14．
Masopust D, Vezys V, Marzo AL, Lefrancois L:
Preferential localization of effector memory cells in
１．
Spolski R, Leonard WJ: Interleukin-21: a double-edged
sword with therapeutic potential. Nat Rev Drug Discov
2014; 13: 379-395
nonlymphoid tissue. Science 2001; 291: 2413-2417
15．
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes
CM, CoyneJohnson L, et al.: Profound early control of
２． Parrish-Novak J, Dillon SR, Nelson A, Hammond
highly pathogenic SIV by an effector memory T-cell
A, Sprecher C, Gross JA, et al.: Interleukin 21 and
its receptor are involved in NK cell expansion and
regulation of lymphocyte function. Nature 2000; 408: 57-
vaccine. Nature 2011; 473: 523-527
16．
Hansen SG, Piatak MJr, Ventura AB, Hughes CM,
Gilbride RM, Ford JC, et al.: Immune clearance of
63
highly pathogenic SIV infection. Nature 2013; 502: 100-
３．
Spolski R, Leonard WJ: Interleukin-21: basic biology
and implications for cancer and autoimmunity. Annu
Rev Immunol 2008; 26: 57-79
104
17．
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L,
Siess DC, Drummond DD, et al.: Effector memory T
４．
Zeng R, Spolski R, Finkelstein SR, Oh S, Kovanen
cell responses are associated with protection of rhesus
PE, Hinrichs CS, et al.: Synergy of IL-21 and IL-15 in
monkeys from mucosal simian immunodeficiency virus
regulating CD8 T cell expansion and function. J Exp
Med 2005; 201: 139-148
５． Hinrichs CS, Spolski R, Paulos CM, Gattinoni L,
challenge. Nat Med 2009; 15: 293-299
18． Reyes-Sandoval A, Wyllie DH, Bauza K, Milicic A,
Forbes EK, Rollier CS, et al.: CD8+ T effector memory
Kerstann KW, Palmer DC, et al.: IL-2 and IL-21 confer
cells protect against liver-stage malaria. J Immunol
opposing differentiation programs to CD8+ T cells for
adoptive immunotherapy. Blood 2008; 111: 5326-5333
６．
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM: An
2011; 187: 1347-1357
19．
Ariotti S, Hogenbirk MA, Dijkgraaf FE, Visser LL,
Hoekstra ME, Song JY, et al.: T cell memory: skin-
interleukin- 21-interleukin-10-STAT3 pathway is critical
resident memory CD8+ T cells trigger a state of tissue-
for functional maturation of memory CD8 T cells.
Immunity 2011; 35: 792-805
７．
Elsaesser H, Sauer K, Brooks DG: IL-21 is required to
wide pathogen alert. Science 2014; 346: 101-105
20．
Gebhardt T, Wakim LM, Eidsmo L, Reading
PC, Heath WR, Carbone FR: Memory T cells in
control chronic viral infection. Science 2009; 324: 1569-
nonlymphoid tissue that provide enhanced local
1572
immunity during infection with herpes simplex virus.
８．
Fröhlich A, Kisielow J, Schmitz I, Freigang S,
Shamshiev AT, Weber J, et al.: IL-21R on T cells
is critical for sustained functionality and control of
Nat Immunol 2009; 10: 524-530
21．
Iijima N, Iwasaki A: T cell memory: a local
macrophage chemokine network sustains protective
chronic viral infection. Science 2009; 324: 1576-1580
tissue-resident memory CD4 T cells. Science 2014; 346:
９．
Yi JS, Du M, Zajac AJ: A vital role for interleukin-21
in the control of a chronic viral infection. Science 2009;
324: 1572-1576
93-98
22．
Sheridan BS, Pham QM, Lee YT, Cauley LS,
Puddington L, Lefrancois L: Oral infection drives a
10． Kaech SM, Cui W: Transcriptional control of effector
distinct population of intestinal resident memory CD8+
and memory CD8 T cell differentiation. Nat Rev
T cells with enhanced protective function. Immunity
Immunol 2012; 12: 749-761
11． Mueller SN, Gebhardt T, Carbone FR, Heath WR:
Memory T cell subsets, migration patterns, and tissue
2014; 40: 747-757
23．
Rahman M, Nara H, Onoda T, Araki A, Li J, Hoshino
T, et al.: Cloning and characterization of an isoform of
residence. Annu Rev Immunol 2013; 31: 137-161
12． Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia
A: Two subsets of memory T lymphocytes with
interleukin-21. FEBS Lett 2007; 581: 4001-4009
24．
Nara H, Rahman M, Araki A, Jin L, Takeda Y, Asao
H: IL-21 isoform is a membrane-bound ligand and
distinct homing potentials and effector functions.
activates directly interacted cells. Cytokine 2013; 61:
Nature 1999; 401: 708-712
13． Wherry EJ, Teichgräber V, Becker TC, Masopust D,
Kaech SM, Antia R, et al.: von Andrian U.H., Ahmed
656-663
25．
Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana
R. Lineage relationship and protective immunity of
－50－
FM, et al.: Role of interleukin-21 isoform in dextran
IL-21 reduces L. monocytogenes infection
sulfate sodium (DSS)- induced colitis, Cytokine 2013; 62:
induction of KLRG1+ effector CD8 T cells during acute
262-271
intracellular infection. J Immunol 2016; 196: 375-384
26． Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay
30． Yi JS, Ingram JT, Zajac AJ: IL-21 deficiency
CR, King C: A fundamental role for interleukin-21 in
influences CD8 T cell quality and recall responses
the generation of T follicular helper cells. Immunity
following an acute viral infection. J Immunol 2010; 185:
2008; 29: 127-137
4835-4845
27．
Nurieva R, Yang XO, Martinez G, Zhang Y,
31． Barker BR, Gladstone MN, Gillard GO, Panas MW,
Panopoulos AD, Ma L, et al.: Essential autocrine
Letvin NL: Critical role for IL-21 in both primary
regulation by IL-21 in the generation of inflammatory
and memory anti-viral CD8+ T-cell responses. Eur J
T cells. Nature 2007; 448: 480-483
Immunol 2010; 40: 3085-3096
28． Wollert T, Pasche B, Rochon M, Deppenmeier S, van
32． Novy P, Huang X, Leonard WJ, Yang Y: Intrinsic
den Heuvel J, Gruber AD, et al.: Extending the host
IL-21 signaling is critical for CD8 T cell survival
range of Listeria monocytogenes by rational protein
and memory formation in response to vaccinia viral
design. Cell 2007; 129: 891-902
infection. J Immunol 2011; 186: 2729-2738
29．
Moretto MM, Khan IA: IL-21 is important for
－51－
...
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