Baba, S., Vakorin, V.A., Doesburg, S.M., Nagamori, C., Cortez, M.A., Honda, R., Ono, T.,
TodaK, Nishimoto H, Ebihara, T., Sakai, K., Ochi, A., Snead 3rd, O.C., Baba, H.,
Otsubo, H., 2019. EEGbefore and after total corpus callosotomy for
pharmacoresistant infantile spasms:Fast oscillations and slow-wave connectivity in
hypsarrhythmia. Epilepsia 60, 1849–1860.
De Herdt, V., Boon, P., Ceulemans, B., Hauman, H., Lagae, L., Legros, B., Sadzot, B.,
VanBogaert, P., van Rijckevorsel, K., Verhelst, H., Vonck, K., 2007. Vagus nerve
stimulation forrefractory epilepsy: a Belgian multicenter study. Eur J Paediatr
Neurol 11 (261-9). Epub 2007 Mar 28.
Englot, D.J., Chang, E.F., Auguste, K.I., 2011. Vagus nerve stimulation for epilepsy: a
meta-analysis of efficacy and predictors of response. J Neurosurg 115, 1248–1255.
Englot, D.J., Rolston, J.D., Wright, C.W., Hassnain, K.H., Chang, E.F., 2016. Rates and
Predictors of Seizure Freedom With Vagus Nerve Stimulation for Intractable
Epilepsy. Neurosurgery 79, 345–353.
Frauscher, B., von Ellenrieder, N., Dubeau, F., Gotman, J., 2016. EEG desynchronization
during phasic REM sleep suppresses interictal epileptic activity in humans. Epilepsia
57, 879–888.
Hal´
asz, P., B´
odizs, R., Ujma, P.P., Fab´
o, D., Sz˝
ucs, A., 2019. Strong relationship between
NREM sleep, epilepsy and plastic functions - A conceptual review on the
neurophysiology background. Epilepsy Res 150, 95–105.
Hashizume, A., Iida, K., Shirozu, H., Hanaya, R., Kiura, Y., Kurisu, K., Otsubo, H., 2007.
Gradient magnetic-field topography for dynamic changes of epileptic discharges.
Brain Res 1144 (175-9). Epub 2007 Feb 7.
Iida, K., Otsubo, H., Mohamed, I.S., Okuda, C., Ochi, A., Weiss, S.K., Chuang, S.H.,
Snead 3rd, O.C., 2005. Characterizing magnetoencephalographic spike sources in
children with tuberous sclerosis complex. Epilepsia 46, 1510–1517.
Kagawa, K., Iida, K., Hashizume, A., Katagiri, M., Baba, S., Kurisu, K., Otsubo, H., 2016.
Magnetoencephalography using gradient magnetic field topography (GMFT) can
predict successful anterior corpus callosotomy in patients with drop attacks. Clin
Neurophysiol 127, 221–229.
Katagiri, M., Iida, K., Ishihara, K., Nair, D., Harada, K., Kagawa, K., Seyama, G.,
Hashizume, A., Kuramoto, T., Hanaya, R., Arita, K., Kurisu, K., 2019. Anti-seizure
effect and neuronal activity change in the genetic-epileptic model rat with acute and
chronic vagus nerve stimulation. Epilepsy Res 155, 106159.
Lourie, H., Uemura, K., 1965. Psychomotor seizures and mirror focus secondary to
retained knife blade in temporal lobe. Resolution of mirror focus after extirpation of
prmary lesion. J Neurosurg 22, 602–606.
Maehara, T., Shimizu, H., 2001. Surgical outcome of corpus callosotomy in patients with
drop attacks. Epilepsia 42, 67–71.
McHugh, J.C., Singh, H.W., Phillips, J., Murphy, K., Doherty, C.P., Delanty, N., 2007.
Outcome measurement after vagal nerve stimulation therapy: proposal of a new
classification. Epilepsia 48, 375–378.
Morrell, F., 1985. Secondary epileptogenesis in man. Arch Neurol 42, 318–335.
Morrell, F., 1989. Varieties of human secondary epileptogenesis. J Clin Neurophysiol 6,
227–275.
Morris 3rd, G.L., Mueller, W.M., 1999. Long-term treatment with vagus nerve
stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study
GroupE01-E05. Neurology 53, 1712.
Oguni, H., Olivier, A., Andermann, F., Comair, J., 1991. Anterior callosotomy in the
treatment of medically intractable epilepsies: a study of 43 patients with a mean
follow-up of 39 months. Ann Neurol 30, 357–364.
Okanari, K., Baba, S., Otsubo, H., Widjaja, E., Sakuma, S., Go, C.Y., Jones, K.C.,
Nishioka, K., Oba, S., Matsui, T., Ueno, M., Ukitsu, S., Rutka, J.T., Drake, J.M.,
4.5. Limitations and future directions
This study has several limitations. (1) the number of cases was
inevitably limited in the number of patients with VNS that had pre- and
post-MEG. We routinely performed MEG prior to VNS. However, the
majority of patients with VNS did not participate in our study because
their VNS device was metallic, limiting MEG. (2) the timing of post-VNS
MEG was inconsistent.
