, BQ.1.1, and XBB were 100%, 97%, 81%, 51%, 67%, 4%, and 21%, respectively. After 4th vaccination, the antibody positivity rates increased to 100%, 100%, 98%, 79%, 92%, 31%, and 52%, respectively. The 4th vaccination significantly increased cross-neutralizing antibody titers against all tested variants. Conclusion: The positivity rates for BQ.1.1 and XBB increased after 4th vaccination, although the titer value was lower than those of BA.5 and BA.2.75. Considering the rapid mutation of viruses and the efficacy of vaccines, it may be necessary to create a system that can develop vaccines suitable for each epidemic in consideration of the epidemic of the virus.

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参考文献

All authors contributed to the concept of this article. SS drafted

the manuscript, and YM revised the manuscript. KF collected sam­

ples. SS, KF, YK, MIM, GBE, NH, and HI performed experiments. SS,

KF, HI, MN, JA, and YM analyzed the data. YM supervised experi­

ments. YM oversaw the project. All authors approved the final ver­

sion of the manuscript.

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Funding

This work was supported by the Hyogo Prefectural Government

for YM, and JSPS KAKENHI Grant-in-Aid for Research Activity Startup (Grant Number 22K21115) for HI. The funders had no role in this

study.

Declaration of Competing Interest

This statement is to certify that all Authors have seen and ap­

proved the manuscript being submitted. We warrant that the article

is the Authors’ original work. We warrant that the article has not

received prior publication and is not under consideration for pub­

lication elsewhere. On behalf of all Co-Authors, the corresponding

Author shall bear full responsibility for the submission.

This research has not been submitted for publication nor has it

been published in whole or in part elsewhere. We attest to the fact

that all Authors listed on the title page have contributed significantly

to the work, have read the manuscript, attest to the validity and

legitimacy of the data and its interpretation, and agree to its sub­

mission to the Journal of Infection and Public Health.

All authors agree that author list is correct in its content and

order and that no modification to the author list can be made

without the formal approval of the Editor-in-Chief, and all authors

accept that the Editor-in-Chiefs decisions over acceptance or rejec­

tion or in the event of any breach of the Principles of Ethical

Publishing in the Journal of lnfection and Public Health being dis­

covered of retraction are final.

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