小型霊長類マーモセットの特性

1) 岩本光雄：サルの分類名（その 6：マーモセット科）

，霊長類研究．4：134-144，1998．

2) Davis NC : The susceptibility of marmosets to yellow fever virus. J Exp Med. 52 : 405-416, 1930.

3) Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Tomioka I, Sotomaru Y, Hirakawa R, Eto

T, Shiozawa S, Maeda T, Ito M, Ito R, Kito C,Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S,

Okano H and Nomura T : Generation of transgenic nonhuman primates with germline transmission. Nature.

459 : 523-527, 2009.

4) 伊藤豊志雄：コモンマーモセットの歴史と展望，実験医学．28：3029-3032，2010．

114

5)

6)

7)

8)

9)

10)

11)

12)

13)

14)

15)

Abbott DH, Barnett DK, Colman RJ, Yamamoto ME and Schultz-Darken NJ : Aspects of common marmoset

basic biology and life history important for biomedical research. Comparative Medicine. 53 : 339-350, 2003.

Yoshimoto T, Takahashi E, Yamashita S, Ohara K and Niimi K : Larger cages with housing unit environment

enrichment improve the welfare of marmosets. Exp Anim. 67 : 31-39, 2018.

Poswillo DE, Hamilton WJ and Sopher D : The marmoset as an animal model for teratological research.

Nature. 239 : 460-462, 1972.

木村雅昭，三谷博信，磯村八洲男：アンジオテンシン II 受容体拮抗薬，バルサルタン（ディオバン）の薬理

学的特性および臨床効果，日薬理誌．120：353-360，2002.

Jenner P, Rupniak NM, Rose S, Kelly E, Kilpatrick G, Lees A and Marsden CD :

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset. Neurosci

Lett. 50 : 85-90, 1984.

Ando K, Maeda J, Inaji M, Okauchi T, Obayashi S, Higuchi M, Suhara T and Tanioka Y : Neurobehavioral

protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets.

Psychopharmacology (Berl). 195 : 509-516, 2008.

Yang X, Chen Z, Wang Z, He G, Li Z, Shi Y, Gong N, Zhao B, Kuang Y, Takahashi E and Li W : A natural

marmoset model of genetic generalized epilepsy. Mol Brain. 15 : 16, 2022.

Yang X, Mao Y, Wang X, Ma D, Xu Z, Gong N, Henning B, Zhang X, He G, Shi Y, Eichler EE, Li Z, Takahashi E

and Li W : Population genetics of marmosets in Asian primate research centers and loci associated with

epileptic risk revealed by whole-genome sequencing. Zool Res. 44 : 837-847, 2023.

Iwanami A, Kaneko S, Nakamura M, Kanemura Y, Mori H, Kobayashi S, Yamasaki M, Momoshima S, Ishii H,

Ando K, Tanioka Y, Tamaoki N, Nomura T, Toyama Y and Okano H : Transplantation of human neural stem

cells for spinal cord injury in primates. J Neurosci Res. 80 : 182-190, 2005.

Kobayashi Y, Okada Y, Itakura G, Iwai H, Nishimura S, Yasuda A, Nori S, Hikishima K, Konomi T, Fujiyoshi K,

Tsuji O, Toyama Y, Yamanaka S, Nakamura M and Okano H : Pre-evaluated safe human iPSC-derived neural

stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity.

PLoS One. 7 : e52787, 2012.

Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara

J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ,

Yamamoto T, Sakakibara Y, Habu S, Hata JI, Okano H and Sasaki E : Generation of a Non-human primate

model of severe combined immunodeficiency using highly efficient genome editing. Cell Stem Cell. 19 :

127-138, 2016.

（特に重要な文献については，番号をゴシック体で表記している．

著者プロフィール

髙橋 英機（たかはし えいき）

九州大学教授（大学院医学研究院実験動物学）博士（医学）

◆略歴 1970 年神奈川県に生まれる．1994 年北海道大学獣医学部獣医学科卒業．2000 年筑波大学

連携大学院医学系研究科博士課程修了．1994 年〜2006 年エーザイ株式会社筑波研究所．

2001 年 〜2003 年 米 国 University of California, Los Angeles (UCLA), Brain Research

Institute．2006 年〜2019 年理化学研究所脳科学総合研究センター．2012 年〜2021 年中国

上海交通大学 Bio-X 研究院客座教授．2021 年九州大学大学院医学研究院実験動物学准教

授．2023 年 5 月より現職．

◆研究テーマと抱負 モデル動物を用いた高次脳機能疾患に寄与する遺伝的・環境的要因の解明に

取組むとともに，実験動物医学を基盤にした動物実験の適正な実施を推進します．

◆趣味 旅行

小型霊長類マーモセットの特性

115

Characteristics of Common Marmoset

Eiki TAKAHASHI

Department of Biomedicine, Graduate School of Medical Sciences, Kyushu University

Abstract

Rodent laboratory animals, such as mice and rats, have greatly contributed to biomedical research.

While their usefulness will remain unchanged in the future, nonhuman primates also provide excellent

models for research to examine disease mechanisms and to assess the safety and efficacy of developing

novel therapeutic approaches because of their genetic, metabolic, and physiological similarities to

humans. Among nonhuman primates, the common marmoset (Callithrix jacchus) is a suitable

laboratory animal. The common marmoset has several advantages compared to macaque species,

including a smaller body size, availability, easy breeding in captivity, low husbandry costs, fewer

zoonotic issues, early sexual maturation, and a short gestation period, indicating that the common

marmoset may represent an alternative species to traditional nonhuman primates such as Cynomolgus

macaque, Rhesus macaque, and Japanese macaque. In addition, the development of transgenic

marmosets has become possible. This article provides an overview of the ecology, husbandry, and

characteristics of the common marmoset.

Key words : Common marmoset, Model animal, Nonhuman primate

...