Further study of post-VNS MEG to collect more cases and improve
our analysis is warranted. Moreover, the timing of post-VNS MEG
evaluation could be performed uniformly at the 2 year follow-up, when
the effects of VNS are stabilized.
A. Okamura et al.
Epilepsy Research 167 (2020) 106463
Tomson, T., Wiebe, S., Zhang, Y.H., Zuberi, S.M., 2017. ILAE classification of the
epilepsies: Position paper of the ILAE Commission for Classification and
Terminology. Epilepsia 58, 512–521.
Shirozu, H., Hashizume, A., Masuda, H., Kakita, A., Otsubo, H., Kameyama, S., 2019.
Surgical strategy for focal cortical dysplasia based on the analysis of the spike onset
and peak zones on magnetoencephalography. J Neurosurg 4, 1–13.
Spencer, S.S., Spencer, D.D., Williamson, P.D., Mattson, R.H., 1985. Effects of corpus
callosum section on secondary bilaterally synchronous interictal EEG discharges.
Neurology 35, 1689–1694.
Steriade, M., McCormick, D.A., Sejnowski, T.J., 1993. Thalamocortical oscillations in the
sleeping and aroused brain. Science 262, 679–685.
Tanriverdi, T., Olivier, A., Poulin, N., Andermann, F., Dubeau, F., 2009. Long-term
seizure outcome after corpus callosotomy: a retrospective analysis of 95 patients.
J Neurosurg 110, 332–342.
Taulu, S., Hari, R., 2009. Removal of magnetoencephalographic artifacts with temporal
signal-space separation: demonstration with single-trial auditory-evoked responses.
Hum Brain Mapp 30, 1524–1534.
Vonck, K., Thadani, V., Gilbert, K., Dedeurwaerdere, S., De Groote, L., De Herdt, V.,
Goossens, L., Gossiaux, F., Achten, E., Thiery, E., Vingerhoets, G., Van Roost, D.,
Caemaert, J., De Reuck, J., Roberts, D., Williamson, P., Boon, P., 2004. Vagus nerve
stimulation for refractory epilepsy: a transatlantic experience. J Clin Neurophysiol
21, 283–289.
Vonck, K., De Herdt, V., Bosman, T., Dedeurwaerdere, S., Van Laere, K., Boon, P., 2008.
Thalamic and limbic involvement in the mechanism of action of vagus nerve
stimulation, a SPECT study. Seizure. 17, 699–706.
Wada, J.A., 2005. Callosal bisection and transcallosal secondary antiepileptogenesis.
Epilepsia 46 (Suppl 1), 2–6.
Donner, E.J., Weiss, S.K., Snead 3rd, O.C., Ochi, A., 2015. Rapid eye movement sleep
reveals epileptogenic spikes for resective surgery in children with generalized
interictal discharges. Epilepsia 56, 1445–1453.
Otsubo, H., Iida, K., Oishi, M., Okuda, C., Ochi, A., Pang, E., Weiss, S.K., Rutka, J.T.,
Chuang, S.H., Snead 3rd, O.C., 2005. Neurophysiologic findings of neuronal
migration disorders: intrinsic epileptogenicity of focal cortical dysplasia on
electroencephalography, electrocorticography, and magnetoencephalography.
J ChildNeurol 20, 357–363.
Palmini, A., Gambardella, A., Andermann, F., Dubeau, F., da Costa, J.C., Olivier, A.,
Tampieri, D., Gloor, P., Quesney, F., Andermann, E., et al., 1995. Intrinsic
epileptogenicity of human dysplastic cortex as suggested by corticography and
surgical results. AnnNeurol 37, 476–487.
Reid, S.A., 1990. Surgical technique for implantation of the neurocybernetic prosthesis.
Epilepsia 31 (Suppl 2), S38–9.
Rossi, G.F., Colicchio, G., Marchese, E., Pompucci, A., 1996. Callosotomy for severe
epilepsies with generalized seizures: outcome and prognostic factors. ActaNeurochir
(Wien) 138, 221–227.
Ruffoli, R., Giorgi, F.S., Pizzanelli, C., Murri, L., Paparelli, A., Fornai, F., 2011. The
chemical neuroanatomy of vagus nerve stimulation. J Chem Neuroanat 42, 288–296.
Sakuraba, R., Iwasaki, M., Okumura, E., Jin, K., Kakisaka, Y., Kato, K., Tominaga, T.,
Nakasato, N., 2016. High frequency oscillations are less frequent but more specific to
epileptogenicity during rapid eye movement sleep. Clin Neurophysiol 127, 179–186.
Sammaritano, M., Gigli, G.L., Gotman, J., 1991. Interictal spiking during wakefulness
and sleep and the localization of foci in temporal lobe epilepsy. Neurology 41,
290–297.
Scheffer, I.E., Berkovic, S., Capovilla, G., Connolly, M.B., French, J., Guilhoto, L.,
Hirsch, E., Jain, S., Mathern, G.W., Mosh´
e, S.L., Nordli, D.R., Perucca, E.,
...