多発性硬化症における遺伝的要因

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（特に重要な文献については，番号をゴシック体で表記している．）

多発性硬化症における遺伝的要因

175

Genetic Factors Associated with Multiple Sclerosis

Noriko ISOBE

Department of Neurology, Graduate School of Medical Sciences,

Kyushu University, Fukuoka 812-8582, Japan

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease of central nervous system. It mainly

affects women in their twenties to forties. MS is one of complex diseases that both genetic and

environmental factors contribute for the pathogenesis. Recent international collaborative study

revealed more than 200 genetic variants derived from both the major histocompatibility complex

(MHC) region and multiple non-MHC regions as well as various environmental factors. Cumulative

statistics have been often developed to return genetic data to each individual and describe the patterns

how much genetic factors accumulate into a single score. So far the genetic risk accumulation will not

predict the susceptibility for MS precisely but such strategy is to be developed in the near future.

Key words : multiple sclerosis, HLA, SNP, personalized medicine

著者プロフィール

磯部 紀子（いそべ のりこ）

九州大学教授（大学院医学研究院神経内科学）．医学博士．

◆略歴 1978 年佐賀県に生まれる．2003 年九州大学医学部医学科卒業．2010 年同大学院早期修了．

2010 年 10 月〜2017 年 3 月米国カリフォルニア大学サンフランシスコ校神経内科学教室研

究留学．2017 年九州大学大学院医学研究院脳神経治療学准教授，2020 年同大学院医学研究

院神経内科学特任准教授．2021 年 3 月より現職．

◆研究テーマと抱負 多発性硬化症を中心とする中枢神経系自己免疫性疾患における発症や表現型

に寄与する遺伝的・環境要因の解明に従事．患者の背景因子やバイオマーカーによる個別

化医療の実現を目指す．

◆趣味 旅行

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